Acute toxicity study and antipyretic effect of the brown alga t&lt;i&gt;Turbinaria conoides&lt;/i&gt; (J. agardh) kuetz.

Kumar, Sandeep; Kumar, Yogesh; Khan, M. S. Y.; Anbu, J.; Sam, Kishore Gnana

doi:10.4314/ajtcam.v6i3.57159

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…The acute toxicity study was determined in mice as LD50 > 10 g kg -1 , which agrees with other toxicity studies of brown algae such as Sargassum liebmannii and the fucoidan from Saccharina japonica (Kumar et al 2009, Tapia-Martinez et al 2019. According to the value of LD50 in the scale proposed by Loomis & Hayes (1996), M. pyrifera can be classified as non-toxic.…”

Section: Discussionsupporting

confidence: 83%

Toxicological and therapeutic evaluation of the algae <i>Macrocystis pyrifera</i> (Phaeophyceae) in rodents

Tapia-Martínez¹,

Cano-Europa²,

Casas-Valdéz³

et al. 2020

RBMO

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Macrocystis pyrifera is a giant brown seaweed with high nutritional content, used as a dietary supplement in some farm animals. It contains fucoidan which has a pharmacological effect on lipids and glucose metabolism. Some brown seaweeds can bioaccumulate toxic elements in their cell wall, representing a problem if toxicity tests that guarantee the safety of their consumption are not done. M. pyrifera, does not present toxicological studies that guarantee its safety. This work aimed to perform the acute and subchronic toxicological evaluation of M. pyrifera in rodents as well as to determine its possible therapeutic effect. Fronds of M. pyrifera were collected in Baja California Sur, Mexico, for drying and obtaining algae flour. The acute toxicity test LD50 was performed in C57BL / 6 male mice (25 ± 3 g) for 7 days, finding an LD50 greater than 10 g kg-1. Subchronic toxicity was determined for 121 days in adult male Sprague Dawley rats (98 ± 2 g), during which the experimental animals showed no signs of toxicity, or changes in the hematological, biochemical and histopathological parameters of the organs. The reactive oxygen species, lipid peroxidation or glutathione ratio were not different from the control group. A therapeutic effect on the regulation of body weight and a hypolipidemic effect (triacylglycerides: 82.27 ± 5.55 mg dl-1, cholesterol: 98.61 ± 6.48 mg dl-1) were found. It is concluded that, under the conditions in which this study was developed, the consumption of M. pyrifera as a functional ingredient is safe.

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Section: Discussionsupporting

confidence: 83%

Toxicological and therapeutic evaluation of the algae <i>Macrocystis pyrifera</i> (Phaeophyceae) in rodents

Tapia-Martínez¹,

Cano-Europa²,

Casas-Valdéz³

et al. 2020

RBMO

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“…In addition, no behavioral changes, consciousness defects, or comas were seen in the tested animals, thus, indicating that the lethal dose 50 (LD 50 ) of D. dichotoma is significantly high in vivo (well above 5000 mg/kg body weight). Along the same line, the acute toxicity of the brown algae Turbinaria conoides reported that oral ingestion of a dose up to 5 g/kg of methanol and ethanol-water (1 : 1) extracts was highly nontoxic and did not cause single mortality in rats [58].…”

Section: Acute Toxicitymentioning

confidence: 89%

The Yemeni Brown AlgaeDictyota dichotomaExhibit HighIn VitroAnticancer Activity Independent of Its Antioxidant Capability

El-Shaibany

Al‐Habori

Al-Maqtari

et al. 2020

BioMed Research International

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e aim of this study was to investigate the anticancer and antioxidant activities as well as the safety of the brown algae Dictyota dichotoma of the Western seacoast of Yemen. Cytotoxicity of methanol extract of D. dichotoma and several of its fractions, petroleum ether, chloroform, ethyl acetate, n-butanol, and aqueous extracts against seven different cancer cell lines was determined by crystal violet staining. e antioxidant activity was also assessed using the DPPH radical scavenging assay. Acute toxicity study was performed on rats at increasing doses of the methanol extract. Extracts of D. dichotoma exerted a significant dose-dependent cytotoxicity on the seven tumor cell lines but were generally more selective on MCF-7 and PC-3. Among all fractions, the chloroform fraction of the D. dichotoma displayed the highest cytotoxic activity and was most effective in MCF-7, PC3, and CACO cells (IC 50 � 1.93 ± 0.25, 2.2 ± 0.18, and 2.71 ± 0.53 μg/mL, respectively). e petroleum ether fraction was also effective, particularly against MCF-7 and PC-3 (IC 50 � 4.77 ± 0.51 and 3.93 ± 0.51 μg/mL, respectively) whereas the activity of the ethyl acetate fraction was more pronounced against HepG2 and CACO (IC 50 � 5.06 ± 0.21 and 5.06 ± 0.23 μg/mL, respectively). Of all the extracts tested, the crude methanolic extract of the algae exhibited only a modest antioxidant potential (IC 50 � 204.6 ± 8.3 μg/mL). Doses as high as 5000 mg/kg body weight of D. dichotoma methanolic extracts were safe and well tolerated by rats. e overall results showed that D. dichotoma exhibited a significant cytotoxic activity probably due to the occurrence of nonpolar cytotoxic compounds, which is independent of its antioxidant capability.

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“…Brown alga, Turbinaria conoides have evaluated with n-hexane, cyclohexane, methanol and ethanol-water for acute antipyretic activity study reveals that n-hexane, cyclohexane and ethanol-water extracts caused increase in serum cholesterol, protein and alkaline phosphatase levels and concluded that Cyclohexane extract exhibited more significant antipyretic activity than the other extracts [12].…”

Section: S Sadish Kumar Et Al (2009)mentioning

confidence: 99%

“…It is used as antipyretic [12], Antimicrobial [13], Antidiabetic [15], Antioxidant [17], Hepatoprotective [23], Antifungal [25], antiulcer [27], Antitumor [28], Anticoagulant [37], Antibacterial [40].…”

Section: Usesmentioning

confidence: 99%

Pharmacological aspects of Turbinaria

Alka¹,

Tyagi²,

Kumar³

2017

IJRDPL

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Seaweeds, are plant-like organisms that generally live attached to rock or other hard substrata in coastal areas. The brown color of these algae results from the dominance of the xanthophyll pigment fucoxanthin. Brown algae (Phaeophyceae) is a genus of Turbinaria found in tropical marine waters, which grows on rocky substrates. Turbinaria species are consumed by herbivorous fishes and echinoids in tropical areas, it has a low level of phenolics and tannins. It is widely distributed in tropical and subtropical areas of central, western Pacific and Indian Ocean. Turbinaria belongs to the class-Anthozoa, Order-Scleractinia, family-Dendrophylliidae, GenusTurbinaria. Different extracts of the Turbinaria shows the presence of phytoconstituents like alkaloids,

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Acute toxicity study and antipyretic effect of the brown alga t<i>Turbinaria conoides</i> (J. agardh) kuetz.

Cited by 9 publications

References 14 publications

Toxicological and therapeutic evaluation of the algae <i>Macrocystis pyrifera</i> (Phaeophyceae) in rodents

Toxicological and therapeutic evaluation of the algae <i>Macrocystis pyrifera</i> (Phaeophyceae) in rodents

The Yemeni Brown AlgaeDictyota dichotomaExhibit HighIn VitroAnticancer Activity Independent of Its Antioxidant Capability

Pharmacological aspects of Turbinaria

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