Acute tobacco smoke exposure alters the profile of metabolites produced from benzo[a]pyrene by the isolated perfused rabbit lung

The effects of a cocarcinogen, ferric oxide, on the metabolism of benzo[a]pyrene in the isolated perfused lung

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The effects of a cocarcinogen, ferric oxide, on the metabolism of benzo[a]pyrene in the isolated perfused lung

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On cancer risk estimation of urban air pollution.

“…Apart from a carcinogenic action of the particles per se (see below), adsorption onto particles has been shown to increase the retention time in lung tissue of PAH such as B[a]P, partly by decreasing the rate of metabolism (35). This depot effect may lead to increased induction of PAH-metabolizing enzymes, as shown with respect to the formation of B[a]P 7,8-and 9,10-dihydrodiols in experiments with perfused lung (35,36) and raised levels of DNA-adducts of B[a]P metabolites, particularly the mutagenic 7,8-diol-9, 1 0-epoxide, provided the desorption is not too slow (37). These enzyme inductions result in raised doses of genotoxic factors and may be seen as cocarcinogenic effects of an interaction with the Ah receptor.…”

The effects of a cocarcinogen, ferric oxide, on the metabolism of benzo[a]pyrene in the isolated perfused lung

“……”

On cancer risk estimation of urban air pollution.

“…Apart from a carcinogenic action of the particles per se (see below), adsorption onto particles has been shown to increase the retention time in lung tissue of PAH such as B[a]P, partly by decreasing the rate of metabolism (35). This depot effect may lead to increased induction of PAH-metabolizing enzymes, as shown with respect to the formation of B[a]P 7,8-and 9,10-dihydrodiols in experiments with perfused lung (35,36) and raised levels of DNA-adducts of B[a]P metabolites, particularly the mutagenic 7,8-diol-9, 1 0-epoxide, provided the desorption is not too slow (37). These enzyme inductions result in raised doses of genotoxic factors and may be seen as cocarcinogenic effects of an interaction with the Ah receptor.…”

The effects of a cocarcinogen, ferric oxide, on the metabolism of benzo[a]pyrene in the isolated perfused lung

“……”

On cancer risk estimation of urban air pollution.

“…Apart from a carcinogenic action of the particles per se (see below), adsorption onto particles has been shown to increase the retention time in lung tissue of PAH such as B[a]P, partly by decreasing the rate of metabolism (35). This depot effect may lead to increased induction of PAH-metabolizing enzymes, as shown with respect to the formation of B[a]P 7,8-and 9,10-dihydrodiols in experiments with perfused lung (35,36) and raised levels of DNA-adducts of B[a]P metabolites, particularly the mutagenic 7,8-diol-9, 1 0-epoxide, provided the desorption is not too slow (37). These enzyme inductions result in raised doses of genotoxic factors and may be seen as cocarcinogenic effects of an interaction with the Ah receptor.…”