Acute stress alters transcript expression pattern and reduces processing of proBDNF to mature BDNF in Dicentrarchus labrax

Tognoli, Chiara; Rossi, Federica; Cola, Francesco Di; Baj, Gabriele; Tongiorgi, Enrico; Terova, Genciana; Saroglia, Marco; Bernardini, Giovanni; Gornati, Rosalba

doi:10.1186/1471-2202-11-4

Cited by 47 publications

(37 citation statements)

References 62 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, all transcripts are translated into an identical BDNF protein [15,16,17,18]. Exons I, II, IV and VI of BDNF between humans and rodents are highly conserved [19]. Each exon is regulated by its own unique promoter, conferring temporal and spatial control of Bdnf expression in an activity-dependent manner.…”

Section: Bdnf Genementioning

confidence: 99%

Epigenetic Regulation of BDNF Gene during Development and Diseases

Chen

2017

IJMS

View full text Add to dashboard Cite

Brain-derived neurotrophic factor (BDNF) is required for the development of the nervous system, proper cognitive function and memory formation. While aberrant expression of BDNF has been implicated in neurological disorders, the transcriptional regulation of BDNF remains to be elucidated. In response to different stimuli, BDNF expression can be initiated from different promoters. Several studies have suggested that the expression of BDNF is regulated by promoter methylation. An emerging theme points to the possibility that histone modifications at the BDNF promoters may link to the neurological pathology. Thus, understanding the epigenetic regulation at the BDNF promoters will shed light on future therapies for neurological disorders. The present review summarizes the current knowledge of histone modifications of the BDNF gene in neuronal diseases, as well as the developmental regulation of the BDNF gene based on data from the Encyclopedia of DNA Elements (ENCODE).

show abstract

Section: Bdnf Genementioning

confidence: 99%

Epigenetic Regulation of BDNF Gene during Development and Diseases

Chen

2017

IJMS

View full text Add to dashboard Cite

show abstract

“…The expression of BDNF transcripts is tissue-specific, that is, it is differentially expressed throughout different brain sites and peripheral tissues (29,247). Moreover, environmental cues, such as stress, can alter transcript expression (80,167,248), which is associated with alterations in pro-BDNF/total BDNF ratio (248). The exact role of each of these individual transcripts is still largely unknown.…”

mentioning

confidence: 99%

The lighter side of BDNF

Noble

Billington

Kotz³

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

234

168

View full text Add to dashboard Cite

Brain-derived neurotrophic factor (BDNF) mediates energy metabolism and feeding behavior. As a neurotrophin, BDNF promotes neuronal differentiation, survival during early development, adult neurogenesis, and neural plasticity; thus, there is the potential that BDNF could modify circuits important to eating behavior and energy expenditure. The possibility that "faulty" circuits could be remodeled by BDNF is an exciting concept for new therapies for obesity and eating disorders. In the hypothalamus, BDNF and its receptor, tropomyosin-related kinase B (TrkB), are extensively expressed in areas associated with feeding and metabolism. Hypothalamic BDNF and TrkB appear to inhibit food intake and increase energy expenditure, leading to negative energy balance. In the hippocampus, the involvement of BDNF in neural plasticity and neurogenesis is important to learning and memory, but less is known about how BDNF participates in energy homeostasis. We review current research about BDNF in specific brain locations related to energy balance, environmental, and behavioral influences on BDNF expression and the possibility that BDNF may influence energy homeostasis via its role in neurogenesis and neural plasticity. food intake; body weight; ventromedial hypothalamus; paraventricular nucleus; brain-derived neurotrophic factor BRAIN-DERIVED NEUROTROPHIC factor (BDNF) is a member of the neurotrophin family of growth factors (151), along with nerve growth factor (152), and neurotrophin (NT) 3 (67, 163), NT 4/5 (28), and NT 6 (88). Neurotrophins are synthesized as 32-35-kDa pro-isoforms, which are later cleaved to mature forms that dimerize after translation and then act as receptor ligands (136). Whereas the precursor forms of other neurotrophins are constitutively secreted, the 32-kDa pro-BDNF is packaged into vesicles of a regulated pathway and is secreted in an activitydependent manner (87). Pro-BDNF may be secreted as is (48), cleaved by the extracellular protease plasmin (202), or interact with the pan-neurotrophin receptor p75 NTR and other receptors that cause an independent biological effect (244). Alternatively, pro-BDNF is processed to the mature form intracellularly by furin or proconvertases, where it forms C-terminal dimers (212, 226).Mature BDNF is considered the biologically active form, which has a high affinity for the tropomyosin-related kinase B (TrkB) receptor (130). Both BDNF and TrkB are present in presynaptic axon terminals and postsynaptic dendritic compartments of neurons, and they are capable of bidirectional release and activity [for review, see Tyler et al. (259)]. Typical of the neurotrophic factors, BDNF stimulates the development and differentiation of new neurons (3, 131) and promotes long-term potentiation (LTP) (139,140,205), and neuron survival (97,105,116). BDNF is abundantly expressed throughout the developing and mature CNS and in many peripheral tissues, including muscle, liver, and adipose (42,159,182,261). Regional differences between BDNF mRNA levels and protein concentrations in the CNS a...

show abstract

“…BDNF is differentially expressed in diverse tissues and, within the brain, in various regions (Bishop et al 1994; Timmusk et al 1993). Moreover, transcript expression can be altered by environmental factors, such as stress (Fuchikami et al 2009; Marmigere et al 2003), so that the ratio of pro/mature BDNF may change (Tognoli et al 2010). In addition to multiple isoforms, the gene has numerous polymorphisms.…”

mentioning

confidence: 99%

BDNF Val66Met and cognition: all, none, or some? A meta‐analysis of the genetic association

Mandelman

Grigorenko

2011

Genes Brain and Behavior

119

View full text Add to dashboard Cite

The Val66Met, G196A (rs6265) polymorphism in the brain-derived neurotrophic factor gene, BDNF, located at 11p13, has been associated with a wide range of cognitive functions. Yet, the pattern of results is complex and conflicting. In the current study we conducted a meta-analysis that included 23 publications containing 31 independent samples comprised of 7,095 individuals. The phenotypes that were examined in this analysis covered a wide variety of cognitive functions and included indicators of general cognitive ability, memory, executive function, visual processing skills, and cognitive fluency. The meta-analysis did not establish significant genetic associations between the Val66Met polymorphism and any of the phenotypes that were included.

show abstract

Acute stress alters transcript expression pattern and reduces processing of proBDNF to mature BDNF in Dicentrarchus labrax

Cited by 47 publications

References 62 publications

Epigenetic Regulation of BDNF Gene during Development and Diseases

Epigenetic Regulation of BDNF Gene during Development and Diseases

The lighter side of BDNF

BDNF Val66Met and cognition: all, none, or some? A meta‐analysis of the genetic association

Contact Info

Product

Resources

About