2002
DOI: 10.1002/jbt.10022
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Abstract: Modulation of the cytochrome P450 (CYP) monooxygenase system (P450) by arsenite was investigated in male, adult Sprague-Dawley rats treated with a single dose (75 micromol/kg, sc) of sodium arsenite (As3+). Total CYP content and P450-dependent 7-pentoxyresorufin O-pentylation (PROD) and 7-ethoxyresorufin O-deethylation (EROD) activities of liver microsomes decreased maximally (33, 35, and 50% of control, respectively) 1 day after As3+ treatment. Maximum decreases of CYP content and P450 catalytic activities co… Show more

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Cited by 13 publications
(15 citation statements)
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“…Our laboratory previously reported increased pulmonary CYP1A1-dependent EROD activity after acute As 3+ treatment in the rat [10,34]. These findings demonstrated for the first time a selective in vivo increase of the catalytic activity of a CYP1A isozyme after As 3+ treatment.…”
Section: Discussionmentioning
confidence: 56%
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“…Our laboratory previously reported increased pulmonary CYP1A1-dependent EROD activity after acute As 3+ treatment in the rat [10,34]. These findings demonstrated for the first time a selective in vivo increase of the catalytic activity of a CYP1A isozyme after As 3+ treatment.…”
Section: Discussionmentioning
confidence: 56%
“…Therefore, the increase in Cyp2a5 monooxygenase activity may reflect modulation of protein degradation and mRNA stabilization by As 3+ resulting in accumulation of Cyp2a5. The significant differences observed in CYP modulation (CYP1A1 vs Cyp2a5), following acute As 3+ administration, between the rat [34] and mouse, may be attributed to the toxicokinetics of this metalloid. The liver and kidney are two of the most prominent sites of As 3+ -mediated toxicity in the body.…”
Section: Discussionmentioning
confidence: 84%
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“…Due to high expression of CYP1A1 and CYP3A1 in rat intestine (Zhang et al, 1996;Turan et al, 2001;Kaminsky and Zhang, 2003), we can conclude that the aforementioned enzymes are involved in the metabolic biotransformation of AM to DEA in intestine. It is of note that in addition to intestine, CYP1A1 is also an important enzyme found in lung (Seubert et al, 2002;Zhao et al, 2004). Furthermore, high expression of CYP1A1, CYP1A2, CYP2B1, CYP3A1, and CYP3A2 has been shown to occur constitutively within small hepatocytes of adult rats.…”
Section: Discussionmentioning
confidence: 99%
“…The induction of HO-1 by As 3+ will result in the formation of biliverdin and subsequently bilirubin, which have been shown to act as AhR ligands [12,25,26,89]. However, although the increase in pulmonary CYP1A1 expression was associated with an increase in total plasma bilirubin concentrations, the administration of bilirubin, a possible endogenous ligand, to the lung through intra-tracheal injection did not increase CYP1A1 mRNA [111,112]. As 3+ -induced oxidative stress may result in the subsequent release of arachidonic acid from glycerolphospholipids, which has also been previously shown to regulate the AhR signaling pathway [12,27].…”
Section: As 3+mentioning
confidence: 94%