Acute Respiratory Distress Syndrome: Emerging Research in China

Song, Yuanlin; Xu, Feng; Seeley, E. Scott; Ou, Jiaxian; Zhu, Xiaodan; Sun, Rui-Juan; Bai, Chunxue

doi:10.1164/rccm.201407-1392ed

Cited by 7 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The difference between the two groups was tested using a two-tailed independent Student's t-tests for normally distributed variables and the Wilcoxon rank sum test for non-normally distributed data. The associations between the NLR and patient baseline characteristics for non-parametrically distributed variables were assessed using the χ 2 test, Fisher's exact method, or the Cochran-Mantel-Haenszel χ 2 test. Univariate and multivariate analyses were completed with Cox proportional hazards regression tests.…”

Section: Discussionmentioning

confidence: 99%

“…Knowledge on epidemiological surveys of ARDS in China has been limited. Epidemiological surveys in Beijing, Shanghai, Chongqing and other regional cities found that the mortality from ARDS among ICU patients in China is variable (22-100%) (2). Although recent advances in intensive care models have been processed (3)(4), mortality remains high (1).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neutrophil-to-lymphocyte ratio as a prognostic marker in acute respiratory distress syndrome patients: a retrospective study

Wang¹,

Ju²,

Chen³

et al. 2018

J. Thorac. Dis.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio as a prognostic marker in acute respiratory distress syndrome patients: a retrospective study

Wang¹,

Ju²,

Chen³

et al. 2018

J. Thorac. Dis.

Self Cite

View full text Add to dashboard Cite

show abstract

“…PA infection is highly prone to drug resistance, and the means of treatment are scarce, the mortality rate is extremely high despite improvements in supportive care and antibiotic use ( Neuhauser et al., 2003 ; Shorr, 2009 ; Von Baum et al., 2010 ; Song et al., 2012 ; Peng et al., 2014 ; Wang et al., 2014 ). If PA-infected patients have acute respiratory distress syndrome (ARDS), the mortality rate can reach up to 70% ( Song et al., 2014 ). To date, several studies have demonstrated that the administration of mesenchymal stem or stromal cell (MSC) attenuated lung inflammation and histological damage while improving recovery from acute lung injury (ALI) caused by endotoxin ( Gupta et al., 2007 ; Mei et al., 2007 ; Xu et al., 2007 ; Xu et al., 2008 ; Krasnodembskaya et al., 2010 ), E. coli ( Gupta et al., 2012 ; Lee et al., 2013 ) or sepsis ( Nemeth et al., 2009 ; Gonzalez-Rey et al., 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Adipose-Derived Mesenchymal Stem Cells Ameliorating Pseudomonas aeruginosa–induced Acute Lung Infection via Inhibition of NLRC4 Inflammasome

Zhu

Jia

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundPseudomonas aeruginosa (PA) is one of the most common Gram-negative bacteria causing hospital-acquired pulmonary infection, with high drug resistance and mortality. Therefore, it is urgent to introduce new non-antibiotic treatment strategies. Mesenchymal stem cells (MSCs), as important members of the stem cell family, were demonstrated to alleviate pathological damage in acute lung injury. However, the potential mechanism how MSC alleviate acute lung infection caused by PA remains unclear.ObjectiveThe purpose of this study was to investigate the effects of Adipose-derived mesenchymal stem cells (ASCs) on acute pulmonary infections and the possible mechanisms how ASCs reduce pulmonary inflammation induced by PA.MethodsThe therapeutic and mechanistic effects of ASCs on PA pulmonary infection were evaluated respectively in a murine model as well as in an in vitro model stimulated by PA and co-cultured with ASCs.Results1. ASCs treatment significantly reduced the bacterial load, inflammation of lung tissue and histopathological damage by PA. 2. PA infection mainly activated Nod-like receptor containing a caspase activating and recruitment domain 4 (NLRC4) inflammasome in the lung of mice. ASCs attenuated acute lung infection in mice by inhibiting NLRC4 inflammasome activation. 3. NLRC4−/− mice showed a significant improvement in survival rate and lung bacterial load after PA infection. 4. ASCs mainly increased expression and secretion of STC‐1 in response to PA‐stimulated NLRC4 inflammasome activation.ConclusionsPA infection attenuated macrophage phagocytosis through activation of NLRC4 inflammasome in macrophages, which eventually led to pulmonary inflammatory damage in mouse; ASCs reduced the activation of NLRC4 inflammasome in macrophages induced by PA infection, thereby increasing the phagocytic ability of macrophages, and ultimately improving lung tissue damage in mouse; ASCs may inhibit NLRC4 inflammasome through the secretion of STC-1.

show abstract

“…China makes substantial efforts to investigate the cellular and molecular mechanisms of ALI/ARDS during recent years . Chunxue Bai (Fudan University) identified both capillary and alveolar epithelium stress failure contributed to high altitude pulmonary edema, and keratinocyte growth factor‐2 (KGF‐2) pre‐administration significantly reduced lung injury and improved survival .…”

Section: Ali/ardsmentioning

confidence: 99%

NSFC spurs significant basic research progress of respiratory medicine in China

Sun

Wang

et al. 2015

Clinical Respiratory J

Self Cite

View full text Add to dashboard Cite

Over the years, research in respiratory medicine has progressed rapidly in China. This commentary narrates the role of the National Natural Science Foundation of China (NSFC) in supporting the basic research of respiratory medicine, summarizes the major progress of respiratory medicine in China, and addresses the main future research directions sponsored by the NSFC.Please cite this paper as: Sun R, Xu F, Wang C and Dong E. NSFC spurs significant basic research progress of respiratory medicine in China. Clin Respir J 2017; 11: 271-284.

show abstract

Acute Respiratory Distress Syndrome: Emerging Research in China

Cited by 7 publications

References 23 publications

Neutrophil-to-lymphocyte ratio as a prognostic marker in acute respiratory distress syndrome patients: a retrospective study

Neutrophil-to-lymphocyte ratio as a prognostic marker in acute respiratory distress syndrome patients: a retrospective study

Adipose-Derived Mesenchymal Stem Cells Ameliorating Pseudomonas aeruginosa–induced Acute Lung Infection via Inhibition of NLRC4 Inflammasome

NSFC spurs significant basic research progress of respiratory medicine in China

Contact Info

Product

Resources

About