Acute Renal Failure after Lung Transplantation: Incidence, Predictors and Impact on Perioperative Morbidity and Mortality

Rocha, Paulo Novis; Rocha, Ana Thereza; Palmer, Scott M.; Davis, Robert D.; Smith, Stephen R.

doi:10.1111/j.1600-6143.2005.00867.x

Cited by 123 publications

(124 citation statements)

References 53 publications

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“…A recent meta-analysis of these studies suggested that both ARDS and mechanical ventilation were associated with a 3-fold increase in the risk of AKI (46). Most of the studies included in this analysis were observational studies, however, and focused on specific populations such as trauma patients (27), lung transplant recipients (29), cancer patients (30), or patients with hepatic failure (32). Thus, the general applicability of their findings is unclear.…”

Section: Discussionmentioning

confidence: 98%

“…Despite this large body of evidence suggesting an interaction between respiratory failure and AKI, few studies have evaluated the effect of respiratory failure on renal function by clearly assessing the time of mechanical ventilation initiation relative to the onset of AKI (27)(28)(29)(30)(31)(32). A recent meta-analysis of these studies suggested that both ARDS and mechanical ventilation were associated with a 3-fold increase in the risk of AKI (46).…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have specifically addressed the association between respiratory failure and AKI (27)(28)(29)(30)(31)(32). In addition, most of these studies were performed in specific patient populations and failed to adequately address the effect of ARDS on renal function (27,(29)(30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, most of these studies were performed in specific patient populations and failed to adequately address the effect of ARDS on renal function (27,(29)(30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%

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Acute Respiratory Distress Syndrome and Risk of AKI among Critically Ill Patients

Darmon¹,

Clec’h²,

Adrie³

et al. 2014

Clinical Journal of the American Society of Nephrology

166

159

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Background and objectives Increasing experimental evidence suggests that acute respiratory distress syndrome (ARDS) may promote AKI. The primary objective of this study was to assess ARDS as a risk factor for AKI in critically ill patients.Design, setting, participants, & measurements This was an observational study on a prospective database fed by 18 intensive care units (ICUs). Patients with ICU stays .24 hours were enrolled over a 14-year period. ARDS was defined using the Berlin criteria and AKI was defined using the Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease criteria. Patients with AKI before ARDS onset were excluded.Results This study enrolled 8029 patients, including 1879 patients with ARDS. AKI occurred in 31.3% of patients and was more common in patients with ARDS (44.3% versus 27.4% in patients without ARDS; P,0.001). After adjustment for confounders, both mechanical ventilation without ARDS (odds ratio [OR], 4.34; 95% confidence interval [95% CI], 3.71 to 5.10) and ARDS (OR, 11.01; 95% CI, 6.83 to 17.73) were independently associated with AKI. Hospital mortality was 14.2% (n=1140) and was higher in patients with ARDS (27.9% versus 10.0% in patients without ARDS; P,0.001) and in patients with AKI (27.6% versus 8.1% in those without AKI; P,0.001). AKI was associated with higher mortality in patients with ARDS (42.3% versus 20.2%; P,0.001).Conclusions ARDS was independently associated with AKI. This study suggests that ARDS should be considered as a risk factor for AKI in critically ill patients.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In addition, most of these studies were performed in specific patient populations and failed to adequately address the effect of ARDS on renal function (27,(29)(30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acute Respiratory Distress Syndrome and Risk of AKI among Critically Ill Patients

Darmon¹,

Clec’h²,

Adrie³

et al. 2014

Clinical Journal of the American Society of Nephrology

166

159

View full text Add to dashboard Cite

show abstract

“…The importance of recognizing pretransplantation renal function deficits is underscored by the observation that CKD before transplantation portends poor posttransplant survival. 10,15,22,23 Perioperative Renal Insults AKI during the peritransplantation period creates additional risk for posttransplantation CKD (Figure 1). Mechanisms during and after surgery that may precipitate AKI include hypotension and hypoperfusion, administration of nephrotoxic agents such as radiocontrast, sepsis, and aggressive diuresis.…”

Section: Triggering Insultmentioning

confidence: 99%