Acute phase proteins in male Chinese schizophrenic patients in Singapore

Wong, Chloe; Wing-Foo, Tsoi; Saha, N.

doi:10.1016/s0920-9964(96)00037-0

Cited by 56 publications

(46 citation statements)

References 20 publications

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“…Moreover, the negative subgroup showed a significant reduction in the bilirubin level. A significant reduction in the bilirubin and albumin levels was in line with previous findings, which suggested a similar direction in the antioxidant level [1,[3][4][5]7], supporting the hypothesis of an alteration in the antioxidant levels in schizophrenia patients. It is notable that the negative subgroup had a significantly lower bilirubin level, as suggested in a previous study, which showed that an altered antioxidant capacity may be associated with the symptomatology and treatment implications in schizophrenia, particularly negative symptoms [2].…”

Section: Discussionsupporting

confidence: 90%

“…Most recently, Reddy et al [5] have found that patients with firstepisode schizophrenia (FSPR) had significantly lower albumin, uric acid and bilirubin levels than normal controls, suggesting an early involvement of the defective antioxidant system in the course of illness regardless of antipsychotic effects. Neuropsychobiology 2004;50:54-56 55 However, there are few data showing a relationship between antioxidant levels in drug-naïve FSPR and risperidone-treated chronic schizophrenia (RCSPR) patients, in particular lacking in the Asian population [7]. Furthermore, there might be a difference in the antioxidant system according to the ethnic background [8].…”

Section: Introductionmentioning

confidence: 99%

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Decreased Plasma Antioxidants in Schizophrenia

Pae¹,

Paik²,

Lee³

et al. 2004

Neuropsychobiology

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An aberration in the level of antioxidants has been suggested in schizophrenia. Therefore, this study examined the difference in the antioxidant level between patients with schizophrenia and healthy controls, as well as the difference between the drug-naïve schizophrenic patients with a first episode (FSPR) and the risperidone-treated chronic schizophrenia (RCSPR) patients. The plasma albumin, bilirubin and uric acid levels were determined in 47 FSPR and 55 chronic schizophrenia patients who met the DSM-IV criteria for schizophrenia, and in 68 controls. The albumin and bilirubin levels were significantly lower in the schizophrenic patients compared to the controls, although there was no significant difference between the FSPR and RCSPR patients. The bilirubin level was significantly lower in the negative subgroup of the patient group. This study supports the hypothesis that an aberration in the antioxidant levels may be involved in schizophrenia. In addition, this study suggests that the antioxidant level may be associated with the clinical symptomatology as well as the treatment implications in schizophrenia, particularly the negative symptoms.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Decreased Plasma Antioxidants in Schizophrenia

Pae¹,

Paik²,

Lee³

et al. 2004

Neuropsychobiology

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show abstract

“…It is important to mention that this metaanalysis controlled for potential confounding factors including age, gender and duration of illness. Other inflammation related proteins found to be increased in patients include complement system proteins such as complement C3 and C4 (Maes et al, 1997a;Wong et al, 1996).…”

Section: Immune Response and Inflammationmentioning

confidence: 99%

Applications of blood-based protein biomarker strategies in the study of psychiatric disorders

Chan

Gottschalk

Haenisch

et al. 2014

Progress in Neurobiology

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“…There are reports of C3 concentration decreases in chronic 70 and increases in drug-free patents. 71 However, the majority of the studies concluded nonsignificant or no alterations (Table II).…”

Section: Complement In Schizophreniamentioning

confidence: 99%