Acute pericarditis: A peculiar manifestation of common variable immune deficiency

Abstract

Common variable immune deficiency (CVID) is known as the most prevalent symptomatic inborn error of immunity associated with autoimmune and inflammatory complications in addition to recurrent infections. In this study, we investigated the prevalence of acute pericarditis as a complication in the past medical history of 337 CVID patients. We found five patients (1.5%) that had experienced acute pericarditis, and described the medical history of three patients.

Pyopericardium presenting as pericardial tamponade in a patient with common variable immunodeficiency disorder

“…Both cases are associated with non-compliance with Ig therapy, which can point to a protective role against pyopericardium. Unlike our patient, the outcome was poor, with death at the age of 13 from respiratory distress and pneumonia 7…”

“…Reviewing the literature, we only found seven cases of pericardial diseases in patients with CVID. One case of pericardial tamponade due to primary effusion lymphoma, one case of pericardial effusion of unknown aetiology and one article reporting five cases of acute pericarditis, with only one patient with pneumococcal pericarditis 5–7…”

Cardiovascular adverse events associated with immune checkpoint inhibitors: a meta-analysis

“…Thirdly, this study only included RCT, which can compare ICI with non ICI, dual drug ICI with single drug ICI. Despite existing statistics, it is still not possible to comprehensively evaluate the CAE risk of these patients, and some studies only report a specific CAE risk ( 31 , 32 ). In RCT, due to the strict requirements of the trial protocol, the trial needs to be discontinued in the event of severe cardiotoxicity, so very fewer cases can be collected to rechallenge of ICIs after the incidence of cardiac toxicity.…”