Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine‐induced pancreatitis

Bermejo, Fernando; López-Sanromán, Antonio; Taxonera, Carlos; Gisbert, Javier P.; Pérez-Calle, J.L.; Vera, Isabel; Menchén, Luís; Martín-Arranz, María Dolores; Opio, Verónica; Carneros, J.A.; Van-Domselaar, M.; Mendoza, Juan L.; Luna, Marta; López, Pilar Sáez; Calvo, Marta; Algaba, Alicia

doi:10.1111/j.1365-2036.2008.03746.x

Cited by 119 publications

(131 citation statements)

References 43 publications

Supporting

Mentioning

104

Contrasting

Unclassified

Order By: Relevance

“…La PA dans les MICI peut faire partie des manifestations extra-intestinales ou être secondaire aussi bien à l'AZA qu'a son métabolite la 6-MP ou à un traitement par dérivéss alicylés( m é salazine ou sulfasalazine) [1][2][3][4][5]. Le traitement immunosuppresseur par l'AZA ou la 6-MP au ne capacité certaine d'induire une PA ; cependant, la toxicité pancréatique est rare, estimée à 1,4 % [ 1,6,7].…”

Section: Discussionunclassified

“…La PA induite par l'AZA ou la 6-MP est généralement bénigne et répond bien à l'arrêt du médicament [6]. Le mécanisme des PA sous immunosuppresseur n'est pas clair ; cependant, plusieurs hypothèses avance la probabilité d'un mécanisme direct ou immuno-allergique [2][3]. Une enquête minutieuse permettrac ependant de déterminer l'imputabilité chronologique du médicament.…”

Section: Discussionunclassified

See 1 more Smart Citation

Pancréatite aiguë médicamenteuse secondaire à la 6-mercaptopurine : à propos d’un cas

Oubaha¹,

Eddoukani²,

Samlani³

et al. 2016

Hegel

View full text Add to dashboard Cite

Section: Discussionunclassified

Pancréatite aiguë médicamenteuse secondaire à la 6-mercaptopurine : à propos d’un cas

Oubaha¹,

Eddoukani²,

Samlani³

et al. 2016

Hegel

View full text Add to dashboard Cite

“…The occurrence of pancreatitis associated with ulcerative colitis has been reported in specific contexts: alcoholism, viral infection, abdominal trauma, cholelithiasis, malnutrition, hypertriglyceridemia, hyperparathyroidism and drug (mesalamine, azatioprine, 6-mercaptopurine, steroids and metronidazole) [1,2,4,[7][8][9][10][11]. In the absence of an evident cause pancreatitis including drug intake, pancreatitis is considered idiopathic.…”

Section: Discussionmentioning

confidence: 99%

“…It is usually due to use of drugs [1,2,4,5] like salicylates and immunosuppressants (azathioprine and 6 mercaptopurine). However, this association may sometimes be idiopathic [3][4][5][6] or as part of extraintestinal manifestations of inflammatory colitis which are very rare. We report the case of a patient who was admitted in our hospital for acute pancreatitis and next examinations have revealed an asymptomatic ulcerative colitis.…”

Section: Introductionmentioning

confidence: 99%

Acute pancreatitis revealing ulcerative colitis—A case report

Bousfiha¹,

Charif²,

Abkari³

et al. 2014

OJGas

View full text Add to dashboard Cite

The association of acute pancreatitis with ulcerative colitis [UC] has been described in the literature. It is usually induced by drugs, but sometimes it may be idiopathic. This association remains rare. We report the case of a patient who was treated in our department. Medical observation: Mr. KA, a 60-year-old man, was admitted in our unit for management of acute epigastric. The clinical examination at the admission was normal. After eliminating a cardiac or surgical cause, the diagnosis of acute pancreatitis was made on the basis of the presence of a serum lipase up to 5 times the normal level and pain intensity. An abdominal scanner tomography was performed for the assessment of the pancreatitis. It has shown a pancreatitis stage C associated with a thick rectosigmoidien that was discovered incidentally. Symptomatology was enriched 10 days after by the occurrence of rectal bleeding. A lower endoscopy was performed after the improvement of the pancreatitis and had shown an ulcerative colitis on pancolitis which was confirmed by biopsy. In order to search other causes of this pancreatitis, other tests were made [a biliary IRM, endoscopic ultrasonography, autoimmune tests] and the results were negative. We concluded an idiopathic pancreatitis. The ulcerative colitis was classified as moderate and the patient was put on oral corticosteroids with degression. The evolution was marked by a clinical and biological improvement of pancreatitis and colitis. Conclusion: The association of idiopathic pancreatitis with ulcerative colitis is rare. The case of our patient is the first case reported in our series with 400 cases of ulcerative colitis diagnosed in our service.

show abstract

“…In a study the use of Azathioprine and 6-mercaptopurine in IBD population resulted in increased risk of pancreatitis when compared to patients treated with these drugs for other causes [181].…”

Section: Pancreatitismentioning

confidence: 99%

A review of liver disorders in inflammatory bowel disease (IBD)

Shah¹,

Gupta²,

Borg³

2017

Clin Case Rep Rev

View full text Add to dashboard Cite

Disorders of the liver and the biliary tract are frequently the extraintestinal manifestations of inflammatory bowel disease (IBD). The etiology of these hepato-biliary conditions is deemed secondary to their shared pathogenesis, the chronic effects of a long term, ongoing inflammation of the bowels, along with the medications used to manage IBD. For up to 30% of patients with IBD, abnormal liver biochemical tests are present. Other, selected patients with IBD are followed for reactivation of hepatitis B, through guidelines only relatively recently in place. The vast realm of related clinical conditions does not always correspond well with IBD severity, which can range from mild hepatic insult to end-stage liver disease, necessitating liver transplantation. Hence it is critical to follow its presence, clinical course and long term consequences. Moreover, the management of these disorders is necessarily individualized, with some patients requiring frequent monitoring and others a more multi-disciplinary approach. Studies aimed at improving the outcomes of patients with IBD who experience associated liver and biliary tract disorders are now needed to assess early identification, possible screening approaches and more effective systems of referral. This article covers the evidence-based literature on topics detailing the co-existence of liver conditions in inflammatory bowel disease with a focus on its epidemiology, clinical manifestations, diagnosis and management.

show abstract

Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine‐induced pancreatitis

Abstract: SUMMARY BackgroundPancreatitis is a potentially severe condition. Patients with inflammatory bowel disease (IBD) seem to be at increased risk for acute pancreatitis.

Cited by 119 publications

References 43 publications

Pancréatite aiguë médicamenteuse secondaire à la 6-mercaptopurine : à propos d’un cas

Pancréatite aiguë médicamenteuse secondaire à la 6-mercaptopurine : à propos d’un cas

Acute pancreatitis revealing ulcerative colitis—A case report

A review of liver disorders in inflammatory bowel disease (IBD)

Contact Info

Product

Resources

About