1979
DOI: 10.1001/archderm.115.2.179
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Acute pancreatitis associated with long-term azathioprine therapy. Occurrence in a patient with systemic lupus erythematosus

Abstract: A 34-year-old woman with a 13-year history of systemic lupus erythematosus had been taking azathioprine (lmuran) for one year in an effort to control her cutaneous lesions and also as a steroid sparing agent. Acute pancreatitis developed, which we could not relate to her lupus, prednisone administration, viral illness, or other causes. We concluded it was due to azathioprine therapy and wish to report this unusual occurrence.

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Cited by 9 publications
(2 citation statements)
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“…(346) Serial ultrasound examinations have been proposed for early detection of asparaginase-induced acute pancreatitis, but results of this strategy are equivocal. (341,348) Azathioprine/6-mercaptopurine Numerous case-reports linking azathioprine, (25,29,52,(349)(350)(351)(352)(353)(354)(355)(356)(357)(358)(359)(360)(361)(362)(363)(364) and its metabolite 6-mercaptopurine (364)(365)(366)(367) to acute pancreatitis have been published, the majority with recurrence of pancreatitis after rechallenge. (25,(357)(358)(359)(360)(361)(362)(363)(364)(365) In addition, acute pancreatitis has been described in patients with systemic lupus erythematosus, (368,369) and in patients with renal transplants on immunosuppressive therapy that included azathioprine.…”
Section: Asparaginasementioning
confidence: 99%
“…(346) Serial ultrasound examinations have been proposed for early detection of asparaginase-induced acute pancreatitis, but results of this strategy are equivocal. (341,348) Azathioprine/6-mercaptopurine Numerous case-reports linking azathioprine, (25,29,52,(349)(350)(351)(352)(353)(354)(355)(356)(357)(358)(359)(360)(361)(362)(363)(364) and its metabolite 6-mercaptopurine (364)(365)(366)(367) to acute pancreatitis have been published, the majority with recurrence of pancreatitis after rechallenge. (25,(357)(358)(359)(360)(361)(362)(363)(364)(365) In addition, acute pancreatitis has been described in patients with systemic lupus erythematosus, (368,369) and in patients with renal transplants on immunosuppressive therapy that included azathioprine.…”
Section: Asparaginasementioning
confidence: 99%
“…[2] Some associate it with the use of corticosteroids [3] and azathioprine. [4,5] Some associate it with vasculitis and thrombosis seen in SLE, but most recently its said to be due to SLE than steroids. [6,7] Case Report A 20-year-old female patient known case of SLE with Evan's syndrome had multiple episodes of acute pancreatitis in 2 years and presented to us with a mass per abdomen [ Figure 1].…”
Section: Introductionmentioning
confidence: 99%