Acute Oral Toxicity Test of Nicotiana tabacum L. Bio-Oil Against Female Winstar Rats

Andjani, Hannah Natasha; Sentosa, Yogi; Yati, Kori; Fauzantoro, Ahmad; Gozan, Misri; Yoo, Young-Choon

doi:10.1088/1755-1315/353/1/012047

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…E. helioscopia was safe and produced no physiological alternations of vital organs and the biochemical parameters were also unchanged at the tested doses ( Saleem et al, 2016 ). S. anthelmia and N. tabacum did not affect the body weight and animal behavior and were considered to be non-toxic ( Ribeiro et al, 2017 ; Andjani et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review on Comparative Analysis, Toxicology, and Pharmacology of Medicinal Plants Against Haemonchus contortus

et al. 2021

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Background:Haemonchus contortus is an important pathogenic nematode parasite and major economic constraint of small ruminants in tropics and subtropics regions. This review is an attempt to systematically address the; (a) efficacy of different plants against H. contortus by in vitro and in vivo proof; (b) toxicology, mechanism of action, and active phyto-compounds involve in anti-haemonchiasis activity; (c) and comparative analysis of plant species evaluated both in vitro and in vivo. Methods: Online databases (Google Scholar, PubMed, Scopus, and ScienceDirect) were searched and published research articles (1980–2020) were gathered and reviewed. Results: A total of 187 plant species were reported belonging to 59 families and 145 genera with Asteraceae and Fabaceae being frequently used. Out of the total plant species, 171 species were found to be evaluated in vitro and only 40 species in vivo. Twenty-four species were commonly evaluated for in vitro and in vivo anti-haemonchiasis activity. Among the reported assays, egg hatching test (EHT) and fecal egg count reduction (FECR) were the most widely used assays in vitro and in vivo, respectively. Moreover, sheep were the frequently used experimental model in vivo. After comparative analysis, Lachesiodendron viridiflorum, Corymbia citriodora, Calotropis procera, and Artemisia herba-alba were found highly effective both in vitro and in vivo. L. viridiflorum inhibited enzymatic activities and metabolic processes of the parasite and was found to be safe without toxic effects. C. citriodora was moderately toxic in vivo, however, the plant extract produced promising nematicidal effects by causing muscular disorganization and changes in the mitochondrial profile. Additionally, C. procera and A. herba-alba despite of their high anti-haemonchiasis activity were found to be highly toxic at the tested concentrations. C. procera caused perforation and tegumental disorganization along with adult worm paralysis. Nineteen compounds were reported, among which anethole and carvone completely inhibited egg hatching in vitro and significantly reduced fecal egg count, decreased male length, and reproductive capacity of female in vivo. Conclusion: This review summarized different medicinal plants owing to nematicidal activities against H. contortus eggs, larvae, and adult worms. Plants like L. viridiflorum, C. citriodora, C. procera, and A. herba-alba, while compounds anethole and carvone having promising nematicidal activities and could be an alternative source for developing novel drugs after further investigation.

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Section: Discussionmentioning

confidence: 99%

A Systematic Review on Comparative Analysis, Toxicology, and Pharmacology of Medicinal Plants Against Haemonchus contortus

et al. 2021

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“…The leaf part of Artemisia afra , Azadirachta indica , Brucea antidysenterica , Buddleja polystachya , Eucalyptus Globulus , Gloriosa superba , Maytenus heterophylla , Nicotiana tabacum , and Ocimum lamiifolium are commonly used for the preparation of remedies used to treat epilepsy and related symptoms in Ethiopia. The acute toxicity studies conducted in the crude extracts, essential oils and bio-oils recapped the absence of gross behavioral, physical changes and signs of overt toxicity such as lacrimation, urination, muscle weakness and convulsions in different animal models [ 175 – 181 ]. As depicted in Table 5 , relatively higher LD 50 value greater than 5000 mg/kg of body weight were recorded for Artemisia afra , Azadirachta indica , Gloriosa superba , and Nicotiana tabacum extracts.…”

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

“…In addition, the stem extract caused pronounced toxicity at 1200 mg/kg [ 180 ] 27 Myrica salicifolia R HME Non-pregnant female mice 2000 > 2000 There are no visible signs of overt toxicity and mortality in mice treated with the extract at 2000 mg/kg [ 211 ] 28 Nicotiana tabacum L Bio-oil Female Wistar rats (130–140 g) 5000 > 5000 The rats exhibited no significant change in the body weight and behavior. In addition, there was no mortality of rats in the study period [ 181 ] 29 Ocimum lamiifolium L ME Swiss albino mice (27–36 g) 500, 1000 & 2000 ≥ 2000 The crude extract didn’t trigger gross visible signs of acute toxicity such as urination, hair erection, lacrimation, and reduction in feeding activity [ 194 ] 30 Olea europaea L ET Wistar rats of either sex (150–200 g) 2000 ≥ 2000 Oral administration of the extract didn’t cause any mortality or sign of toxicity at 2000 mg/kg of body weight during the study period [ 212 ] 31 Opuntia ficus-indica S HET White Sprague Dawley rats either sex 500, 1000 & 2000 – The rats exhibited no genotoxicity at all treatments regimens even at the maximum dose of 2000 mg/kg [ …”

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Birhan

2022

Chin Med

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Epilepsy is a common central nervous system (CNS) disorder that affects 50 million people worldwide. Patients with status epilepticus (SE) suffer from devastating comorbidities and a high incidence of mortalities. Antiepileptic drugs (AEDs) are the mainstream treatment options for the symptomatic relief of epilepsy. The incidence of refractory epilepsy and the dose-dependent neurotoxicity of AEDs such as fatigue, cognitive impairment, dizziness, attention-deficit behavior, and other side effects are the major bottlenecks in epilepsy treatment. In low- and middle-income countries (LMICs), epilepsy patients failed to adhere to the AEDs regimens and consider other options such as complementary and alternative medicines (CAMs) to relieve pain due to status epilepticus (SE). Plant-based CAMs are widely employed for the treatment of epilepsy across the globe including Ethiopia. The current review documented around 96 plant species (PS) that are often used for the treatment of epilepsy in Ethiopia. It also described the in vivo anticonvulsant activities and toxicity profiles of the antiepileptic medicinal plants (MPs). Moreover, the phytochemical constituents of MPs with profound anticonvulsant effects were also assessed. The result reiterated that a lot has to be done to show the association between herbal-based epilepsy treatment and in vivo pharmacological activities of MPs regarding their mechanism of action (MOA), toxicity profiles, and bioactive constituents so that they can advance into the clinics and serve as a treatment option for epilepsy.

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“…Furthermore, nicotine was assigned as a botanical insecticide with dissipation half-live of 2.51 days, thus making it readily dissipated from treated plants [45]. In addition, acute oral toxicity test showed that 5 g Nicotiana Tabacum L. bio-oil, with nicotine as the most dominant compound, per kg body weight of female Wistar rats was not toxic due to the absence of mortality and no significant change of the body weight and behavior of the rats [46]. It could be concluded that besides its far below toxicity level to humans and animals, the EHRE-Nt shows highly potential bioinsecticidal activity.…”

Section: E Intensity Of Cbbs Attackmentioning

confidence: 99%

Field Efficacy of Nicotiana tabacum L. var Virginia Extract against Coffee Borer Beetle (Hypothenemus hampei) Attacking Coffee Berries in Plantation Area

Harahap

Fauzantoro²,

Haryuni

et al. 2020

International Journal of Agronomy

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The extract of Nicotiana tabacum L. var Virginia origin of Ponorogo (EHRE-Nt) was applied under field conditions against the coffee borer beetle Hypothenemus hampei (CBB). Three extract formulations containing 150, 300, and 450 ml of EHRE-Nt in 100 liters of water were prepared and sprayed on 0.5 hectares each. A nontreatment was applied as a control on 0.5 hectares of plantation. The intensity of the CBB attacks was observed for six weeks on a Robusta coffee plantation in the Kalibening area, South Semarang, Central Java, Indonesia. An extract formulation containing 450 ml of EHRE-Nt resulted in the lowest intensity of CBB attacks from weeks one to six (1.6% to 2.2%). The attacks of the control field were 11.3% to 13.5%. The highest efficacy level of 85.4% was obtained with the 450 ml EHRE-Nt formulation. These results demonstrate that EHRE-Nt has potential as a bioinsecticide for coffee berries from CBB attacks.

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Acute Oral Toxicity Test of Nicotiana tabacum L. Bio-Oil Against Female Winstar Rats

Cited by 7 publications

References 10 publications

A Systematic Review on Comparative Analysis, Toxicology, and Pharmacology of Medicinal Plants Against Haemonchus contortus

A Systematic Review on Comparative Analysis, Toxicology, and Pharmacology of Medicinal Plants Against Haemonchus contortus

Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Field Efficacy of Nicotiana tabacum L. var Virginia Extract against Coffee Borer Beetle (Hypothenemus hampei) Attacking Coffee Berries in Plantation Area

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