Acute oral dexamethasone administration reduces levels of orphan GPCR glucocorticoid-induced receptor (GIR) mRNA in rodent brain: potential role in HPA-axis function

Adams, F. Dennette

doi:10.1016/s0169-328x(03)00280-8

Cited by 28 publications

(32 citation statements)

References 21 publications

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“…Glucocorticoid sensitivity during ischemia may be directly linked to its receptor expression, which is extensively distributed throughout the brain (Adams et al 2003). These results indicate that maternal diet may affect the distribution of GR in the brain.…”

Section: Discussionmentioning

confidence: 82%

Maternal high-fat diet influences stroke outcome in adult rat offspring

Lin

Shao

Zhou

et al. 2015

Journal of Molecular Endocrinology

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Diet-induced epigenetic modifications in early life could contribute to later health problem. However, it remains to be established whether high-fat diet (HFD) consumption during pregnancy and the suckling period could predispose the offspring to stroke. The present study investigated the influence of maternal HFD on stroke outcome in adult offspring. Female Sprague-Dawley rats were fed a normal diet (5.3% fat) or a HFD (25.7% fat), just before pregnancy until the end of lactation. Male offspring were fed with the control diet or the HFD after weaning, to form four groups (control offspring fed with the control diet (C/C) or the HFD (C/HFD) and offspring of fat-fed dams fed with the control diet (HFD/C) or the HFD (HFD/HFD)). The offspring received middle cerebral artery occlusion on day 120 followed by behavioral tests (neurological deficit score, staircase-reaching test and beam-traversing test), and infarct volumes were also calculated. We found that the HFD/C rats displayed larger infarct volume and aggravated functional deficits (all P!0.05), compared with the C/C rats, indicating that maternal fat-rich diet renders the brain more susceptible to the consequences of ischemic injury. Moreover, maternal HFD offspring displayed elevated glucocorticoid concentrations following stroke, and increased glucocorticoid receptor expression. In addition, adrenalectomy reversed the effects of maternal HFD on stroke outcome when corticosterone was replaced at baseline, but not ischemic, concentrations. Furthermore, expression of brain-derived neurotrophic factor (BDNF) in the ipsilateral hippocampus was decreased in the HFD/C offspring (P!0.05), compared with the C/C offspring. Taken together, maternal diet can substantially influence adult cerebrovascular health, through the programming of central BDNF expression and the hypothalamic-pituitary-adrenal axis.

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Section: Discussionmentioning

confidence: 82%

Maternal high-fat diet influences stroke outcome in adult rat offspring

Lin

Shao

Zhou

et al. 2015

Journal of Molecular Endocrinology

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“…In humans, the most abundant GPR83-encoding transcript corresponds to the homolog of mouse isoform 1 (24). In mouse brain, GPR83 expression is increased after chronic amphetamine treatment (35) and reduced by short-term dexamethasone treatment (36). GPR83 knockout mice show a reduction in stress-evoked anxiety and delayed spatial learning in the Morris water maze (37).…”

Section: Discussionmentioning

confidence: 99%

Identification of GPR83 as the receptor for the neuroendocrine peptide PEN

et al. 2016

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PEN is an abundant peptide in the brain that has been implicated in the regulation of feeding. We identified a receptor for PEN in mouse hypothalamus and Neuro2A cells. PEN bound to and activated GPR83, a G protein (heterotrimeric guanine nucleotide–binding protein)–coupled receptor (GPCR). Reduction of GPR83 expression in mouse brain and Neuro2A cells reduced PEN binding and signaling, consistent with GPR83 functioning as the major receptor for PEN. In some brain regions, GPR83 colocalized with GPR171, a GPCR that binds the neuropeptide bigLEN, another neuropeptide that is involved in feeding and is generated from the same precursor protein as is PEN. Coexpression of these two receptors in cell lines altered the signaling properties of each receptor, suggesting a functional interaction. Our data established PEN as a neuropeptide that binds GPR83 and suggested that these two ligand-receptor systems—PEN-GPR83 and bigLEN-GPR171—may be functionally coupled in the regulation of feeding.

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“…Among these is GPR83 (also known as GIR, GPR72, or JP05), originally identified as a stress–response element from a murine thymoma cDNA library treated with glucocorticoids and forskolin (Harrigan et al, 1989, 1991; Baughman et al, 1991), and subsequently shown to be highly expressed in several brain regions including the hypothalamus, the cortex, the thalamus, the hippocampus, and the amygdala (Pesini et al, 1998; Brezillon et al, 2001; Wang et al, 2001; Adams et al, 2003; Sah et al, 2005). GPR83 shares some homology with a variety of known peptide receptors, including the neuropeptide Y2 receptor.…”

Section: Two Interesting Orphan Gpcrs With Hypothalamic Expressionmentioning

confidence: 99%

Molecules affecting hypothalamic control of core body temperature in response to calorie intake

Bartfai¹,

Conti²

2012

Front. Gene.

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Core body temperature (CBT) and calorie intake are main components of energy homeostasis and two important regulators of health, longevity, and aging. In homeotherms, CBT can be influenced by calorie intake as food deprivation or calorie restriction (CR) lowers CBT whereas feeding has hyperthermic effects. The finding that in mice CBT prolonged lifespan independently of CR, suggested that the mechanisms modulating CBT may represent important regulators of aging. Here we summarize the current knowledge on the signaling molecules and their receptors that participate in the regulation of CBT responses to calorie intake. These include hypothalamic neuropeptides regulating feeding but also energy expenditure via modulation of thermogenesis. We also report studies indicating that nutrient signals can contribute to regulation of CBT by direct action on hypothalamic preoptic warm-sensitive neurons that in turn regulate adaptive thermogenesis and hence CBT. Finally, we show the role played by two orphans G protein-coupled receptor: GPR50 and GPR83, that were recently demonstrated to regulate temperature-dependent energy expenditure.

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Acute oral dexamethasone administration reduces levels of orphan GPCR glucocorticoid-induced receptor (GIR) mRNA in rodent brain: potential role in HPA-axis function

Cited by 28 publications

References 21 publications

Maternal high-fat diet influences stroke outcome in adult rat offspring

Maternal high-fat diet influences stroke outcome in adult rat offspring

Identification of GPR83 as the receptor for the neuroendocrine peptide PEN

Molecules affecting hypothalamic control of core body temperature in response to calorie intake

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