Acute Optic Neuropathy in Behçet Disease

Yalçındağ, F Nilüfer; Yılmaz, Nusret; Tekeli, Oya; Özdemir, Oya

doi:10.1177/112067210401400623

Cited by 22 publications

(16 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…consecutive to the retinal disease) have been well described in patients with Behçet’s disease [2, 9]. However, acute optic neuropathy is uncommon in these patients [1,2,3,4,5,6,7]. In 1976, Scouras and Koutroumanos [1 ]were the first to describe anterior ischaemic optic neuropathy associated with Behçet’s disease in two patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acute Optic Neuropathy in Patients with Behçet’s Disease

Voros¹,

Sandhu²,

Pandit³

2006

Ophthalmologica

View full text Add to dashboard Cite

Although acute optic neuropathy has been rarely reported in patients with Behçet’s disease, a detailed description of its clinical course is lacking. We report in detail the course of acute optic neuropathy in two patients with Behçet’s disease. Our experience suggests that it can be bilateral, can affect both eyes simultaneously, and can be recurrent. The severity of the visual loss and its recovery can be very variable even in the same patient. Early recognition of this entity and treatment with high-dose systemic corticosteroids may limit the degree of permanent visual loss. However, the optimal treatment has not been established.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Although acute optic neuropathy has been rarely reported in patients with Behçet’s disease [1,2,3,4,5,6,7], a detailed description of its clinical course is lacking. We report in detail the course of acute optic neuropathy in two patients with Behçet’s disease.…”

Section: Introductionmentioning

confidence: 99%

Acute Optic Neuropathy in Patients with Behçet’s Disease

Voros¹,

Sandhu²,

Pandit³

2006

Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…This may be an interesting tool for the misdiagnosed inflammatory ON which may be totally asymptomatic as in our patients 7 and 8 (Table I). Only a handful of such cases have been published original paper (12)(13)(14)(15)(16)(17)(18)(19)(20), with one case with histopathology showing gliosis and demyelination within the nerve (12). Pathological features include disseminated softening foci with mild loss of myelin and glial proliferation, perivascular lymphocyte cuffing and variable wallerian degeneration of white matter tracts (1).…”

Section: N Discussionmentioning

confidence: 99%

Inflammatory optic neuropathy in Behçet’s disease

Khanfir

Belfeki

Saïd³

et al. 2016

Reumatismo

View full text Add to dashboard Cite

summary Inflammatory optic neuropathy (ON) is a rare event in Behçet's disease (BD). We report herein a series of ten BD Tunisian patients with ON and describe its clinical features among them. A retrospective review of BD patients (International Study Group for BD criteria) was performed. The patients were divided into two groups: those presenting an inflammatory ON, and those none. The diagnosis of inflammatory ON was based on the clinical examination, visual field and visual evoked potentials. We analyzed the characteristics of the two groups. Ten patients (2.3%) presented an inflammatory ON among our 440 patients. Inflammatory ON was inaugural in 8 cases. Clinical manifestations were as follows: blurred vision (7 cases) and periorbital pain (3 cases). In two cases, the patients did not complain from ophthalmological symptoms. The fundus revealed a papilledema (2 cases), papillary pallor (4 cases), and was normal in 5 cases. Visual field realized in only three patients showed a scotoma in all cases. Visual evoked potentials revealed increased latency in all cases. All patients received corticosteroids associated to an immunosuppressive agent. The comparative study between the two groups revealed that inflammatory ON was significantly more associated to neurological involvement (p<0.0001) and that the disease was more severe in the ON group (p<0.0001). Inflammatory ON in BD is rare and may occur at an early stage of the clinical course of the disease. Its prevalence is certainly underestimated. A systematic visual evoked potential may be interesting as a screening tool.

show abstract

“…21 Primer olarak optik sinir tutulumu Behçet hastalığı için karakteristik olmasa da olgu sunumları olarak çeşitli çalışmalarda gösterilmiştir. 11,14,15,[22][23][24] Desmond yaptığı meta-analiz çalışmasında literatürde izole optik sinir tutulumu olan 20 Behçet hastasını incelemiş ve 11 (%55)'inde tek taraflı, 4 (%20)'ünde bilateral ve eş zamanlı, 5 (%25)'inde ise bilateral ardışık optik sinir tutulumu olduğunu rapor etmiştir. 25 Kansu ve ark., Behçet hastalığına bağlı izole optik sinir tutulumu olan 32 ve 35 yaş-larında 2 erkek ve 22 yaşında 1 kadın olmak üzere 3 hasta yayınlamıştır.…”

Section: Discussionunclassified

“…ise tek taraflı akut anterior iskemik optik nöropatisi olan 47 yaşında bir erkek hasta yayınlamışlardır. 24 Behçet hastalığı ile ilişkili primer olarak optik sinir tutulumu mekanizması tam olarak bilinmemekle birlikte, çalışmalarda uveal trakt ya da retinadan kaynaklanan inflamatuar sürecin optik sinire sekonder invazyonu, optik siniri besleyen damarların vaskülite bağlı etkilenmesi sonucunda meydana gelen iskemik süreç ve iskemiye sekonder olarak gelişen demiyelinizasyon patofizyoloji için öne sürü-len hipotezlerdir. 9,24,28 Sunulan iki olguda da uveal tutulumun olmaması ve optik sinir başının ödemli olması nedeni ile muhtemel mekanizmanın optik sinirin beslenmesini sağlayan damarların vaskülitik süreçten etkilenmesi olduğu düşünülmektedir.…”

Section: Discussionunclassified