Acute normovolemic hemodilution reduced the frequency and amount of perioperative allogeneic blood transfusion in pediatric and adolescent scoliosis surgery: a retrospective observational study

Uchida, Satoshi; Kinoshita, Haruhito; Takekawa, Daiki; Saito, Junichi; Hirota, Kazuyoshi

doi:10.1007/s00540-022-03078-z

Cited by 1 publication

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acute normovolemic hemodilution (ANH) is a good blood conservation technique that has been widely used in clinical practice [ 4 ]. ANH involves removing autologous blood from a patient after inducing anesthesia while diluting blood with an equal volume of plasma substitute-artificial colloid fluid, and reducing blood loss by decreasing the loss of active components of erythrocytes during bleeding, then returning the autologous blood containing whole blood to the patient immediately upon completion of the surgical procedures [ 5 ]. This method can improve microcirculation that can increase oxygen supply to tissues and organs, [ 6 ] reduce the need for allogeneic blood transfusion [ 7 ] thereby mitigating complications such as infection, transfusion reaction, and disease transmission caused by allogeneic blood transfusion, [ 8 ] and effectively save blood resources.…”

Section: Introductionmentioning

confidence: 99%

Effect of acute normovolemic hemodilution on anesthetic effect, plasma concentration, and recovery quality in elderly patients undergoing spinal surgery

Liu,

Bai,

Yin

et al. 2023

BMC Geriatr

View full text Add to dashboard Cite

Objective To explore the effect of acute normovolemic hemodilution (ANH) on the anesthetic effect, plasma concentration, and postoperative recovery quality in elderly patients undergoing spinal surgery. Methods A total of 60 cases of elderly patients aged 65 to 75 years who underwent elective multilevel spinal surgery were assigned randomly into the ANH group (n = 30) and control group (n = 30). Hemodynamic and blood gas analysis indexes were observed and recorded before ANH (T1), after ANH (T2), immediately after postoperative autologous blood transfusion (T3), 10 min (T4), 20 min (T5), 30 min (T6), 40 min (T7), and 50 min (T8) after the transfusion, and at the end of the transfusion (i.e., 60 min; T9). At T3 ~ 9, bispectral index (BIS) and train-of-four (TOF) stimulation were recorded and the plasma propofol/cisatracurium concentration was determined. The extubation time and recovery quality were recorded. Results The ANH group presented a lower MAP value and a higher SVV value at T2, and shorter extubation and orientation recovery time (P < 0.05) compared with the control group. BIS values at T8 and T9 were lower in the ANH group than those in the control group (P < 0.05). TOF values at T7 ~ 9 were lower in the ANH group than those in the control group (P < 0.05). There were no statistically significant differences in the postoperative plasma concentrations of propofol and cisatracurium between the groups (P > 0.05). Conclusion During orthopedic surgery, the plasma concentration of elderly patients is increased after autologous blood transfusion of ANH, and the depth of anesthesia and muscle relaxant effect are strengthened, thus leading to delayed recovery of respiratory function and extubation.

show abstract