Acute neurologic disorder in Crohn's disease: A rare life‐threatening complication

Machado, Joana; Ministro, Paula; Cancela, Eugénia; Araújo, Ricardo; Castanheira, António; Silva, Américo

doi:10.1016/j.jpg.2013.10.006

Cited by 1 publication

(2 citation statements)

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“…41,42 In humans, conditions that commonly disrupt nutrient absorption include Crohn's disease, pyloric stenosis, peptic ulcers or chronic diarrhoea, which have all been linked to development of WE. [43][44][45][46] Bariatric and GI surgery accounts for a large proportion of cases of WE due to decreased thiamine absorption. 2 Cases of WE after bariatric surgery for weight loss have greatly increased in the past two decades.…”

Section: Conditions Of Decreased Gastrointestinal (Gi) Absorption Of mentioning

confidence: 99%

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Don’t seek, don’t find: The diagnostic challenge of Wernicke’s encephalopathy

Kohnke

Meek

2020

Ann Clin Biochem

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Wernicke’s encephalopathy is caused by thiamine deficiency and has a range of presenting features, including gait disturbance, altered cognitive state, nystagmus and other eye movement disorders. In the past, Wernicke’s encephalopathy was described almost exclusively in the alcohol-dependent population. However, in current times, Wernicke’s encephalopathy is also well recognized in many other patient groups, including patients following bariatric surgery, gastrointestinal surgery, cancer and pancreatitis. Early recognition of Wernicke’s encephalopathy is vital, as prompt treatment can restore cognitive or ocular function and can prevent permanent disability. Unfortunately, Wernicke’s encephalopathy is often undiagnosed – presumably because it is relatively uncommon and has a variable clinical presentation. Clinical biochemists have a unique role in advising clinicians about potential nutritional or metabolic causes of unexplained neurological symptoms and to prompt consideration of thiamine deficiency as a potential cause in high-risk patient groups. The aim of this review is to summarize the clinical features, diagnosis and treatment of Wernicke’s encephalopathy and to highlight some non-traditional causes, such as after bariatric surgery.

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Section: Conditions Of Decreased Gastrointestinal (Gi) Absorption Of mentioning

confidence: 99%

“…41,42 In humans, conditions that commonly disrupt nutrient absorption include Crohn’s disease, pyloric stenosis, peptic ulcers or chronic diarrhoea, which have all been linked to development of WE. 43–46…”

Section: Medical Conditions Associated With Wementioning

confidence: 99%

Don’t seek, don’t find: The diagnostic challenge of Wernicke’s encephalopathy

Kohnke

Meek

2020

Ann Clin Biochem

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show abstract

Acute neurologic disorder in Crohn's disease: A rare life‐threatening complication

Cited by 1 publication

References 13 publications

Don’t seek, don’t find: The diagnostic challenge of Wernicke’s encephalopathy

Don’t seek, don’t find: The diagnostic challenge of Wernicke’s encephalopathy

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