Acute myocardial infarction in young and very old Chinese adults: clinical characteristics and therapeutic implications

Teng, Jeng Kai; Lin, Long-Yau; Tsai, Liang‐Miin; Kwan, Chi-Ming; Chen, Jyh-Hong

doi:10.1016/0167-5273(94)90063-9

Cited by 32 publications

(29 citation statements)

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“…The clinical features and outcomes of acute myocardial infarction (AMI) in the young are considered to be different from those in the non-young. [1][2][3][4][5][6][7][8][9] As diet patterns and lifestyles in the young are different from the non-young, 10,11) specific and unique considerations are needed for young AMI patients. It is important to elucidate the clinical features and outcomes of AMI in young patients.…”

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Clinical Features of Myocardial Infarction in Young Japanese Patients

et al. 2013

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SummaryClinical features and outcomes of acute myocardial infarction (AMI) in the young have been poorly investigated. The aim of this study was to investigate the clinical features and hospital outcomes of AMI in young Japanese. We conducted a case-control study. A total of 53 consecutive AMI patients whose age was ≤ 45 years old were assigned to the young group and 106 AMI patients whose age was > 45 years old were assigned to the non-young group. We compared the clinical features and hospital outcomes between the two groups. Compared with the non-young group, the young group was associated with male sex, hyperlipidemia, current smoking, being overweight, single vessel disease, and Killip class I on admission. There were no differences in the length of hospital stay or major adverse cardiac events between the groups. However, mortality and ventricular rupture were slightly lower in the young. In conclusion, young AMI patients had clinical characteristics different to those of the non-young patients. Compared to non-young patients, modifiable risk factors such as smoking, hyperlipidemia, and being overweight were associated with young AMI patients. (Int Heart J 2013; 54: 123-128) Key words: Angioplasty, Age, Ischemic heart disease A lthough the incidence of coronary artery disease in the young is still lower than that in the non-young, 1,2) coronary artery disease in the young has been increased recently. The clinical features and outcomes of acute myocardial infarction (AMI) in the young are considered to be different from those in the non-young. [1][2][3][4][5][6][7][8][9] As diet patterns and lifestyles in the young are different from the non-young, 10,11) specific and unique considerations are needed for young AMI patients. It is important to elucidate the clinical features and outcomes of AMI in young patients. We conducted a case-control study to elucidate the clinical features of AMI in young patients. MethodsCases and controls: We identified acute myocardial infarction patients from the hospital records of our medical center from January 2007 to March 2012. A diagnosis of AMI consisted of elevation of creatine kinase (at least 2-fold above the normal upper limit), and the presence of 1 of the following 2 criteria; (1) persistent chest pain or (2) ST-segment elevation or depression in the 12-lead electrocardiogram compatible with AMI. During the study period, 53 consecutive AMI patients whose age was ≤ 45 years old were assigned to the young group (Case group). 8,12) The control patients were selected from our AMI patients whose age was > 45 years old during the same study period. We designed the study so the ratio of cases to controls would be 1 to 2. To minimize the selection bias, consecutive AMI patients whose age was > 45 years old were assigned to the non-young group (Control group). In addition, to minimize any bias related to the therapeutic strategy for AMI, consecutive selection was conducted for each year. This study was approved by the institutional review board. PCI procedures: PCI was p...

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Clinical Features of Myocardial Infarction in Young Japanese Patients

et al. 2013

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“…7 Það er því tímabaert að kanna á ný stöðu mála í yngsta sjúklingahópnum sem í fyrri rannsókninni reyndist hafa margs konar sérstöðu miðað við aðra aldurshópa 6 en þó áþekka því sem lýst hefur verið í mörgum erlendum rannsóknum. [3][4][5][8][9][10][11][12][13][14] Markmið þessarar rannsóknar var því að kanna hver þróunin hefur orðið meðal ungra þolenda alvarlegs kransaeðasjúkdóms og áherslan, eins og í fyrri rannsókninni, á nýgengi, áhaettuþaetti og afdrif, sem og á útbreiðslu kransaeðaþrenginganna.…”

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Brátt hjartadrep á Íslandi í fertugum og yngri 2005-2009

Magnusson¹,

Agnarsson²,

Guðnason³

et al. 2017

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“…In fact, the smoking behavior alone is a potent risk factor for MI at a young age (Teng et al, 1994;Liu et al, 2003). Smoking, in supporting of our current in vitro and in vivo findings, can also reduce the activities of DHET and may explain partially the possible mechanism for the smoking behavior alone or its interaction with gene variation to change the CYP2J2 gene activity.…”

Section: Modification Effects Of Smoking Cessation and Its Associatiomentioning

confidence: 99%

“…In the vasculature, EETs are key components of cellular signaling cascades that cumulate in the activation of smooth muscle potassium channels to induce membrane hyperpolarization and vascular relaxation. Smoking habit might induce the hypercoagulable state by increasing platelet aggregability and had been recognized as a potent risk factor for premature MI (Teng et al, 1994).…”

Section: The Synergistic Effects Of the Cyp2j2 G-50t Genotype And Smomentioning

confidence: 99%

“…Of the common environmental factors known to be a ssoc iated with risk of a cute MI, smoking is widely acknowledged to make a major contribution (Manson et al, 1992;Teng et al, 1994). Smoking can disturb lipoprotein metabolism by increasing insulin resistance and lipid intolerance, and is implicated in the production of small dense low-density lipoprotein (Craig et al, 1989;Eliasson et al, 1997;Barua et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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