Acute myelomonocytic leukemia presenting as a benign-appearing cutaneous eruption

Horlick, H. P.

doi:10.1001/archderm.126.5.653

Cited by 19 publications

(16 citation statements)

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“…It most commonly presents as multiple, firm, freely movable violaceous, blue or red nodules approximately 1 to 2.5 cm in diameter, giving a "blueberry muffin baby" appearance. There have also been reports of tumours, papules, macules, plaques and ulcers (6). The colour of the lesions is also highly variable.…”

Section: Discussionmentioning

confidence: 99%

“…CL is defined as leukaemia that is present at birth or develops within the first month of life (1,4,5). Leukaemia cutis (LC), which is characterised by infiltration ofthe skin by immature malignant haematopoietic cells, is a common feature in CL, occurring in up to 25-30% of cases (1,4,6). CL and congenital LC (CLC) have similar sex distributions, with a 2:1 male-to-female ratio (1,3).…”

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confidence: 99%

“…Aleukaemic LC is a term applied to describe a form of leukaemia in which infiltration ofthe skin by leukaemic cells occurs before the appearance ofthe disease in the peripheral blood or bone marrow (6). Aleukaemic CLC is rarely reported in the literature.…”

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confidence: 99%

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Aleukaemic Congenital Leukaemia Cutis: A Critical Primary Sign of Systemic Disease

Sotiriou¹,

Manousari²,

Apalla³

et al. 2011

Acta Derm Venerol

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Aleukaemic Congenital Leukaemia Cutis: A Critical Primary Sign of Systemic Disease

Sotiriou¹,

Manousari²,

Apalla³

et al. 2011

Acta Derm Venerol

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“…ALC defines a rare form of leukemia in which the invasion of leukemic blasts into the skin occurs at least one month prior to the appearance of disease in peripheral blood or bone marrow [21]. Cases of ALC reported thus far show little or no harmony in their clinical presentation.…”

Section: Discussionmentioning

confidence: 99%

Aleukemic Leukemia Cutis Manifesting with Disseminated Nodular Eruptions and a Plaque Preceding Acute Monocytic Leukemia: A Case Report

Yonal¹,

Hindilerden

Coşkun³

et al. 2011

Case Rep Oncol

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Aleukemic leukemia cutis (ALC), a discrete tumor of leukemic cells involving the skin, may be the first manifestation of acute myeloid leukemia, preceding the onset in marrow and blood by months and years. ALC is often difficult to diagnose and is associated with a dismal prognosis. A 63-year-old male presented with nodular swellings on the face, a plaque extending over the right shoulder and multiple enlarged cervical lymph nodes. The skin biopsy of the plaque lesion showed a diffuse neoplastic infiltration extending from the dermis to subcutaneous tissue with diffuse positivity for myeloperoxidase and focal positivity for CD34 on immunohistochemical staining. The diagnosis was leukemia cutis. One month later, acute monocytic leukemia (FAB AML-M5b) was diagnosed. The patient died on the seventh month of diagnosis.

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“…Leukemia cutis (LC) consists of cutaneous infiltrates by leukemic cells and is an uncommon manifestation of leukemia [2, 3]. In childhood and adult leukemia, LC typically develops late in the course of the disease and is strongly associated with the presence of extramedullary disease at other sites [4].…”

Section: Introductionmentioning

confidence: 99%

Diffuse Calcinosis cutis in a Patient with Congenital Leukemia and Leukemia cutis

Lestringant

Masouyé²,

El-Hayek

et al. 2000

Dermatology

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We report an unusual case of congenital leukemia with leukemia cutis (LC) and diffuse calcinosis cutis. A newborn girl presented with widespread dusky red and yellowish cutaneous nodules and papules. Bone marrow morphology was consistent with the diagnosis of acute monocytic leukemia of the FAB M5 type. Skin biopsy specimens confirmed the presence of a leukemic infiltrate and revealed calcium salt deposition in the papillary and reticular dermis. Calcinosis was diffuse in the whole skin but spared other organs. Vascular calcification was not present. Serum calcium levels oscillated between 2.5 and 2.86 mmol/l, and phosphorus, parathyroid hormone and 25-hydroxyvitamin D₃ levels were normal. There were diffuse osteoporosis and spontaneous fractures of small tubular bones. The patient responded to chemotherapy but, following consolidation treatment, developed sepsis and died at 120 days of age. Congenital leukemia is rare and LC is uncommon. Hypercalcemia may be a complication of leukemia, which leads to multiorgan metastatic calcification. Despite the absence of frank hypercalcemia, the presence of bone lesions suggests that the patient’s calcinosis cutis was of the metastatic type. However, the cutaneous leukemic infiltrate may also represent a triggering factor for calcium deposition in the skin.

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Acute myelomonocytic leukemia presenting as a benign-appearing cutaneous eruption

Cited by 19 publications

References 0 publications

Aleukaemic Congenital Leukaemia Cutis: A Critical Primary Sign of Systemic Disease

Aleukaemic Congenital Leukaemia Cutis: A Critical Primary Sign of Systemic Disease

Aleukemic Leukemia Cutis Manifesting with Disseminated Nodular Eruptions and a Plaque Preceding Acute Monocytic Leukemia: A Case Report

Diffuse Calcinosis cutis in a Patient with Congenital Leukemia and Leukemia cutis

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