Acute myeloid leukemia: Correlation of cytogenetics and outcome in resource limited setting

Pediatric Acute Myeloid Leukemia in India: A Systematic Review

“…A total of 1,210 patients were included from the 19 studies. 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 Three of the 19 studies also included patients with acute promyelocytic leukemia (APML). 19 21 22 Eight studies were published before 2015, while the remaining 11 studies were published in or after 2015.…”

“…8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 Three of the 19 studies also included patients with acute promyelocytic leukemia (APML). 19 21 22 Eight studies were published before 2015, while the remaining 11 studies were published in or after 2015. The various studies included patients between 1 and 19 years of age.…”

“…Data regarding induction chemotherapy were available from 17 studies. 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 25 26 Anthracycline-based regimens were used for induction in all studies. 3 + 7 regimen consisting of daunorubicin (45–60 mg/m 2 /day) and cytarabine (100–200 mg/m 2 /day) was the standard regimen used in nine studies, while MRC AML based regimens that included an additional third agent (etoposide) were used in seven studies.…”

“…Six of the 17 studies used maintenance chemotherapy. 13 14 16 20 21 26 Six studies mentioned regarding HSCT (Reference: 8,9,16,17,22,25). A total of 20 patients underwent HSCT in these studies, 15 in CR1 and another 5 in CR2.…”

“…Data for OS was available from 16 studies. 8 9 10 11 13 14 15 16 17 18 19 20 21 23 24 25 Philip et al reported an OS of 70% with a follow-up of 7 months. Remaining 15 studies had OS ranging between 15 and 66%.…”