Acute liver failure in the setting of herpes simplex virus and coexistent acute fatty liver of pregnancy

Wilder, Julius; Chang, Sydney; Cardona, Diana M.; Patel, Keyur; Brady, Carla W.

doi:10.5430/crcp.v2n2p89

Cited by 3 publications

(6 citation statements)

References 22 publications

(37 reference statements)

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“…HSV hepatitis is rare and accounts for only 1% of all acute liver failure cases and only 2% of all viral causes of acute liver failure [4][5][6]. Several risk factors are associated with the development of HSV hepatitis, including burns, cancer, pregnancy, or immune-modulation drugs: the similarity in each of these conditions is that the host immune defenses are compromised [7].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, disseminated intravascular coagulopathy is a late sign of the disease. Ninety percent of patients with HSV hepatitis have a characteristic liver profile, known as "anicteric hepatitis," which refers to a liver profile showing a significant increase in transaminases (100-1,000 fold) with relatively normal or low bilirubin [4]. There may be a marked elevation of AST, greater than that of ALT [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…Prompt diagnosis of non-acetaminophen fulminant hepatic failure should not only include studies of common hepatitis viruses such as hepatitis A and B, Epstein-Barr virus, and cytomegalovirus, but also HSV [4].…”

Section: Discussionmentioning

confidence: 99%

“…Early diagnosis may be difficult when the characteristic vesicular rash is absent, early symptoms are often nonspecific, and there is a lack of history of genital herpes infection [4,5]. Here, we present a female patient with hepatitis induced by HSV.…”

Section: Introductionmentioning

confidence: 97%

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Herpes Simplex Virus Hepatitis Treated with Acyclovir

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Herpes Simplex Virus Hepatitis Treated with Acyclovir

et al. 2016

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“…Two rare causes of hepatitis, especially fulminan (rare complications of the herpes simplex virus) such as HSV-1 and HSV 2 are comorbid in the same patient [124]. Pregnancy in women with cirrhosis of the liver, portal hypertension, or esophageal varices leads to worse pregnancy and may warrant closer antenatal monitoring and patient counseling [125]. Different levels of bile acid and carnitine circulation can be altered in patients with primary biliary cirrhosis (PBC) as potential biomarkers [126].…”

Section: Situmorang and Ilyasmentioning

confidence: 99%

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

Situmorang

Ilyas

2018

Asian J Pharm Clin Res

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Preeclampsia (PE) have a high risk of pregnancy disorder and can cause liver and kidney disease. PE is a dangerous disease in Indonesia with a high risk of cardiovascular death. PE has biomarkers such as proteinuria, blood pressure, dipstick test, renin-angiotensin system, adipsin, calcium/ creatinine (Cr) ratio, albumin/Cr ratio, and uric acid. Apoptosis occurs in the placenta’s PE, where trophoblasts invade and overhaul the uterine spiral artery in the epidermal growth factor signaling system, and the expression of miRNA in PE is targeting genes in a variety of pathophysiological processes can cause kidney and hepatic disease. In this review, we will discuss role of HSP, miRNA, Immunology cell and the risk of kidney and hepatic disease of patient of Preeclampsia.

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Empirical treatment with parenteral acyclovir in a child with herpes simplex virus hepatitis and acute lymphoblastic leukemia

Faqih

Alfaqih

Salami

et al. 2018

IDCases

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IntroductionHepatitis secondary to Herpes Simplex Virus (HSV) infection is a complication that often leads to fatal hepatic failure. Early treatment with the anti-viral drug, acyclovir, is life-saving. In view of the non-specific nature of the signs and symptoms associated with HSV hepatitis, diagnosis is often made late during the course of the disease; a factor that largely contributes to the high mortality rate of this treatable disease complication. There is thus a growing consensus in the field to initiate empirical treatment with acyclovir once suspicion of HSV hepatitis is raised even before reaching a conclusive diagnosis.Presentation of caseWe present clinical evidence on the benefit of starting empirical acyclovir treatment on the outcome of patients suffering from HSV hepatitis. We report two cases of HSV hepatitis in children with cancer. One case presented with fulminant hepatitis which was fatal and the diagnosis was only reached post mortem. In the second case, there was enough suspicion of HSV hepatitis to start early empirical acyclovir therapy. The diagnosis was confirmed 48 hours following the initiation of treatment and the early intervention with anti-virals proved to be life-saving.DiscussionIn both cases above, the following symptoms were shared; fever, elevated transaminase levels and mucositis without clear cutaneous lesions. HSV hepatitis should thus be considered in the differential diagnosis of immuonocomprimised patients exhibiting the above symptoms.ConclusionDue to the frequent delay in HSV diagnosis and the safety of acyclovir, we recommend empirically administering acyclovir in patients suspected of HSV hepatitis.

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Acute liver failure in the setting of herpes simplex virus and coexistent acute fatty liver of pregnancy

Cited by 3 publications

References 22 publications

Herpes Simplex Virus Hepatitis Treated with Acyclovir

Herpes Simplex Virus Hepatitis Treated with Acyclovir

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

Empirical treatment with parenteral acyclovir in a child with herpes simplex virus hepatitis and acute lymphoblastic leukemia

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