Acute kidney injury in ventilated patients with coronavirus disease-2019 pneumonia: A single-center retrospective study

Elkholi, Mohamed Hamed; Alrais, Zeyad Faoor; Algouhary, Abdallah Reda; Al-Taie, Muthana Salim; Sawwan, Amr Abass; Khalafalla, Abdelnasser Ahmed; Beniamein, Maged Mohsen; Alkhouly, Adel Elsaid; Shoaib, Mohamed Ibrahim; Alkholy, Hesham Elsaid; Hadi, Ammar Mohamed Abdel; Alkhair, Ahmed Tarek Abu

doi:10.4103/ijciis.ijciis_194_20

Cited by 3 publications

(12 citation statements)

References 57 publications

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“…Todos os estudos incluídos foram publicados em língua inglesa, entre 2020 e 2022, desenvolvidos na América do Sul (16)(17)(18)(19) e América do Norte, (20)(21)(22)(23)(24)(25)(26)(27) Ásia, (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42) Europa, (43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53) África (54) e Oriente Médio. (55)(56)(57)(58) O país com maior número de publicações sobre LRA associada à COVID-19 foi a China, contemplando 27,3% (n = 12) dos artigos. (31)(32)(33)(34)(35)(36)…”

Section: Resultsunclassified

“…(55)(56)(57)(58) O país com maior número de publicações sobre LRA associada à COVID-19 foi a China, contemplando 27,3% (n = 12) dos artigos. (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42) Todos os estudos foram observacionais, com predomínio de coorte 63,6% (n=28), (16,17,20,21,23,28,29,(31)(32)(33)(35)(36)(37)(38)40,41,(43)(44)(45)(46)(51)(52)(53)(55)(56)(57)(58)(59) 77,3% (n = 34) retrospectivos (16)(17)(18)20,21,(24)...…”

Section: Resultsunclassified

“…O total de participantes incluídos nesta revisão compreendeu 78.467 pacientes, sendo a menor amostra entre os estudos individuais de 37 (30) pacientes e a maior de 41.294. (45) A mediana da idade foi maior que 36 anos para todos os estudos individuais e o sexo masculino foi predominante com 79,5% (n=35) (17,18,(20)(21)(22)(23)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)37,39,40,(42)(43)(44)(46)(47)(48)(49)(50)52,(54)(55)(56)(57)(58)(59)(60) (Quadro 2). O tempo médio de internação geral foi de 14,8 dias, variando entre 2 a 51 dias, sendo o tempo de internação maior em pacientes com LRA, de acordo com os estudos que apresentavam essa informação.…”

Section: Resultsunclassified

“…A ocorrência de Pereira AC, Almeida JC, Aguiar BR, Ferreira EB, Rocha PR LRA foi associada a maior frequência de mortalidade. (17,18,20,24,(28)(29)(30)(31)(32)(33)(34)(35)(36)38,40,42,43,46,(48)(49)(50)(51)(52)(54)(55)(56)58,59) A mortalidade por todas as causas variou de 1% (31,37) a 60%. (54,56) A mortalidade por LRA variou de 1% (28,31) a 43%.…”

Section: Resultsunclassified

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Lesão renal aguda em pacientes adultos com COVID-19: revisão integrativa

Pereira,

Almeida,

Aguiar

et al. 2024

Acta Paulista De Enfermagem

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intitulado "Fatores associados ao desenvolvimento da lesão renal aguda em pacientes adultos com COVID-19: revisão integrativa". ResumoObjetivo: Identificar a frequência de lesão renal aguda (LRA) em pacientes hospitalizados com COVID-19, as características associadas, a mortalidade e a letalidade.Métodos: Revisão realizada nas bases de dados CINAHL, Embase, LILACS, Livivo, PubMed, SCOPUS, Web of Science e, na literatura cinzenta (Google Acadêmico) em 12 de janeiro de 2022. Foram incluídos artigos em inglês, espanhol e português, publicados a partir de novembro 2019 até janeiro de 2022, em pacientes maiores de 18 anos com COVID-19 hospitalizados e LRA conforme critério Kidney Disease Improving Global Outcomes (KDIGO). Os estudos selecionados foram lidos na íntegra para extração, interpretação, síntese e categorização conforme nível de evidência.Resultados: 699 artigos encontrados e 45 incluídos. A idade avançada, sexo masculino, hipertensão, doença renal crônica, ventilação mecânica, aumento da proteína C reativa, uso de drogas vasoativas e de determinadas classes de anti-hipertensivos foram associados a LRA. A LRA está relacionada à maior frequência de mortalidade. Em 30% dos pacientes hospitalizados com COVID-19 houve LRA. A taxa de mortalidade por LRA foi de 5% e a letalidade de 18%.Conclusão: Estes resultados ressaltam a relevância da LRA como uma complicação significativa da COVID-19 e sugerem que um controle mais cuidadoso e precoce dos fatores associados poderia potencialmente reduzir a mortalidade e a letalidade. É crucial intensificar a pesquisa nesse campo para esclarecer melhor os mecanismos envolvidos na lesão renal em pacientes com COVID-19, bem como identificar estratégias terapêuticas mais efetivas para sua prevenção e tratamento nesse contexto.

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Lesão renal aguda em pacientes adultos com COVID-19: revisão integrativa

Pereira,

Almeida,

Aguiar

et al. 2024

Acta Paulista De Enfermagem

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“…The complication often occur along the course of COVID-19 hospitalization and is associated with increased illness severity, duration of stay, and poor prognosis [ 52 ]. Elkholi, et al found that AKI occurred in 65.1% of mechanically ventilated COVID-19 patients, and it was associated with significantly higher mortality [ 53 ]. Given that the data is from a registry and the study is retrospective, determining the cause-effect relationship is outside the scope of our study, and further studies are need to understand this aspect.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and outcomes of patients with severe COVID-19 in Indonesia: Lessons from the first wave

Burhan,

Liu,

Marwali

et al. 2023

PLoS ONE

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Background Indonesia’s national response to COVID-19 evolved rapidly throughout 2020. Understanding pandemic response and outcomes is crucial for better mitigation strategies ahead. This study describes the characteristics and outcomes of patients admitted to ICU during the early stages of the pandemic. Methods This is a multi-centre prospective observational study including patients from twelve collaborating hospitals in Indonesia. All patients were clinically suspected or laboratory-confirmed COVID-19 cases admitted to ICU between January 2020 and March 2021. The primary outcome was monthly ICU mortality. Descriptive statistics of patient characteristics and treatment were generated as secondary outcomes. Results From 559 subjects, the overall mortality was 68% and decreased over the study period, while the mortality of patients that received mechanical ventilation was 92%, consistently high over the study period. Fatal cases showed 2- and 4-day delays from symptoms onset to hospital admissions and ICU admissions, respectively. Evidence-backed approaches which could influence patient outcome, such as extracorporeal membrane oxygenation, prone positioning, renal replacement therapy, and neuromuscular blockade were scarcely administered. Conclusions The mortality rate of COVID-19 patients in Indonesia was extremely high during the first major outbreak of disease, particularly in those mechanically ventilated. Delayed admission and unavailability of evidence-based approaches due to high burden on health facility during COVID-19 crisis could be addressed by efficient public health measures and enhancing health infrastructure to improve the future pandemic response.

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Acute kidney injury in adult patients with COVID-19: an integrative review

Pereira,

Almeida,

Aguiar

et al. 2024

Acta Paul Enferm

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Objective: To identify the frequency of acute kidney injury (AKI) in patients hospitalized with COVID-19, associated characteristics, mortality and lethality. Methods: Integrative review carried out in the databases CINAHL, Embase, LILACS, Livivo, PubMed, SCOPUS, Web of Science and in the grey literature (Google Scholar) on January 12, 2022. Articles were included in English, Spanish and Portuguese, published from November 2019 to January 2022, in hospitalized patients over 18 years old with COVID-19 and AKI according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. The selected studies were read in full for extraction, interpretation, synthesis and categorization according to the level of evidence. Results: A total of 699 articles were found and 45 included. Older age, male gender, hypertension, chronic kidney disease, mechanical ventilation, increased C-reactive protein, use of vasoactive drugs and certain classes of antihypertensives were associated with AKI. AKI is related to a higher frequency of mortality. AKI occurred in 30% of patients hospitalized with COVID-19. The mortality rate from AKI was 5% and the case fatality rate was 18%. Conclusion: These results highlight the relevance of AKI as a significant complication of COVID-19 and suggest that more careful and early control of associated factors could potentially reduce mortality and lethality. It is crucial to intensify research in this field to better clarify the mechanisms involved in kidney injury in COVID-19 patients, as well as to identify more effective therapeutic strategies for its prevention and treatment in this context.

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Acute kidney injury in ventilated patients with coronavirus disease-2019 pneumonia: A single-center retrospective study

Cited by 3 publications

References 57 publications

Lesão renal aguda em pacientes adultos com COVID-19: revisão integrativa

Lesão renal aguda em pacientes adultos com COVID-19: revisão integrativa

Characteristics and outcomes of patients with severe COVID-19 in Indonesia: Lessons from the first wave

Acute kidney injury in adult patients with COVID-19: an integrative review

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