Acute Kidney Injury Following Dermatomyositis

Hamadeh, Majdi; Boustany, Sora; Fares, Jawad

doi:10.3121/cmr.2019.1487

Cited by 3 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism involved in JDM combined with renal injury may be multifactorial. Myoglobinuric rhabdomyolysis can cause acute tubular necrosis leading to acute kidney injury ( 12 ). In adults, acute kidney injury could occur in 16/150 inflammatory myopathy patients ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Juvenile dermatomyositis and nephrotic syndrome: A case report and a mini literature review

et al. 2023

View full text Add to dashboard Cite

BackgroundRenal involvement is rarely reported in juvenile dermatomyositis and may be caused by the toxic effects of myoglobinuria or an autoimmune reaction. We report a case of dermatomyositis and nephrotic syndrome in a child to explore the association between juvenile dermatomyositis and renal involvement.Case presentationAn 8-year-old girl with skin rash, edema, proximal muscle weakness predominantly involving the lower extremities, low-grade fever, and foamy urine was admitted to our hospital. Her laboratory tests met the criteria of nephrotic syndrome. She had elevated creatine kinase and lactate dehydrogenase and was diagnosed with juvenile dermatomyositis after electromyography and muscle MRI. Anti-NXP2 antibodies were positive. Her proteinuria was relieved soon after treatment with prednisone and methotrexate, but her muscle strength progressively decreased. The disease was relieved after pulse methylprednisolone treatment and mycophenolate mofetil, but recurred after drug reduction with mild proteinuria. Adalimumab was used for treatment and helped reduce the doses of glucocorticoid and mycophenolate mofetil.ConclusionJuvenile dermatomyositis may be one of the rare causes of nephrotic syndrome. The mechanism involved in JDM combined with renal injury may be multifactorial. Autoantibodies may play important roles in both muscle and renal damage.

show abstract

Section: Discussionmentioning

confidence: 99%

Juvenile dermatomyositis and nephrotic syndrome: A case report and a mini literature review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…It was previously considered that rhabdomyolysis leading to acute renal failure was uncommon in PM and DM because the rate and degree of myolysis could be lower than those of myotoxic drug-related necrotizing myopathy [11]. However, myoglobinuria-induced acute tubular necrosis caused by PM or DM has been reported in the literature, especially in patients with DM [12][13][14][15][16][17][18][19][20]. e other type of renal damage related to PM or DM is chronic glomerulonephritis, which is presumed to be immune-mediated, and exhibits a variety of histologic features.…”

Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature

Tsubouchi

Mizuuchi

Yamamoto

et al. 2022

Case Reports in Rheumatology

View full text Add to dashboard Cite

Renal involvement is underestimated as an extramuscular manifestation of dermatomyositis (DM). Here, we describe a 67-year-old woman with anti-glycyl-transfer ribonucleic acid synthetase (anti-EJ) antibody and anti-ribonucleoprotein antibody-positive DM complicated by systemic sclerosis, who developed nephrotic syndrome concurrently with the exacerbation of DM, as indicated by incremental serum creatine kinase levels, high-intensity lesions on muscle magnetic resonance imaging, and active interstitial pneumonitis on chest computed tomography. Renal biopsy revealed the presence of immune-deposition in the glomerulus by immunofluorescence. To our knowledge, this is the first report describing the coexistence of anti-EJ antibody-positive DM and nephrotic syndrome. More reports of similar cases are warranted to substantiate the association.

show abstract

“…Surveying the published data revealed a few cases reporting renal involvement in patients with DM and immunoglobulin A (IgA) nephropathy 4,6 . However, immunoglobulin M (IgM) nephropathy is yet to be reported.…”

Section: Introductionmentioning

confidence: 99%

“…Surveying the published data revealed a few cases reporting renal involvement in patients with DM and immunoglobulin A (IgA) nephropathy. 4,6 However, immunoglobulin M (IgM) nephropathy is yet to be reported. Here, we report the case of a 38-year-old man diagnosed with DM following coronavirus disease 2019 (COVID- 19) vaccination, complicated by IgM nephropathy.…”

mentioning

confidence: 99%

IgM nephropathy in a patient with dermatomyositis following COVID‐19 vaccination: A case report

et al. 2023

View full text Add to dashboard Cite

BackgroundDermatomyositis (DM) is a systemic autoimmune disease characterized by distinct skin lesions and a clinically heterogeneous constellation of systemic manifestations. This disease poses a challenge to clinicians because of its rarity, diverse clinical presentations, and variable organ involvement, resulting from an autoimmune attack on affected organs, which could be triggered by environmental factors in genetically susceptible individuals. Renal involvement is rare, with immunoglobulin M (IgM) nephropathy yet to be reported in patients with DM.Case presentationA 38‐year‐old man was admitted to Shariati Hospital, affiliated with Tehran University of Medical Sciences, with proximal weakness of the upper and lower extremities that had developed in the preceding month after receiving the Sinopharm COVID‐19 vaccine. The patient was diagnosed with DM based on the heliotrope rash, Gottron's papules, progressive proximal muscle weakness, and paraclinical findings. IgM nephropathy developed subsequently, diagnosed by light and immunofluorescence microscopy.ConclusionWe describe the first case of IgM nephropathy in a DM patient following COVID‐19 vaccination. This phenomenon requires further investigation into the possible crosslinks between the pathogenesis of IgM nephropathy with DM and the COVID‐19 vaccine. Diagnosing renal complications in DM patients promptly and accurately can help to achieve the best outcomes.

show abstract

Acute Kidney Injury Following Dermatomyositis

Cited by 3 publications

References 8 publications

Juvenile dermatomyositis and nephrotic syndrome: A case report and a mini literature review

Juvenile dermatomyositis and nephrotic syndrome: A case report and a mini literature review

Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature

IgM nephropathy in a patient with dermatomyositis following COVID‐19 vaccination: A case report

Contact Info

Product

Resources

About