Acute Kidney Injury Due to Collapsing Glomerulopathy Following COVID-19 Infection

Peleg, Yonatan; Kudose, Satoru; Siddall, Eric; Ahmad, Syeda Behjat; Nickolas, Thomas L.; Kisselev, Sergey; Gharavi, Ali G.; Canetta, Pietro A.

doi:10.1016/j.ekir.2020.04.017

Cited by 206 publications

(245 citation statements)

References 9 publications

(13 reference statements)

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“…Although our understanding is incomplete, a picture is emerging from case reports and autopsy series of covid-19 specific causes of AKI. Intrinsic renal pathology including thrombotic vascular processes, viral mediated tubular cell injury, and glomerulonephritis have been reported, as well as AKI resulting from extrinsic factors such as fluid depletion, multi-organ failure, and rhabdomyolysis 34567. Anecdotal reports have emerged of proximal tubular injury with Fanconi syndrome that manifests as hypokalaemia, hypophosphataemia, normal anion gap metabolic acidosis, and hypovolaemia from salt wasting.…”

mentioning

confidence: 99%

Covid-19 and acute kidney injury in hospital: summary of NICE guidelines

Selby

Forni

Laing

et al. 2020

BMJ

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confidence: 99%

Covid-19 and acute kidney injury in hospital: summary of NICE guidelines

Selby

Forni

Laing

et al. 2020

BMJ

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“…Viral infections may exacerbate glomerular disease, such as immune-complex-mediated glomerulopathies related to HCV infection and collapsing glomerulopathy (CG) related to HIV infection (18). Importantly, recent studies show that African American patients with COVID-19 who carried the APOL1 gene risk variant developed CG, which raise the possibility that COVID-19 can induce glomerular disease (19,20). To date, these morphological changes have not been reported in Chinese patients.…”

Section: Resultsmentioning

confidence: 99%

Clinical and pathological findings of SARS-CoV-2 infection and concurrent IgA nephropathy: A case report

Liu

2020

Preprint

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Background: Since the Coronavirus Disease 2019 (COVID-19) outbreak, there is limited data on the clinical characteristics, treatment strategies and prognosis of COVID-19 in patients with concurrent renal disease. The kidney is believed to have a predisposition for COVID-19 due to its abundant angiotensin-converting enzyme 2 (ACE2) expression, which acts as a cell entry receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Recent postmortem investigations reveal renal involvement in COVID-19, and case reports describe collapsing glomerulopathy in African American patients with COVID-19. However, there is limited data regarding IgA nephropathy in the setting of COVID-19.Case presentation: In the present case, we report a 65-year old Chinese woman who presented with macroscopic hematuria, worsening proteinuria and decreased renal function after COVID-19 infection. She received a renal biopsy during COVID-19 infection. The renal biopsy revealed IgA nephropathy without any evidence for SARS-Cov-2. The findings suggest that the renal abnormalities were a consequence of exacerbation of this patient’s underlying glomerular disease after COVID-19 infection. After a regimen of 3-day course of glucocorticoid and angiotensin II receptor blocker therapy, the patient recovered and remained stable upon follow-up. Conclusions: It is important to consider the underlying glomerular disease exacerbation rather than virus induced injury when dealing with renal abnormalities in patients with COVID-19.

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“…On the other hand, the patient developed an episode of Acute Kidney Injury (AKI) and severe proteinuria, which had been controlled before. Recently, Larsen et al (9) and Peleg et al (10) reported cases of AKI in COVID-19. Besides, the Mathian et al (3) study reported that 18% of SLE individuals who tested positive for COVID-19 developed AKI.…”

Section: Discussionmentioning

confidence: 99%

A Flare of Lupus Nephritis in an 11-Year-Old SLE Patient with a Mild COVID-19-Associated Pneumonia

et al. 2020

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: Children with immunological diseases like SLE are vulnerable to any type of infection, and their management is considered an important issue in the COVID-19 pandemic. Here, we describe an 11-year-old female, previously known to have lupus nephritis, complaining of tachypnea, persistent fever, low oxygen saturation (SaO2), and generalized edema with confirmed COVID-19 using sputum PCR testing on the first day of admission.

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Acute Kidney Injury Due to Collapsing Glomerulopathy Following COVID-19 Infection

Cited by 206 publications

References 9 publications

Covid-19 and acute kidney injury in hospital: summary of NICE guidelines

Covid-19 and acute kidney injury in hospital: summary of NICE guidelines

Clinical and pathological findings of SARS-CoV-2 infection and concurrent IgA nephropathy: A case report

A Flare of Lupus Nephritis in an 11-Year-Old SLE Patient with a Mild COVID-19-Associated Pneumonia

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