Acute kidney injury and tubular biomarkers after hematopoietic stem cell transplantation

THE AIM.To determine clinical value of acute kidney injury (AKI) in the setting of allogeneic hematopoietic stem cell transplantation (HSCT) for mortality along postransplant period.PATIENTS ANDMETHODS.Ninety hematopoietic stem cell transplantat (HSCT) recipients (46 males, 44 females) were enrolled in the observational prospective study. Clinical and laboratory data were monitored and assessed 7 days prior to HSCT (week 0), on the posttransplant weeks 1, 2, 3, 4 and 5. AKI was diagnosed according to KDIGO (Kidney Disease Improving Global Outcomes) guidelines. All-cause mortality was registered along 1 year of posttransplant period. AKI associations with death risk were estimated in cumulative survival analysis and Cox multivariate regression models adjusted for other confounders.RESULTS.AKI was diagnosed in 67 (74%) out of 90 patients. The majority of patients (84%) suffered from AKI 1 stage (KDIGO). AKI 2+3 stage (KDIGO) was found in 16% of patients. Renal replacement therapy was used in 4 (6%) patients with AKI. Cumulative survival rate following HSCT reached 75%. 28 deaths (31%) were registered within 1 year following HSCT. AKI was associated with lower cumulative survival following HSCT. AKI was independently associated with the risk of death according to multivariate Cox regression analyses adjusted for other confounders.CONCLUSION. AKI may be considered as a significant clinical predictor of unfavorable allogeneic HSCT outcome, taking into account its independent association with increased risk of posttransplant all-cause mortality.

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Acute Kidney Injury Is Independently Associated With All-Cause Mortality Following Hematopoietic Stem Cell Transplantation

Smirnov

Добронравов

Afanasiev

et al. 2018

Nefrologiâ (St.-Peterbg.)

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Nephrology: fundamental and clinical

Смирнов¹,

Natochin

2019

Nefrologiâ (St.-Peterbg.)

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Лаборатория физиологии почки, Институт эволюционной физиологии и биохимии им. И.М. Сеченова Российской академии наук, Санкт-Петербург, Россия, 2 Научно-исследовательский институт нефрологии, кафедра пропедевтики внутренних болезней с клиникой, Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, Санкт-Петербург, Россия РЕФЕРАТ В настоящее время фундаментальная нефрология включает в себя многие разделы смежных наук, дающих новый импульс к пониманию механизмов функционирования почки на молекулярном уровне. Авторы статьи подчеркивают, что в основе функций почек лежат молекулярные системы, включающие разнообразные рецепторы, котранспортеры, насосы и ионные каналы, которые в конечном итоге обеспечивают гомеостаз организма. Фундаментальная нефрология, представляющая собой синтез физиологии и молекулярных ОМИКС-исследований, позволяет врачу более глубоко вникать в сущность патологических процессов, проводить диагностику болезней почек на доклиническом уровне. Тесная взаимосвязь фундаментальной и клинической нефрологии обеспечивает не только трансляцию научных достижений в практику, но и способствует персонификации терапии. Ключевые слова: фундаментальная нефрология, клиническая нефрология, патологический процесс, молекулярные ОМИКС-исследования, терапия

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Immunological features of out-of-hospital pneumonia in children vaccinated with pneumococcal vaccine

Tukbekova,

Zhanpeissova,

Kizatova

et al. 2023

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Аim. To identify the immunological features of out-of-hospital pneumonia in vaccinated children, to assess their impact on the severity of the disease.Materials and methods. The study was conducted in 2017-2019. 85 children with various degrees of severity were hospitalized in Karaganda from 2 months to 3 years. They were divided into 2 groups: the first included vaccinated children (n=45), the second included children with impaired vaccination (n=40). The control group consisted of 20 children.The calculation and evaluation of the results obtained was carried out on an IBM compatible computer with the Windows XP operating system using the MS Excel 2017 (Microsoft), SPSS 12.0.2 and Statistica 20 software package. Statistical analysis was carried out using the STATISTICA package. Numerical data is represented by indicators such as Me (median), Q1 (L-quartile or lower quartile point) and Q3 (U-quartile or upper quartile point). Kruskall-Wallace criterion calculated [Kruskall W., Walles W. A.]. The differences were considered statistically significant at p < 0.05.Results and discussion. The quantitative indicator of anti-inflammatory MCP-1 cytokines in vaccinated children with severe nosocomial pneumonia in early childhood is 7.21 [5.25; 9.03] pg/ml Me [Q1; Q3], and in children with immunization disorders-15.18 [6.13; 50.11] pg/ml Me [Q1; Q3] (Kruskal criteria-Wallis p<0.05). In children aged 2 months to 3 years, the quantitative indicator of anti-inflammatory cytokines MCP-1 in vaccinated children with mild nosocomial pneumonia is 2.13 [0.01; 3.02] pg/ml Me [Q1; Q3], and in children with immunization disorders –3.46 [0.04; 6.74] pg/ml Me [Q1; Q3].

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Acute kidney injury and tubular biomarkers after hematopoietic stem cell transplantation

Cited by 3 publications

References 20 publications

Acute Kidney Injury Is Independently Associated With All-Cause Mortality Following Hematopoietic Stem Cell Transplantation

Acute Kidney Injury Is Independently Associated With All-Cause Mortality Following Hematopoietic Stem Cell Transplantation

Nephrology: fundamental and clinical

Immunological features of out-of-hospital pneumonia in children vaccinated with pneumococcal vaccine

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