Acute Kidney Injury After Radical Cystectomy for Bladder Cancer is Associated with Chronic Kidney Disease and Mortality

Kwon, Taekmin; Jeong, In Gab; Lee, Chunwoo; You, Dalsan; Hong, Bumsik; Hong, Jun Hyuk; Ahn, Hanjong; Kim, Choung‐Soo

doi:10.1245/s10434-015-4886-4

Cited by 22 publications

(16 citation statements)

References 31 publications

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“…Besides, partial or radical cystectomy are standard surgical procedure for patients with bladder cancer. A cohort study, including 886 patients who underwent radical cystectomy for bladder cancer, found that 33.1% developed AKI in the first week after surgery . All of these factors contributed to the high incidence of AKI in patients with bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

“…A cohort study, including 886 patients who underwent radical cystectomy for bladder cancer, found that 33.1% developed AKI in the first week after surgery. 15 All of these factors contributed to the high incidence of AKI in patients with bladder cancer. The development of AKI is also common in patients with leukemia and lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…Up to now, high quality epidemiological data on the spectrum of AKI in cancer patients from the developing world, including most Asian countries, are particularly scarce. Previous large studies about AKI in cancer patients were restricted to western countries, critically ill patients or select group of cancer patients . Additionally, some of these studies used the RIFLE (Risk, Injury, Failure, Loss, and ESRD) criteria to identify and classify AKI .…”

Section: Introductionmentioning

confidence: 99%

“…Previous large studies about AKI in cancer patients were restricted to western countries, 9,10 critically ill patients [11][12][13] or select group of cancer patients. [13][14][15][16][17] Additionally, some of these studies used the RIFLE (Risk, Injury, Failure, Loss, and ESRD) criteria to identify and classify AKI. 9,10 In 2012, the Kidney Disease Improving Global Outcomes (KDIGO) Work Group proposed a consensus-based AKI defining and staging system, 18 which has been adopted in many countries.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology and outcomes of acute kidney injury in hospitalized cancer patients in China

Cheng

Nie

et al. 2019

Intl Journal of Cancer

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Acute kidney injury (AKI) is a common complication in cancer patients, but the data are lacking in Asian countries. We aimed to assed the epidemiology, correlated risk factors and outcomes of AKI in cancer patients from China. We conducted a nationwide cohort study of cancer patients who were admitted to 25 general and children hospitals across China from January 1, 2013 to December 31, 2015. We obtained patient‐level data from the electronic hospitalization information system and laboratory databases of all inpatients who had at least two serum creatinine tests within any 7‐day window during their first 30 days of hospitalization. AKI was defined and staged according to Kidney Disease Improving Global Outcomes criteria. Incidence rate and risk factor profiles for AKI were examined. Outcomes of interest included in‐hospital mortality, length of stay and daily costs. A total of 136,756 adult cancer patients were assessed in our study. The overall incidence of AKI was 7.5%, of which 1.6% were community acquired and 5.9% hospital acquired. The top three cancer types with high incidence of AKI were bladder cancer, leukemia, and lymphoma. Risk factors for community‐acquired and hospital‐acquired AKI were similar, including age, increased baseline serum creatinine, shock and urinary tract obstruction. In‐hospital death occurred in 12.0% with AKI vs. 0.9% cancer patients without AKI. After adjustment for confounders, the severe AKI was associated with higher risk of in‐hospital death, prolonged length of stay and higher daily costs. Clinicians should increase their awareness of AKI in hospitalized cancer patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epidemiology and outcomes of acute kidney injury in hospitalized cancer patients in China

Cheng

Nie

et al. 2019

Intl Journal of Cancer

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“…Several studies have highlighted the role of AKI on mortality in patients with hematologic malignancies receiving induction therapy, diffuse large B‐cell lymphoma, gastric cancer, bladder cancer, and lung cancer . Additionally, the increase in mortality according to the development of AKI has not been observed in all studies due to the different patients' conditions, including overall severity, and functional status …”

Section: Introductionmentioning

confidence: 99%

Acute kidney injury predicts all‐cause mortality in patients with cancer

Kang

Park

et al. 2019

Cancer Medicine

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Background Acute kidney injury (AKI) is a critical issue in cancer patients because it is not only a morbid complication but also able to interrupt timely diagnostic evaluation or planned optimal treatment. However, the impact of AKI on overall mortality in cancer patients remains unclear. Methods We conducted a retrospective cohort study of 67 986 cancer patients, from 2004 to 2013 to evaluate the relationship between AKI and all‐cause mortality. We used KDIGO AKI definition and grading system. Results During 3.9 ± 3.1 years of follow‐up, 33.8% of the patients experienced AKI at least once. Among AKI events, stage 1, 2, and 3 was 71.0%, 13.8%, and 15.1%, respectively. AKI incidence was highest in hematologic malignancies, followed by urinary tract cancer, and hepatocellular carcinoma. Male sex, older age, underlying diabetes and hypertension, lower serum albumin and plasma hemoglobin, more frequent radio‐contrast exposure, entrance of clinical trials, and receiving chemotherapy were associated with AKI occurrence. AKI development was an independent risk factor for elevated mortality in cancer patients with dose‐responsive manner (Stage 1, hazard ratio [HR] 1.183, 95% confidence interval [CI] 1.145‐1.221, P < 0.001; Stage 2, HR 1.710, 95% CI 1.629‐1.796; Stage 3, HR 2.000, 95% CI 1.910‐2.095; No AKI, reference group) even after adjustment. This tendency was reproduced in various cancer types except thyroid cancer and in various treatment modalities, however, not shown in patients with baseline renal dysfunction. Conclusion AKI was an independent risk factor for all‐cause mortality in overall cancer patients with dose‐responsive manner.

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