Acute Kidney Injury After On-Pump or Off-Pump Coronary Artery Bypass Grafting in Elderly Patients

Incidence and impact of acute kidney injury in patients with acute coronary syndromes treated with coronary artery bypass grafting: Insights from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) and Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trials

“…18,19 Furthermore, the risk is increased with the use of cardiopulmonary bypass due to non-pulsatile blood flow leading to renal hypoperfusion as well as hypothermia. [20][21][22] Our study demonstrated a higher than predicted incidence of AKI associated with CABG. 21,23,24 Previous data have quoted the incidence of AKI following CABG as low as 7%, 22 while others have indicated AKI occurs at a frequency of 30%, in keeping with our findings.…”

“…AKI can affect anywhere from 5% to 30% of patients undergoing cardiac surgery, 7-10 with an increased risk associated with cardiopulmonary bypass. 11,12 The development of AKI in the setting of cardiac surgery is an independent predictor of inhospital and long-term mortality, as well as prolonged length of stay both in the hospital and intensive care unit. 8,13 In patients undergoing CABG, the risk of developing AKI is further compounded by exposure to iodinated contrast from the diagnostic coronary angiography.…”

TIMP-2*IGFBP7 (Nephrocheck®) Measurements at Intensive Care Unit Admission After Cardiac Surgery are Predictive for Acute Kidney Injury Within 48 Hours

“…Measurement of [TIMP-2*IGFBP7] before surgery was not helpful to predict AKI, neither alone nor in combination with [TIMP-2*IGFBP7] values at ICU admission. AKI is a common complication after cardiac surgery with an incidence between 20-50% in patients undergoing cardiac surgery [2, 3, 22-25]. Stage I of AKI according to most recent guidelines is defined as a rise in SCr of ≥0.3mg/dl within 48 hours.…”

The Incidence of Acute Kidney Injury after Coronary Artery Bypass Surgery with or without Cardiopulmonary Bypass

“…So, some studies believe that the CPB is a risk factor for AKI and the elimination of CPB reduces the inflammation and AKI (4,9). Studies have demonstrated that the incidence of AKI is higher in the on-pump group (10,11), but others have reported no difference between the AKI in the on-pump and the off-pump patients (3). Based on the available data the need for more research in the field of AKI is inevitable (12).…”

“…Based on different definitions of acute renal failure, the incidence of ARF after CABG varies from 6.9% to 42.5% (1,2). Some studies have reported AKI in half of the cardiac surgical patients (3). Age, hypertension, NYHA class, diabetes, cardiopulmonary bypass time, redo operation, ejection fraction, and the haematocrit level are considered as some risk factors of AKI (4,5).…”