Acute increase in plasma D-dimer level in ovarian torsion: an experimental study

Kart, Cavit; Aran, Turhan; Güven, Süleyman; Karahan, Süleyman Caner; Yuluğ, Esin

doi:10.1093/humrep/deq378

Cited by 29 publications

(22 citation statements)

References 11 publications

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“…Serum D-dimer, ischemia-modified albumin, IL-6, IL-8, TNF-a, and E-selectin, have been investigated as serum markers in patients with ovarian torsion. Among these, elevated IL-6, D-dimer, and ischemia-modified albumin concentrations have been shown to be associated with ovarian torsion [2,[11][12][13][14][15]. Kart et al investigated the diagnostic value of plasma D-dimer level in an experimental rat ovarian torsion model and stated that D-dimer was well correlated with histopathological damage scores of ovarian injury and might be used as a plasma marker in early detection of ovarian torsion [14].…”

Section: Discussionmentioning

confidence: 99%

“…Among these, elevated IL-6, D-dimer, and ischemia-modified albumin concentrations have been shown to be associated with ovarian torsion [2,[11][12][13][14][15]. Kart et al investigated the diagnostic value of plasma D-dimer level in an experimental rat ovarian torsion model and stated that D-dimer was well correlated with histopathological damage scores of ovarian injury and might be used as a plasma marker in early detection of ovarian torsion [14]. Aran et al studied ischemia-modified albumin levels in a rat model and concluded that it was a useful adjunct that could be used in the diagnosis of ovarian torsion and also stated that ischemia-modified albumin levels were correlated with the semiquantitative histologic scores of the specimens [15].…”

Section: Discussionmentioning

confidence: 99%

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High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study

Bakacak

Köstü

Ercan

et al. 2014

Arch Gynecol Obstet

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study

Bakacak

Köstü

Ercan

et al. 2014

Arch Gynecol Obstet

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“…The detorsion group had the highest score for four ovarian injury parameters. Previous studies using a cellular scoring system have reported more ovarian damage after detorsion than due to the torsion [24,25]. Ischemia, which causes insufficient blood flow and insufficient oxygen support, leads to a decrease in the production of ATP, an increase in the production of lactic acid, and the accumulation of lipid peroxidase in tissue [5].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Protective Effects of CoQ<sub>10</sub> on Ovarian I/R Injury: An Experimental Study

Özler

Turgut

Görük

et al. 2013

Gynecol Obstet Invest

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Background: The aim of this study was to investigate the protective effects of coenzyme Q₁₀ (CoQ₁₀) on ovarian ischemia/reperfusion injury in an experimental rat adnexal torsion model. Methods: 48 female adult Wistar albino rats, weighing 220-250 g, were randomly equally divided into six groups (n = 8): sham, torsion, detorsion, sham+CoQ₁₀, torsion+CoQ₁₀, and detorsion+CoQ₁₀ groups. Bilateral adnexal torsion was performed for 3 h in all groups, except the sham and sham+CoQ₁₀ groups. Bilateral adnexal detorsion was performed on the detorsion and detorsion+CoQ₁₀ groups. CoQ₁₀ was injected intraperitoneally 30 min before the sham operation, torsion, and detorsion. Results: The torsion and detorsion groups had significantly higher histologic evaluation scores, as well as higher MDA levels, TOS values, and oxidative stress index values than the sham group. A strong correlation between total histologic evaluation scores for ischemia/reperfusion injury and the oxidative stress index was found. The mean oxidant marker levels and histopathologic scores for the ovarian tissue significantly decreased after using CoQ₁₀, which is a potent antioxidant. Conclusions: Conservative surgery (detorsion) was found to provide inadequate protection to ovarian tissue. The results of this study suggest that CoQ₁₀ could be useful for the protection of ovarian tissue before conservative surgery.

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“…The only serum marker test studied in human subjects is interleukin (IL)-6, which was found to be elevated in ovarian torsion [3]. In our previous experimental studies (in animals), we also showed that serum ischemia-modified albumin (IMA) and D -dimer may be used in the early diagnosis of ovarian torsion [4,5]. Since these studies were experimental, the role of IMA in the diagnosis of ovarian torsion in humans and the threshold value of IMA have not been known or previously reported.…”

Section: Introductionmentioning

confidence: 99%

Is the Measurement of Serum Ischemia-Modified Albumin the Best Test to Diagnose Ovarian Torsion?

Güven

Kart²,

Güven³

et al. 2015

Gynecol Obstet Invest

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Aim: The aim of this study is to evaluate the diagnostic value of serum oxidative stress marker levels (ischemia-modified albumin, IMA; malondialdehyde, MDA) and total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) levels that occur in ovarian torsion and to determine the threshold value of these markers in the diagnosis of ovarian torsion. Methods: In this prospective case-control study, 34 women (the study group) with acute pelvic pain (20 with and 14 without ovarian torsion) and 40 control subjects were included. The diagnosis of ovarian torsion was confirmed with laparoscopy in all cases. Preoperative serum samples were collected in the study group. Serum oxidative stress marker levels (IMA and MDA) and TOS, TAS and OSI levels were measured. Results: Serum MDA, TOS and IMA concentrations were significantly higher in women with ovarian torsion than in the healthy control group. However, serum TAS, TOS and OSI concentrations were significantly higher in women without ovarian torsion than within the healthy control group. Only IMA significantly distinguished patients with or without ovarian torsion. The best IMA value, according to the receiver operating characteristic curve, was 0.7045 absorbance units, with 90.00% sensitivity and 92.31% specificity. The patients in the ovarian torsion group had significantly lower serum TAS and OSI levels compared with patients without ovarian torsion. Conclusion: The elevated serum IMA levels with high sensitivity-specificity values observed in women with ovarian torsion seem to have a potential role as a serum marker in the preoperative diagnosis of ovarian torsion in emergency settings.

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Acute increase in plasma D-dimer level in ovarian torsion: an experimental study

Abstract: If the observations made in a rat model are extended to humans, plasma D-dimer measurement may be a valuable parameter in the early diagnosis of ovarian torsion.

Cited by 29 publications

References 11 publications

High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study

High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study

Evaluation of the Protective Effects of CoQ<sub>10</sub> on Ovarian I/R Injury: An Experimental Study

Is the Measurement of Serum Ischemia-Modified Albumin the Best Test to Diagnose Ovarian Torsion?

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