Acute Hemolytic Transfusion Reactions

Bellone, Michael; Hillyer, Christopher D.

doi:10.1016/b978-0-12-397164-7.00061-6

Cited by 3 publications

(8 citation statements)

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“…Anemia in the setting of hyperproliferative reticulocytosis (15.3%; normal 0.5%-1.5%), up-trending LDH, indirect bilirubin, and an undetectable haptoglobin, is consistent with a diagnosis of hemolytic anemia, the lysis of red blood cells. 3 Even more specifically, the elevated indirect bilirubin and low haptoglobin indicated intravascular hemolysis. 3…”

Section: Given This Presentation and Constellation Of Laboratory Findmentioning

confidence: 99%

“…3 Even more specifically, the elevated indirect bilirubin and low haptoglobin indicated intravascular hemolysis. 3…”

Section: Given This Presentation and Constellation Of Laboratory Findmentioning

confidence: 99%

“…(AHTRs), delayed hemolytic transfusion reactions (DHTRs), and hemolytic anemia secondary to transfusion-transmitted infection (TTI). [3][4][5] Acute hemolytic transfusion reactions can range from mild to life-threatening and occur within 24 hours of transfusion. 3 Acute hemolytic transfusion reactions are caused by the activation of the complement cascade in the presence of antigen: antibody complexes, leading to intravascular hemolysis.…”

Section: What Are Causes Of Hemolytic Anemia In Patients Who Have Recmentioning

confidence: 99%

“…[3][4][5] Acute hemolytic transfusion reactions can range from mild to life-threatening and occur within 24 hours of transfusion. 3 Acute hemolytic transfusion reactions are caused by the activation of the complement cascade in the presence of antigen: antibody complexes, leading to intravascular hemolysis. 3 Transfusion of ABO-incompatible PRBCs causes most AHTRs, estimated to occur in 1:38 000 to 1:100 000 transfusions.…”

Section: What Are Causes Of Hemolytic Anemia In Patients Who Have Recmentioning

confidence: 99%

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Educational Case: A Case of Transfusion-Transmitted Babesiosis: Diagnostic Perspectives Across the Clinical Laboratory

Dykes

Peedin

2020

Academic Pathology

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The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040 .1

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Section: Given This Presentation and Constellation Of Laboratory Findmentioning

confidence: 99%

“…3 Even more specifically, the elevated indirect bilirubin and low haptoglobin indicated intravascular hemolysis. 3…”

Section: Given This Presentation and Constellation Of Laboratory Findmentioning

confidence: 99%

Section: What Are Causes Of Hemolytic Anemia In Patients Who Have Recmentioning

confidence: 99%

Section: What Are Causes Of Hemolytic Anemia In Patients Who Have Recmentioning

confidence: 99%

See 2 more Smart Citations

Educational Case: A Case of Transfusion-Transmitted Babesiosis: Diagnostic Perspectives Across the Clinical Laboratory

Dykes

Peedin

2020

Academic Pathology

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show abstract

“…Cada antígeno possui determinado grau de imunogenicidade, e, portanto, devem ser respeitados para evitar complicações como, por exemplo, a aloimunização, isto é, a formação de novos anticorpos devido à exposição a antígenos não próprios (BAIOCHI;NARDOZZA, 2009). Outra preocupação dos profissionais da saúde antes e depois da realização de uma transfusão são as reações hemolíticas agudas e tardias causadas pela ativação do sistema complemento e consequente hemólise no paciente (BELLONE;HILLYER, 2013;DASARARAJU;MARQUES, 2015;STOWELL et al, 2012) Por este motivo, de modo a se evitar a aloimunização eritrocitária na prática Kidd (Jk a ) e MNS (S), a redução seria de 90% (SCHONEWILLE, 2008). No entanto, em algumas situações de emergência, principalmente traumas, não são realizados os testes imuno-hematológicos completos necessários para verificação da compatibilidade fenotípica dos grupos sanguíneos.…”

Section: Antígenos Eritrocitários E Aloimunizaçãounclassified