We read the article of Sağ et al.(1) about the hemodialysisinduced modifications of the left ventricular diastolic dysfunction parameters with great interest. The study of patients before and after hemodialysis is a valuable tool in determining the load dependency of different echocardiographic parameters. However, studies in this field have produced variable results.We have studied 26 adult patients (21 men, mean age 43±12 years) with end-stage renal disease and without previous known heart disease who underwent echocardiography before and after hemodialysis sessions over the course of one year, with a mean fluid removal of 1830±580 mL/session. Regarding the parameters of diastolic dysfunction studied, we did not find a significant difference in the pre-and post-hemodialysis ratio between the early diastolic mitral annulus velocity (Em) and the late atrial mitral annulus velocity (Am), measured by tissue Doppler and averaged for the septal, lateral, anterior and posterior annulus. Moreover, observing the pulsed Doppler pulmonary vein flow, the velocity of the systolic (S) wave and the ratio between the systolic and diastolic (D) waves did not change significantly after hemodialysis, although some variability was observed in the velocity of the D wave. This finding differs from the study of Sağ et al. (1); the results are presented in Table 1.Controversial data exist about the volume load influence of diastolic dysfunction parameters. Drighil et al. (2) found the tissue Doppler Em/Am ratio to be load-dependent, but only after large fluid volume reductions following hemodialysis, and did not find any preload-independent parameters. The study of Abid et al. (3) found the pulmonary vein flow systolic velocity and also the diastolic intraventricular flow propagation velocity to be load-independent parameters. We must note that most of the studies in the field suffer from a small population size and, perhaps more importantly, vary greatly in fluid quantity loss by hemodialysis, which is a variable that significantly influences the echocardiographic measurements.Further investigation of these parameters is warranted, given the fact that diastolic dysfunction is a predictor of mortality, especially in chronic kidney disease patients (4). In this regard, a larger study or perhaps a meta-analysis could provide better understanding of the subject.