Acute Glomerulonephritis and Encephalomyelitis following Group G Streptococcal Bacteremia

Manian, Farrin A.; Chor, Paula J.; Weaver, Mark E.; Logan, W. R.

doi:10.1093/clinids/14.3.784-a

Cited by 4 publications

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“…1 Although there may be a question of MS in this child, the young age, occurrence in setting of fever, transverse myelitis with areflexia, and occurrence of widespread multifocal central nervous lesions mostly located at the gray-white matter junction all favor ADEM. With the exception of Streptococcus pneumoniae (which has been related to outbreaks of suppurative meningitis and meningoencephalitis) and meningoencephalitis after exposure to group G Streptococci, 23,24 streptococcal infections of the human CNS after contact with other streptococci, in casu S. pyogenes (group A Streptococcus), are sporadic. With the exception of Streptococcus pneumoniae (which has been related to outbreaks of suppurative meningitis and meningoencephalitis) and meningoencephalitis after exposure to group G Streptococci, 23,24 streptococcal infections of the human CNS after contact with other streptococci, in casu S. pyogenes (group A Streptococcus), are sporadic.…”

Section: Discussionmentioning

confidence: 99%

Encephalomyelitis-associated antimyelin autoreactivity induced by streptococcal exotoxins

Jorens¹,

VanderBorght²,

Ceulemans³

et al. 2000

Neurology

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Section: Discussionmentioning

confidence: 99%

Encephalomyelitis-associated antimyelin autoreactivity induced by streptococcal exotoxins

Jorens¹,

VanderBorght²,

Ceulemans³

et al. 2000

Neurology

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“…Important human GGS mainly include Streptococcus dysgalactiae subspecies equisimilis (SDSE) and S. anginosus group ( S. anginosus , S. constellatus , and S. intestinalis ) . SDSE is the most dominant human GGS species which causes a broad spectrum of diseases including pharyngitis , necrotizing cellulitis , bacteremia , acute rheumatic fever , acute glomerulonephritis , and streptococcal toxic shock syndrome .…”

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confidence: 99%

Distribution of virulence factors and association with emm polymorphism or isolation site among beta‐hemolytic group G Streptococcus dysgalactiae subspecies equisimilis

Cheng

2014

APMIS

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Distribution of virulence factors and association with emm polymorphism or isolation site among beta-hemolytic group G Streptococcus dysgalactiae subspecies equisimilis. Streptococcus dysgalactiae subspecies equisimilis (SDSE), the dominant human pathogenic species among group G streptococci, is the causative agent of several invasive and non-invasive diseases worldwide. However, limited information is available about the distribution of virulence factors among SDSE isolates, or their association with emm types and the isolation sites. In this study, 246 beta-hemolytic group G SDSE isolates collected in central Taiwan between February 2007 and August 2011 were under investigation. Of these, 66 isolates were obtained from normally sterile sites and 180 from non-sterile sites. emm typing revealed 32 types, with the most prevalent one being stG10.0 (39.8%), followed by stG245.0 (15.4%), stG840.0 (12.2%), stG6.1 (7.7%), and stG652.0 (4.1%). The virulence genes lmb (encoding laminin-binding protein), gapC (glyceraldehyde 3-phosphate dehydrogenase), sagA (streptolysin S), and hylB (hyaluronidase) existed in all isolates. Also, 99.2% of the isolates possessed slo (streptolysin O) and scpA (C5a peptidase) genes. In addition, 72.8%, 14.6%, 9.4%, and 2.4% of the isolates possessed the genes ska (streptokinase), cbp (putative collagen-binding protein, SDEG_1781), fbp (putative fibronectin-binding protein, SDEG_0161), and sicG (streptococcal inhibitor of complement), respectively. The only superantigen gene detected was spegg (streptococcus pyrogenic exotoxin G(dys) ), which was possessed by 74.4% of the isolates; these isolates correlated with non-sterile sites. Positive correlations were observed between the following emm types and virulence genes: stG10.0 and stG840.0 with spegg, stG6.1 and stG652.0 with ska, and stG840.0 with cbp. On the other hand, negative correlations were observed between the following: stG245.0, stG6.1, and stG652.0 types with spegg, stG10.0 with ska, and stG10.0, stG245.0, and stG6.1 types with cbp. The prevalence of emm types of SDSE in central Taiwan was investigated for the first time. Moreover, the distribution of virulence factors among beta-hemolytic group G SDSE isolates, as well as their association with emm types or isolation sites were also examined.

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Comparative Studies on Streptococci of Serological Group G Isolated from Various Origins

Indarjulianto

Lämmler

1996

Journal of Veterinary Medicine, Series B

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Summary The streptococcal cultures used in the present study were isolated from dogs, bovines and humans and could be classified into Lancefield's serological group G. Most of the group G streptococci grew in fluid media as granular sediment with clear supernatant and formed compact colonies in soft agar. The majority of the group G streptococci from dogs and bovines displayed CAMP‐like synergistic haemolytic activities on sheep blood agar, fermented lactose and salicin and produced the enzyme α‐D‐galactosidase. The group G streptococci from humans mainly fermented trehalose and produced the enzyme β‐D‐glucuronidase. In addition, some of the group G streptococci reacted with type antigen X and R and two cultures with M6 specific antiserum. A positive opacity factor reaction could be observed with few group G streptococci isolated from dogs and bovines, but not with those from humans. In binding studies with 125I‐labelled plasma proteins most of the cultures interacted with 125I‐immunoglobulin G and 125I‐albumin. Binding of 125I‐IgG was more pronounced among group G streptococci isolated from humans. The determination of antibiotic susceptibility revealed that most of the group G streptococci were susceptible to bacitracin, cefoxitin, clindamycin, erythromycin, gentamicin, penicillin and sulfamethoxazole‐trimethoprim. Some of the cultures were resistant to minocycline, neomycin and tetracycline. All this data clearly distinguished group G streptococci isolated from animals and humans and could additionally be used for individual characterization of this microorganism. This might be useful in epidemiological aspects and contribute to understanding infections caused by these bacteria.

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Acute Glomerulonephritis and Encephalomyelitis following Group G Streptococcal Bacteremia

Cited by 4 publications

References 0 publications

Encephalomyelitis-associated antimyelin autoreactivity induced by streptococcal exotoxins

Encephalomyelitis-associated antimyelin autoreactivity induced by streptococcal exotoxins

Distribution of virulence factors and association with emm polymorphism or isolation site among beta‐hemolytic group G Streptococcus dysgalactiae subspecies equisimilis

Comparative Studies on Streptococci of Serological Group G Isolated from Various Origins

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