Acute Genotoxic Stress-Induced Senescence in Human Mesenchymal Cells Drives a Unique Composition of Senescence Messaging Secretome (SMS)

Gaur, Meenakshi; Wang, Lu; Àlex,; Amaro-Ortiz, ra; Dobke, Marek; Jordan, I. King; Lunyak, Victoria V.

doi:10.4172/2157-7633.1000396

Cited by 6 publications

(4 citation statements)

References 64 publications

(134 reference statements)

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“…Interestingly, the studies investigating induction of MSC senescence by oxidative stress, doxorubicin, and bleomycin treatments, as well as irradiation (IR), have outlined the seemingly similar signaling pathways among different stress-inducer stimuli, that confer to the common paracrine circuit that we will discuss later (Ozcan et al, 2016 ; Gaur et al, 2017b ). However, different inducers of senescence promote a preferential use of different metabolic pathways impacting on senescent cells metabolic flexibility (Capasso et al, 2015 ).…”

Section: Senescence: One Terminology-many Facesmentioning

confidence: 99%

“…Column two shows the senescence-associated inflammatory responses (SIR) from intestinal cells (Pribluda et al, 2013 ). The third from the left column lists SMS from adipose-derived mesenchymal stem cells induced to senescence by bleomycin (Gaur et al, 2017b ). Common proteins are highlighted in bold red.…”

Section: Senescence Messaging Secretome (Sms)mentioning

confidence: 99%

“…In parallel with other cellular models, different modes of MSC senescence might considerably alter the composition of MSC secretome (Capasso et al, 2015 ; Ozcan et al, 2016 ; Gaur et al, 2017b ) resulting in impairment or enhancement of the key MSC biological functions.…”

Section: Senescence Messaging Secretome (Sms)mentioning

confidence: 99%

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Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective

2017

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Mesenchymal stem/stromal cells (MSC) have been tested in a significant number of clinical trials, where they exhibit regenerative and repair properties directly through their differentiation into the cells of the mesenchymal origin or by modulation of the tissue/organ microenvironment. Despite various clinical effects upon transplantation, the functional properties of these cells in natural settings and their role in tissue regeneration in vivo is not yet fully understood. The omnipresence of MSC throughout vascularized organs equates to a reservoir of potentially therapeutic regenerative depots throughout the body. However, these reservoirs could be subjected to cellular senescence. In this review, we will discuss current progress and challenges in the understanding of different biological pathways leading to senescence. We set out to highlight the seemingly paradoxical property of cellular senescence: its beneficial role in the development and tissue repair and detrimental impact of this process on tissue homeostasis in aging and disease. Taking into account the lessons from the different cell systems, this review elucidates how autocrine and paracrine properties of senescent MSC might impose an additional layer of complexity on the regulation of the immune system in development and disease. New findings that have emerged in the last few years could shed light on sometimes seemingly controversial results obtained from MSC therapeutic applications.

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Section: Senescence: One Terminology-many Facesmentioning

confidence: 99%

Section: Senescence Messaging Secretome (Sms)mentioning

confidence: 99%

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Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective

2017

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“…possibly retinoids) genotoxic/genostimulatory drug-based or mesenchymal stem cells therapies by imposing interference with tissue homeostasis, reduction of inflammation, metabolic enhancement and regeneration in autocrine and paracrine fashion. 70,71…”

Section: Introductionmentioning

confidence: 99%

Regenerative and stem cell-based techniques for facial rejuvenation

Crowley

Liu

Dobke

2021

Exp Biol Med (Maywood)

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This review discusses the most novel ideas and modalities being incorporated into facial rejuvenation. Recent innovative techniques include the use of regenerative stem cell techniques and regeneration supportive modalities such as nano-technology or gene therapies. This review aims to investigate approaches that are less well known and lacking established evidence in order to proactively study these techniques prior to them becoming popularized. These applications and relevant research were reviewed in the context of both surgical and non-surgical modalities in clinical practice. Future directions include the concept of “precision cosmetic medicine” utilizing gene editing and cellular therapies to tailor rejuvenation techniques based on each individual’s genetic make-up and therefore needs.

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Methods and Strategies for Procurement, Isolation, Characterization, and Assessment of Senescence of Human Mesenchymal Stem Cells from Adipose Tissue

Gaur

Dobke

Lunyak³

2018

Stem Cells and Aging

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Acute Genotoxic Stress-Induced Senescence in Human Mesenchymal Cells Drives a Unique Composition of Senescence Messaging Secretome (SMS)

Cited by 6 publications

References 64 publications

Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective

Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective

Regenerative and stem cell-based techniques for facial rejuvenation

Methods and Strategies for Procurement, Isolation, Characterization, and Assessment of Senescence of Human Mesenchymal Stem Cells from Adipose Tissue

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