Acute, generalized panniculitis with amylase and lipase in skin

Forstrom, T. L.

doi:10.1001/archderm.111.4.497

Cited by 18 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24 There have been several case reports in which a patient had extensive subcutaneous fat necrosis but a relatively normal pancreas at the time of autopsy. 25 This supports the speculation that other unknown factors may be playing a role. Immune-mediated injury has also been implicated in the etiology of pancreatic panniculitis.…”

Section: Discussionsupporting

confidence: 74%

A fatal case of pancreatic panniculitis presenting in a young patient with systemic lupus

et al. 2000

View full text Add to dashboard Cite

Background: Subcutaneous fat necrosis associated with pancreatic disease is a rare event. The clinical cutaneous findings are non‐specific erythematous nodules with central softening located predominantly on the lower extremities. The histopathologic features of these lesions are very characteristic and diagnostic. Methods: We present an unusual case of pancreatic panniculitis associated with lupus pancreatitis in a 21‐year‐old African American female. The patient presented with lower extremity skin nodules, arthralgia, and serositis prior to the diagnosis of systemic lupus and pancreatitis. The skin lesions progressed despite normalization of serum pancreatic enzymes. Following femoral vein catheterization for renal dialysis, she developed a large indurated area over the left lower quadrant, flank, groin, and upper thigh measuring 25 cm. She was treated with repeated debridement, tissue grafts, and hyperbaric oxygen because of a clinical suspicion of necrotizing fasciitis. Results: Examination of skin biopsies and debrided tissue revealed the pathognomonic features of pancreatic panniculitis without any evidence of necrotizing fasciitis. Organisms were not detected by tissue examination or microbiologic cultures. Conclusions: This case illustrates the potential role of vascular trauma in the pathogenesis of pancreatic panniculitis.

show abstract

Section: Discussionsupporting

confidence: 74%

A fatal case of pancreatic panniculitis presenting in a young patient with systemic lupus

et al. 2000

View full text Add to dashboard Cite

show abstract

“…The main enzyme incriminated is lipase. This observation had been supported by finding increased lipase within the skin of a patient with panniculitis and polyarthritis (Forstrum 1975). Other enzymes, which may be involved, include trypsin and phospholipase A (Wilson and others 1983).…”

Section: Discussionmentioning

confidence: 87%

Panniculitis, polyarthritis and osteomyelitis associated with pancreatic neoplasia in two dogs

Gear¹,

Bacon

Langley‐Hobbs

et al. 2006

J of Small Animal Practice

View full text Add to dashboard Cite

A 12-year-old crossbred dog (case 1) and a 12-year-old Shetland sheepdog (case 2) were presented with a history of lameness and distal limb swelling. Physical examination revealed joint effusions and asymmetrical swellings of the extremities. In case 1, a diagnosis of arthritis and cellulitis was made on fine-needle aspiration biopsy of the synovium and subcutis. In case 2, bone biopsies and synovial aspirates diagnosed osteomyelitis and arthritis. A diagnosis of pancreatic disease was made on the findings of marked elevations of serum lipase concentrations and ultrasonographic identification of pancreatic masses in both cases. Both the cases were non-responsive to symptomatic management and were subsequently euthanased. Postmortem examination confirmed the diagnosis of panniculitis, arthritis and osteomyelitis in both cases. A pancreatic exocrine adenoma was identified in case 1 and a pancreatic adenocarcinoma with widespread metastases in case 2. To the authors' knowledge the association of panniculitis, polyarthritis and osteomyelitis with pancreatic disorders has not been reported previously in canine clinical cases.

show abstract

“…In other patients, however, there was no demonstrable pancreatic disease, although high serum levels of pancreatic lipase of unknown origin were detected. 2 Pancreatic enzymes, mostly lipase, that escape into the bloodstream from the inflamed pancreas seem to be responsible for the subcutaneous fat necrosis in enzymatic panniculitis. 2,3 The finding of pancreatic lipase in the lesions of pancreatic panniculitis, 2 and the immunohistochemical demonstration with anti-lipase monoclonal antibodies of that enzyme within the necrotic adipocytes, 4 support the pathogenic role of pancreatic lipase.…”

Section: Introductionmentioning

confidence: 99%

“…2 Pancreatic enzymes, mostly lipase, that escape into the bloodstream from the inflamed pancreas seem to be responsible for the subcutaneous fat necrosis in enzymatic panniculitis. 2,3 The finding of pancreatic lipase in the lesions of pancreatic panniculitis, 2 and the immunohistochemical demonstration with anti-lipase monoclonal antibodies of that enzyme within the necrotic adipocytes, 4 support the pathogenic role of pancreatic lipase. Histopathologically, pancreatic panniculitis is a mostly lobular panniculitis with intense necrosis of the adipocytes at the center of the fat lobule.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous and mucosal mucormycosis mimicking pancreatic panniculitis and gouty panniculitis

Requena

Sitthinamsuwan

Santonja

et al. 2012

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Acute, generalized panniculitis with amylase and lipase in skin

Cited by 18 publications

References 0 publications

A fatal case of pancreatic panniculitis presenting in a young patient with systemic lupus

A fatal case of pancreatic panniculitis presenting in a young patient with systemic lupus

Panniculitis, polyarthritis and osteomyelitis associated with pancreatic neoplasia in two dogs

Cutaneous and mucosal mucormycosis mimicking pancreatic panniculitis and gouty panniculitis

Contact Info

Product

Resources

About