Acute Generalized Miliary Tuberculosis in Adults

Chapman, C B; Whorton, C. Merrill

doi:10.1056/nejm194608222350801

Cited by 85 publications

(20 citation statements)

References 12 publications

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“…Only one of these was suspected of having tuberculosis before death. The advanced ages of the patients and the short duration of antituberculosis therapy in those treated before death is apparent from (Hartwich, 1922;Chapman and Whorton, 1946;Biehl, 1958) (Barrett-Connor, 1967), the majority of the very elderly in this series are likely to have been infected early in life. Nevertheless, the allergic response to the tubercle bacillus, as measured by skin tuberculin sensitivity, declines after the age of 50 years (Johnston, Ritchie, and Murray, 1963) Pancytopenia complicating tuberculosis has been reported by Fountain (1954), Medd and Hayhoe (1955), and Dawborn and Cowling (1961) and more recently in association with disseminated atypical mycobacterial infection (Zamorano and Tompsett, 1968).…”

Section: Haematological Findingsmentioning

confidence: 83%

Miliary Tuberculosis in Adults

Proudfoot¹,

Akhtar²,

Douglas³

et al. 1969

BMJ

170

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Section: Haematological Findingsmentioning

confidence: 83%

Miliary Tuberculosis in Adults

Proudfoot¹,

Akhtar²,

Douglas³

et al. 1969

BMJ

170

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“…Acute disease is rare and may occur in advanced HIV/AIDS or other immunocompromised states [6]. It is usually fulminant, including multiorgan system failure, septic shock and acute respiratory distress syndrome (ARDS) [8,9]. Therefore, miliary tuberculosis should always be considered in patients with ARDS of unknown etiology especially if risk factors are present [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Miliary tuberculosis in an immunocompetent male

Agu¹,

Patolia²,

Basheer³

2014

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.IJCRI publishes Review Articles, Case Series, Case Reports, Case in Images, Clinical Images and Letters to Editor. Website: www.ijcasereportsandimages.com Miliary tuberculosis in an immunocompetent maleChidozie Charles Agu, Patolia Setu, Hiba Basheer ABSTRACT Introduction: Miliary tuberculosis (TB) is a disseminated form of tuberculosis which may involve the lungs and other organs. It is a rare but potentially lethal form of tuberculosis seen mostly in immunocompromised patients. It is, however, not commonly reported in immunocompetent hosts. Case Report: We present a case of a 67-year-old African-American male who presented with persistent non-productive cough for three weeks, diarrhea, fatigue and weight loss. There was no history of active TB contacts, HIV infection, or other predisposing factor for immunosuppression. Physical examination was also unremarkable. Chest X-ray and computed tomography scan revealed bilateral extensive small nodular infiltrates with negative serial acidfast sputum smears. Acid-fast bacilli were detected in sputum culture at four weeks and were identified by DNA probe as Mycobacterium tuberculosis. Conclusion: Miliary tuberculosis is a potentially lethal form of tuberculosis that mostly affects immunosuppressed patients, although in rare occasions can also affect immunocompetent adults.

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“…Tuberculose miliar ainda permanece a infecção a ser considerada acima de todas em qualquer doença febril crônica sem ex plicação (5) . Isto torna-sc mais impor tante principalmente em nosso país, um conseqüência da alta incidência da doen ça, desde que condições propícias existem por falhas no controle epidemiológico e pelas próprias condições sôcio-econòmicas existentes.…”

Section: Discussionunclassified