Acute Generalized Exanthematous Pustulosis in Children

Acute generalized exanthematous pustulosis in children and adolescents in Singapore: A ten‐year retrospective review

“…The youngest case described was 5 months. 5 The clinical presentation of our patients was similar to the presentation of AGEP in other pediatric populations and in adults with regard to the acute time course, presence of fever and prodromal symptoms, clinical morphology of pustulosis with marked erythema, and infrequent and limited mucous membrane involvement. Also, quick resolution of acute pustulosis and post-pustular desquamation was found.…”

“…17 However, other studies have shown good recovery outcomes without systemic steroids. 5,26 Our study has its limitations. Firstly, as it is a retrospective study, data were limited to the information available.…”

“…12,13 Ersoy et al reported viral infections as a cause in 4 of their 5 cases of AGEP in pediatric patients. 5 Streptococcus pyogenes fasciitis and primary EBV infection were reported as causes of AGEP by Kaneko et al and Ropars et al, respectively. 6,12 Our study also found infective triggers to be more common in children.…”

Acute generalized exanthematous pustulosis due to ceftriaxone: Report of a pediatric case with recurrence after positive patch test

“…The most common culprit drugs are beta‐lactam antibiotics including ceftriaxone, as in our patient . It is less frequently reported in children and may be associated with atypical clinical features such as localized edema and targetoid lesions when occurring within this population, as was observed in the present case …”

“…Acute generalized exanthematous pustulosis (AGEP) is seldom described in children . Although confirmation of the drug through patch testing is well established in delayed‐type cutaneous drug reactions, we have found only one pediatric case with ceftriaxone‐induced AGEP confirmed through patch testing .…”