Acute generalized exanthematous pustulosis. Analysis of 63 cases

Dermatoses neutrofílicas: parte II

“…32 However, due to its particular clinical characteristics such as sudden onset of numerous follicular pustules over an exanthem, accompanied by fever, history of frequent use of medication, histopathological differences and rapid spontaneous resolution, the authors considered it as a different entity from psoriasis. Some authors acknowledge that pustular psoriasis and AGEP may share a genetic background that would lead to the attraction of neutrophils [32][33][34][35] The most frequent causes of AGEP are reactions to acute infections (enterovirus), to drugs and mercury. 34 Although the infectious etiology of AGEP is still controversial, 32.36 there are reports of patients with skin lesions compatible with AGEP during an infectious process without use of any medication.…”

“…Some authors acknowledge that pustular psoriasis and AGEP may share a genetic background that would lead to the attraction of neutrophils [32][33][34][35] The most frequent causes of AGEP are reactions to acute infections (enterovirus), to drugs and mercury. 34 Although the infectious etiology of AGEP is still controversial, 32.36 there are reports of patients with skin lesions compatible with AGEP during an infectious process without use of any medication. 34,35,37 Approximately 90% of the cases are caused by medication.…”

“…34 Although the infectious etiology of AGEP is still controversial, 32.36 there are reports of patients with skin lesions compatible with AGEP during an infectious process without use of any medication. 34,35,37 Approximately 90% of the cases are caused by medication. 34.38 Among the drugs commonly associated with the development of AGEP are antibiotics (macrolides and beta-lactams), antifungals, calcium channel blockers, carbamazepine, paracetamol, anti-malarial drugs, among others.…”

“…33,35,36 The time between drug administration and the appearance of lesions may be less than 24 hours in some cases. 34 Some authors suggest that this period is on average shorter after the use of antibacterial drugs. 33,35,36 In cases with no previous sensitization or when the drug involved is not an antibiotic, the interval between onset of lesions and start of treatment is from one to three weeks.…”

A Case with Acute Generalized Exanthematous Pustulosis Due to Iopromide: Differential Diagnosis

“…Over 90% of cases of AGEP are induced by systemic drug treatment, mainly antibiotics such as β-lactams and non-steroidal anti-inflammatory agents. 1 In this article, we report a case of AGEP in a 50 year old man who was administered Ultravist® (Iopromide) for thoracic computerized tomography. To A Case with Acute Generalized Exanthematous Pustulosis Due to Iopromide: Differential Diagnosis A AB BS S T TR RA AC CT T Acute generalized exanthematous pustulosis is a rare cutaneous reaction characterized by generalised non-follicular, pinhead-sized, sterile pustules on an erythematous background.…”