Acute Fibrinoid Organizing Pneumonia after Lung Transplantation

Abstract

AFOP is a novel form of chronic allograft dysfunction exhibiting spirometric, radiological, and histopathological characteristics that differentiate it from OB. The further characterization of chronic allograft dysfunction and its heterogeneous manifestations will allow the targeting of clinical and experimental efforts to prevent and treat chronic allograft dysfunction.

Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop

“…Finally, there is currently an unmet need for new models of RAS, an increasingly recognized manifestation of CLAD. Further work needs to be done in modeling other histologic manifestations of CLAD such as pleural and parenchymal upper lobe-dominant fibrosis that has been demonstrated in patients presenting with restrictive CLAD and the recently described acute fibrinous pneumonitis (135).…”

Successful Lung Retransplantation in a Patient With Acute Fibrinous and Organizing Pneumonia: A Case Report

“…AFOP has recently been described as a novel form of chronic lung allograft dysfunction [9]. The original study cohort consisted of 194 patients who received bilateral lung transplantation [9].…”

Update in Lung Transplantation 2013

“…Patients with AFOP were more likely to have nonobstructive physiology and radiographic patterns inconsistent with BOS, such as ground-glass changes and interlobular septal thickening. Interestingly, the histology of AFOP is distinct from that of DAD and was not observed concurrent with DAD; hence, although it is clear that both RAS and AFOP are divergent from BOS, it remains uncertain to what extent AFOP and RAS overlap (48).…”