Acute Exacerbation of Interstitial Pneumonia Other Than Idiopathic Pulmonary Fibrosis

Park, I-Nae; Kim, Dong Soon; Shim, Tae Sun; Lim, Chae‐Man; Lee, Sang Do; Koh, Younsuck; Kim, Woo Sung; Kim, Won Dong; Jang, Se Jin; Colby, Thomas V.

doi:10.1378/chest.07-0323

Cited by 319 publications

(318 citation statements)

References 38 publications

Supporting

Mentioning

288

Contrasting

Unclassified

Order By: Relevance

“…Moreover, AE-ILD occurred at a frequency of 9.4% (13/139) in our study. Previous papers showed that the 1-year frequency of acute exacerbation was 1.25%-3.3% and a lifetime incidence 7.2% in patients with connective tissue disease (Park et al 2007;Suda et al 2009). …”

Section: Discussionmentioning

confidence: 99%

“…Cyclophosphamide was demonstrated to stabilize lung function in a randomized controlled trial, but its beneficial effect disappeared at 24 months (Tashkin et al 2006;Tashkin et al 2007). Moreover, acute exacerbation of ILD (AE-ILD) occurs at a 1-year frequency of 1.25%-3.3% and at a lifetime incidence of 7.2%, with a high mortality rate in patients with connective tissue disease (Park et al 2007;Suda et al 2009). Given the chronic nature of the disease, it has been considered that AE-ILD is not common in patients with SSc (Fan et al 2014;Cappelli et al 2015), but recent papers suggest that AE-ILD may occur even in patients with SSc (Park et al 2007;Bussone and Mouthon 2011;Tachikawa et al 2012;Ando et al 2013;Yasuoka 2016).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High Prevalence of Acute Exacerbation of Interstitial Lung Disease in Japanese Patients with Systemic Sclerosis

Tomiyama

Watanabe

Ishii

et al. 2016

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by extensive fibrosis and autoantibodies. Its clinical manifestations are diverse and include Raynaud's phenomenon, gastrointestinal dysmotility, interstitial lung disease (ILD), pulmonary hypertension, and renal crisis. Among these, ILD is the primary cause of SSc-related death. It has been considered that acute exacerbation of ILD (AE-ILD) is not common in patients with SSc; however, little is known about the prevalence of AE-ILD in Japanese patients with SSc. In this study, we aimed to clarify the prevalence, clinical characteristics, and prognosis of patients with SSc who developed AE-ILD and to identify predictive factors for AE-ILD in our Japanese cohorts. Clinical data of patients who visited our department from 1990 to 2014 and fulfilled the 2013 classification criteria for SSc were retrospectively reviewed. A total of 139 patients were enrolled. The mean age of onset was 49.1 years, and 113 (81.3%) patients were female; 116 (83.5%) had limited cutaneous involvement, and the overall 10-year survival rate was 92.0%. Among 66 (47.5%) patients with ILD, 13 (9.4%) developed AE-ILD. Patients with AE-ILD had a significantly higher incidence of overlap with polymyositis (PM) or dermatomyositis (DM) and lower prevalence of anticentromere antibodies with higher mortality rate compared with those without AE-ILD. Multivariate Cox regression analysis identified that an overlap with PM or DM was the most significant predictive factor for AE-ILD. Our study results suggest that Japanese patients with SSc, particularly patients overlapped with PM or DM, have a high risk of AE-ILD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High Prevalence of Acute Exacerbation of Interstitial Lung Disease in Japanese Patients with Systemic Sclerosis

Tomiyama

Watanabe

Ishii

et al. 2016

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…29,39 In a study of a large cohort of 93 subjects with CTD-ILD, Park et al 42 reported a 1-year incidence of acute worsening of 3.3% (four subjects). Three of these four patients had RA with proven UIP seen on a lung biopsy specimen.…”

Section: Prognostic Implicationsmentioning

confidence: 99%

Rheumatoid Arthritis-Associated Interstitial Lung Disease

Kim

Collard

King

2009

Chest

328

View full text Add to dashboard Cite

“…This should not be confused with acute exacerbation of IPF (progression of symptoms over weeks with radiographic airspace disease), as biopsies may also reveal organising pneumonia with underlying UIP in this syndrome [76,77]. MAYS et al [73] reported 131 patients with radiographic pulmonary fibrosis, of which six had recurrent aspiration as their primary diagnosis.…”

Section: Ipfmentioning

confidence: 99%

Gastro-oesophageal reflux disease and non-asthma lung disease

Morehead¹

2009

European Respiratory Review

View full text Add to dashboard Cite

Gastro-oesophageal reflux disease (GERD) is a common disorder in Western countries, and its relationship to airways disorders (e.g. asthma) has been well established. Lung diseases other than asthma have also been associated with GERD, but the nature and scope of this relationship has not been fully defined. Diseases that have been associated with GERD include bronchiolitis syndromes, idiopathic pulmonary fibrosis, scleroderma and nontubercular mycobacterial infection.Diagnostic evaluation centres upon proving both reflux and pulmonary aspiration, which may be accomplished in some cases by lung biopsy. However, in many cases a compatible clinical and radiographic picture coupled with proof of proximal reflux by combined oesophageal probe testing may suffice for a provisional diagnosis and allow institution of anti-reflux measures.Proton-pump inhibitors are the medications of choice for GERD; other interventions shown to reduce reflux are weight loss, elevation of the head of the bed and avoidance of recumbency after meals. However, acid suppression therapy does not address non-acid reflux that may be important in disease pathogenesis in select patients, and lifestyle modifications often fail.Laparoscopic fundoplication is the procedure of choice for medically refractory GERD with excellent short-term results with respect to respiratory symptoms associated with GERD; however, long-term studies document a significant percentage of patients requiring ongoing acid suppression therapy.

show abstract

Acute Exacerbation of Interstitial Pneumonia Other Than Idiopathic Pulmonary Fibrosis

Cited by 319 publications

References 38 publications

High Prevalence of Acute Exacerbation of Interstitial Lung Disease in Japanese Patients with Systemic Sclerosis

High Prevalence of Acute Exacerbation of Interstitial Lung Disease in Japanese Patients with Systemic Sclerosis

Rheumatoid Arthritis-Associated Interstitial Lung Disease

Gastro-oesophageal reflux disease and non-asthma lung disease

Contact Info

Product

Resources

About