Acute Epstein-Barr Virus Infection and Human Immunodeficiency Virus Antibody Cross-reactivity

A Case of Severe Systemic Viral Infection Associated With Intravenous Immunoglobulin G–Resistant Kawasaki Disease and Multiple False-Positive Serologic Tests: How Multiple Diseases in One Child Can Have One Simple Explanation

“…Although there are some studies that report cross-reaction between EBV and parvovirus or HIV, this case is unique in its degree of cross-reactivity with multiple immunologic markers. 8-10 The serology of the patient in this case challenges the idea of antigen mimicry between herpes viruses causing cross-reaction. CMV IgM and IgG were negative, while parvovirus IgM and IgG and HIV Ag/Ab were falsely positive with confirmed negative PCRs and a negative maternal HIV screen done before IVIG treatment was initiated.…”

Microscopy‐based assay for semi‐quantitative detection of SARS‐CoV‐2 specific antibodies in human sera

“…[ 12 ] Also, acute infection with Epstein‐Barr virus (EBV) or cytomegalovirus (CMV) may result in unspecific reactivity of human sera. [ 24,25 ] We therefore selected a negative control panel consisting of 218 sera collected before the fall of 2019, comprising samples from healthy donors (n = 105, cohort B), patients that tested positive for ccCoV several months before the blood sample was taken (n = 34, all four types of ccCoV represented; cohort A), as well as patients with diagnosed Mycoplasma pneumoniae (n = 22; cohort Z), EBV or CMV infection (n = 57, cohort E). We further selected a panel of 57 sera from 29 RT‐PCR confirmed COVID‐19 patients collected at different days’ post symptom onset as a positive sample set (cohort C, see below).…”

Acute EBV Infection and HIV Antibody Cross-Reactivity in a First Time Donor

“…In addition to flu vaccination and viral infections, false-positive HIV immunoassay results have been reported in a variety of other conditions, such as autoimmune disease, renal failure, cystic fibrosis, multiple pregnancies, blood transfusions, liver diseases, parenteral substance abuse, hemodialysis, and vaccinations against hepatitis B and rabies. [9][10][11][12][13] This should be noted by medical practitioners and labs that conduct screening tests in order to counteract traumatic social impasse. A false diagnosis of HIV infection can be proved by the combination of EIA, WB and NAT testing in blood donor.…”