Acute endophthalmitis following intravitreal triamcinolone acetonide injection

Moshfeghi, Darius M.; Kaiser, Peter K.; Scott, Ingrid U.; Sears, Jonathan E.; Benz, Matthew S.; Sinesterra, Juan P.; Kaiser, Richard; Bakri, Sophie J.; Maturi, Raj K.; Belmont, Jonathan B.; Beer, Paul M.; Murray, Timothy G.; Quiroz‐Mercado, Hugo; Mieler, William F.

doi:10.1016/s0002-9394(03)00483-5

Cited by 401 publications

(260 citation statements)

References 25 publications

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“…Moshfeghi et al 27 reported several cases of endophthalmitis after ivTA injection. It was suggested that diabetes due to its association with immunosuppression, 27,28 may be a risk factor for endophthalmitis after ivTA injections, and the authors recommended that in such patients consideration be given to delaying the procedure. However, diabetics with macular oedema make up a large proportion of patients who could potentially benefit from ivTA.…”

Section: Discussionmentioning

confidence: 99%

Phacoemulsification with intravitreal triamcinolone in patients with cataract and coexisting diabetic macular oedema: a 6-month prospective pilot study

Lam

Chan

Mohamed

et al. 2004

Eye

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Aims To assess the safety and efficacy of phacoemulsification with intravitreal triamcinolone (ivTA) injection in diabetics with cataract and clinically significant macular oedema (CSMO). Methods A total of 19 eyes of 15 consecutive diabetic patients with cataract and CSMO were prospectively recruited. Patients underwent phacoemulsification and intraocular lens implantation with 4 mg ivTA injection at completion of surgery. Patients were followed up on day 1, then weekly for 1 month, and thereafter monthly until 6 months postoperatively. Best corrected visual acuity (BCVA), central macular thickness (CMT) measured by optical coherence tomography, and adverse events were recorded. Results In total, 17 eyes completed 6 months of follow-up. In all, 58.8% showed improvement in BCVA of X2 lines, with statistically significant improvement in mean Snellen BCVA of 2.4 lines at 6 months. The peak BCVA was achieved at 4 months. The mean CMT decreased from a baseline of 449 mm to a minimum of 3217148 mm (28.5% reduction) achieved at 2 months, with statistically significant reduction at all postoperative time intervals until 6 months. Of 17 eyes, 4 (23.5%) developed transiently elevated intraocular pressure that normalised by 6 months in all but one patient. No injection-or surgery-related complications were encountered.Conclusions Phacoemulsification with concurrent 4 mg ivTA injection appears to be a safe option for managing diabetics with cataract and CSMO. However, large-scaled randomised controlled trials are necessary for delineating the relative contributions of cataract removal and CMT reduction to visual improvement. Moreover, the transient effect on CMT may warrant further studies to determine optimal timing and dosage of further ivTA injections.

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Section: Discussionmentioning

confidence: 99%

Phacoemulsification with intravitreal triamcinolone in patients with cataract and coexisting diabetic macular oedema: a 6-month prospective pilot study

Lam

Chan

Mohamed

et al. 2004

Eye

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“…In addition, there have been reports of potentially serious ocular complications, including raised intraocular pressure (IOP) 6 and endophthalmitis (sterile 7 and infective 8 ) following intravitreal triamcinolone acetonide injection.…”

Section: Introductionmentioning

confidence: 99%

Intravitreal triamcinolone acetonide for macular oedema owing to retinal vein occlusion

Patel

Zaheer

Karia

2006

Eye

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“…Transient ocular hypertension and cataract are the most common complications occurring in 30 and 10% of patients, respectively. [1][2][3][4] Globe rupture to date has not to our knowledge been reported. …”

Section: Commentmentioning

confidence: 89%

“…Few reports have documented adverse events including intractable glaucoma, endophthalmitis, intraocular haemorrhage, and hypotony. [1][2][3][4] We report a case of scleral rupture as a complication of this procedure.…”

Section: Sir Globe Rupture As a Complication Of Intravitreal Injectimentioning

confidence: 98%

Globe rupture as a complication of intravitreal injection of triamcinolone

Ung

Williams

Canning

2006

Eye

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Acute endophthalmitis following intravitreal triamcinolone acetonide injection

Cited by 401 publications

References 25 publications

Phacoemulsification with intravitreal triamcinolone in patients with cataract and coexisting diabetic macular oedema: a 6-month prospective pilot study

Phacoemulsification with intravitreal triamcinolone in patients with cataract and coexisting diabetic macular oedema: a 6-month prospective pilot study

Intravitreal triamcinolone acetonide for macular oedema owing to retinal vein occlusion

Globe rupture as a complication of intravitreal injection of triamcinolone

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