Acute Encephalitic Syndrome Induced by Scleromyxedema

Dermato‐neuro syndrome after COVID‐19 infection in a patient with scleromyxoedema: Previously successful treatment with intravenous immunoglobulins

“…The exact pathogenesis of DNS is unknown. According to some research, paraproteinemia causes leukocyte aggregation or increases blood viscosity, both of which cause microcirculatory stasis in the central nervous system 9 . The production and release of the proinflammatory cytokine IL‐6 increases during viral infections such as influenza A or SARS‐CoV‐2.…”

“…According to some research, paraproteinemia causes leukocyte aggregation or increases blood viscosity, both of which cause microcirculatory stasis in the central nervous system. 9 The production and release of the proinflammatory cytokine IL-6 increases during viral infections such as influenza A or SARS-CoV-2. IgG levels in the cerebral microvasculature may rise as a result of increased blood-brain barrier 3 recently reported the first case of a patient with SMX who experienced a DNS attack after infection with influenza A and SARS-CoV-2.…”

Therapy of disorders with organ dysfunctions related to "Monoclonal Gammopathy of Clinical Significance" - MGCS

“…Podrobnější informace o léčbě IVIG jsou uvedeny v české literatuře (14,15). V popisech jednotlivých chorob ze skupiny MGCS v knize "Monoklonální gamapatie klinického významu a jiné nemoci" se pak uvádí zkušenosti s léčbou IVIG (16)(17)(18)(19).…”

SARS-CoV-2: A potential trigger of dermato-neuro syndrome in a patient with scleromyxedema

“…5,6 Enhanced blood-brain-barrier permeability in the setting of monoclonal gammopathy may elevate IgG levels in the brain microvasculature, causing hyperviscosity, sludging, and neurologic abnormalities. [7][8][9] Available literature indicates that reported cases of DNS are frequently preceded by a flu-like prodrome 3,4,[9][10][11][12][13][14][15][16][17][18] or other suspected upper respiratory tract infection. 8,19 Notably, 2 case studies identified influenza A infection in association with DNS.…”