Acute effects of methadone on EEG power spectrum and event-related potentials among heroin dependents

Motlagh, Farid; Ibrahim, Fatimah; Rashid, Rusdi Abd; Shafiabady, Niusha; Seghatoleslam, Tahereh; Habil, Hussain

doi:10.1007/s00213-018-5035-0

Cited by 14 publications

(13 citation statements)

References 91 publications

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“…Consistent with previous reports [23, 26, 39, 64], we demonstrate that changes in spectral rhythms took place in some, but not all 19 electrodes of patients with opioid use disorder. Major changes were found at F3, F4, Fz, and Cz.…”

Section: Discussionsupporting

confidence: 93%

“…Nevertheless, the data support the notion that spectral powers are characteristically distributed across the cortex, which can be considered as fundamental values in estimating mental health. Second, we found that changes in spectral powers were characteristic of patients with opioid use disorder, consistent with previous opioid research reports [26, 30]. A majority of 19 electrodes could detect an increase of δ but not θ , α , β , or γ powers.…”

Section: Discussionsupporting

confidence: 91%

“…An advantage of such a categorization is that it allows the spectral powers to associate with specific brain areas. However, additional verification is needed to determine whether functional activity relevant to areas is indeed modulated or impaired in association with changes in spectral activity, which could be explored with event-related potential (ERP) measurements in patients with opioid abuse [26].…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Wang et al reported equal increases of δ , θ , α , and β powers in almost all EEG electrodes placed on the scalp [25]. Motlagh showed that β but not δ , θ , or α oscillations were increased in opioid patients [26]. Although causes of inconsistency between reports are unknown, it suggests that it is necessary and also needed to re-evaluate the relationship of EEG electrodes and rhythms altered in opioid patients.…”

Section: Introductionmentioning

confidence: 99%

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Estimating Mental Health Conditions of Patients with Opioid Use Disorder

Minnerly

Bressler

Shokry

et al. 2019

Journal of Addiction

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Objectives Noninvasive estimation of cortical activity aberrance may be a challenge but gives valuable clues of mental health in patients. The goal of the present study was to characterize specificity of electroencephalogram (EEG) electrodes used to assess spectral powers associated with mental health conditions of patients with opioid use disorder. Methods This retrospective study included 16 patients who had been diagnosed with opioid use disorder in comparison with 16 sex- and age-matched healthy controls. EEG electrodes were placed in the frontal (FP1, FP2, F3, F4, F7, F8, and Fz), central (C3, C4, and Cz), temporal (T3, T4, T5, and T6), parietal (P3, P4, and Pz), and occipital scalp (O1 and O2). Spectral powers of δ, θ, α, β, and γ oscillations were determined, and their distribution was topographically mapped with those electrodes on the scalp. Results Compared to healthy controls, the spectral powers at low frequencies (<8 Hz; δ and θ) were increased in most electrodes across the scalp, while powers at the high frequencies (>12 Hz; β and γ) were selectively increased only at electrodes located in the frontal and central scalp. Among 19 electrodes, F3, F4, Fz, and Cz were highly specific in detecting increases in δ, θ, β, and γ powers of patients with opioid use disorders. Conclusion Results of the present study demonstrate that spectral powers are topographically distributed across the scalp, which can be quantitatively characterized. Electrodes located at F3, F4, Fz, and Cz could be specifically utilized to assess mental health in patients with opioid use disorders. Mechanisms responsible for neuroplasticity involving cortical pyramidal neurons and μ-opioid receptor regulations are discussed within the context of changes in EEG microstates.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Estimating Mental Health Conditions of Patients with Opioid Use Disorder

Minnerly

Bressler

Shokry

et al. 2019

Journal of Addiction

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“… 57 , 58 Furthermore, β rhythm is closely related to cognitive function, having the right amount of power allows subjects to focus easily and less amount of power may lead to poor cognition. 59 Consistent with the results of delta and β frequency bands in CA1, the experimental mouse was similar to the normal control mouse, while the power of the toxicity control mouse was higher in delta and was obviously lower in β than the other two groups of mice. It was further indicated that the ultrahigh injected dose of Au 25 clusters hardly caused any damage to the nerve compared with the toxicity group, which was consistent with the conclusion of that in CA1.…”

Section: Resultssupporting

confidence: 82%

In Vivo Neuroelectrophysiological Monitoring of Atomically Precise Au₂₅ Clusters at an Ultrahigh Injected Dose

Hao

Liu

et al. 2020

ACS Omega

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Atomically precise Au 25 (SG) 18 clusters have shown great promise in near-infrared II cerebrovascular imaging, X-ray imaging, and cancer radiotherapy due to their high atomic number, unique molecular-like electronic structure, and renal clearable properties. Therefore, it is important to study the in vivo toxicity of Au 25 clusters. Unfortunately, previous toxicological investigations focused on low injected doses (<100 mg kg –1 ) and routine research methods, such as blood chemistry and biochemistry, which cannot reflect neurotoxicity or tiny changes in neural activity. In this work, in vivo neuroelectrophysiology of Au 25 clusters at ultrahigh injected doses (200, 300, and 500 mg kg –1 ) was investigated. Local field potential showed that the Au 25 -treated mice showed a spike in delta rhythm and moved to lower frequency over time. The power spectrum showed a 38.3% reduction in the peak value at 10 h post-injection of Au 25 clusters compared with 3 h post-injection, which gradually became close to the normal level, indicating no permanent damage to the nervous system. Moreover, no significant structural changes were found in both neurons and glial cells at the histological level. These results of in vivo neuroelectrophysiology will encourage scientists to make more exciting discoveries on nervous system diseases by employing Au 25 clusters even at ultrahigh injected doses.

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Effect of Methadone on the Brain Activity in Close Eyes Condition

Turnip

Kusumandari

Sobana

et al. 2021

Advances in Intelligent Systems and Computing

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Acute effects of methadone on EEG power spectrum and event-related potentials among heroin dependents

Cited by 14 publications

References 91 publications

Estimating Mental Health Conditions of Patients with Opioid Use Disorder

Estimating Mental Health Conditions of Patients with Opioid Use Disorder

In Vivo Neuroelectrophysiological Monitoring of Atomically Precise Au₂₅ Clusters at an Ultrahigh Injected Dose

Effect of Methadone on the Brain Activity in Close Eyes Condition

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Acute effects of methadone on EEG power spectrum and event-related potentials among heroin dependents

Cited by 14 publications

References 91 publications

Estimating Mental Health Conditions of Patients with Opioid Use Disorder

Estimating Mental Health Conditions of Patients with Opioid Use Disorder

In Vivo Neuroelectrophysiological Monitoring of Atomically Precise Au25 Clusters at an Ultrahigh Injected Dose

Effect of Methadone on the Brain Activity in Close Eyes Condition

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In Vivo Neuroelectrophysiological Monitoring of Atomically Precise Au₂₅ Clusters at an Ultrahigh Injected Dose