Acute effects of exercise on plasma catecholamines in sedentary and athletic women with normal and abnormal menses

Chin, NeeOo W.; Chang, Frank E.; Dodds, William G.; Kim, Moon H.; Malarkey, William B.

doi:10.1016/s0002-9378(87)80092-3

Cited by 14 publications

(4 citation statements)

References 14 publications

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“…There does not ap pear to be a difference in either basal dopamine levels or their response to exercise between oligoamenorrheic and eumenorrheic runners. 97 There are no significant differences in basal or exercise-stimulated epinephrine levels. In contrast, the response of norepinephrine to exercise was greater in women with reproductive abnormalities compared with eumenorrheic women.…”

Section: The Endocrinology Of Exercise-associated Reproductive Dysfunmentioning

confidence: 90%

“…In contrast, the response of norepinephrine to exercise was greater in women with reproductive abnormalities compared with eumenorrheic women. 97 The authors suggested that these differences in exercise-induced fluctuation of norepinephrine could influence the menstrual cycle. The peripheral changes in catecholamines with exercise result from activation of the sympathoadrenal system, 98 and any claims that there is a direct effect of such changes on the hypothalamus must accommodate the problem of the blood-brain barrier.…”

Section: The Endocrinology Of Exercise-associated Reproductive Dysfunmentioning

confidence: 99%

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Physical Activity and Control of the Hypothalamic-Pituitary-Gonadal Axis

Cumming¹

1990

Semin Reprod Med

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Section: The Endocrinology Of Exercise-associated Reproductive Dysfunmentioning

confidence: 90%

Section: The Endocrinology Of Exercise-associated Reproductive Dysfunmentioning

confidence: 99%

Physical Activity and Control of the Hypothalamic-Pituitary-Gonadal Axis

Cumming¹

1990

Semin Reprod Med

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“…Obesity also can result in anovulatory bleeding because fat tissue metabolizes ovarian and adrenal androstenedione into estrone, which is a weak estrogen that inhibits induction of ovulation (Farrell, 1986). Chin, Chang, Dodds, Kim, and Malarkey (1987) reported that women runners had marked elevations of plasma catecholamine levels during maximal exercise and that the norepinephrine levels were significantly higher in the runners with menstrual dysfunction than the control group. The researchers postulated that the increased catecholamine levels were associated with a decrease in the LH secretion and anovulatory cycles.…”

Section: Physiology and Pathophysiology Of Menstruationmentioning

confidence: 99%

Dysfunctional Uterine Bleeding

Kholny

1993

Journal of the American Academy of Nurse Practitioners

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Dysfunctional uterine bleeding (DUB) is a common gynecologic problem, occurring most frequently at the extremes of a woman's reproductive life. The primary cause of DUB is anovulation; however, because DUB is a diagnosis of exclusion, a detailed history and a thorough physical and pelvic examination with appropriate diagnostic tests are essential in order to rule out other pathologic causes of abnormal uterine bleeding. Knowledge of the physiologic basis, differential diagnoses, and diagnostic and management modalities for DUB enables the nurse practitioner to provide optimal care for the patient.

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“…Sympathoadrenal activity increases proportionately with the intensity of the exercise and is closely associated with oxygen availability (2,5). In their recent study, Schaal et al (8) observed reduced plasma norepinephrine (NE) responses to an acute exercise in amenorrheic women when compared to foUicular-phase eumenorrheie women.…”

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confidence: 99%

Catecholamine Responses to Acute and Chronic Exercise According to Menstrual Status

Crée¹

2011

Medicine &Amp; Science in Sports &Amp; Exercise

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CATECHOLAMINE RESPONSES TO ACUTE AND CHRONIC EXERCISE ACCORDING TO MENSTRUAL STATUSDear Editor-in-Chief:Sympathoadrenal activity increases proportionately with the intensity of the exercise and is closely associated with oxygen availability (2,5). In their recent study, Schaal et al. (8) observed reduced plasma norepinephrine (NE) responses to an acute exercise in amenorrheic women when compared to foUicular-phase eumenorrheie women. The authors opine that their findings lend support to the hypothesis that amenorrheic women may experience hypoglycemia-associated autonomie failure-induced suppression of catecholamine (CA) responses to acute exercise. This view deserves further scrutiny especially in the light of the results reported by previous studies.For example, from two extensive studies (2,3) on CA metabolism and exercise-related menstrual irregularities (ERMI), we learn that:1. Acute exercise responses of both NE and epinephrine (EPI) are cycle-and menstrual status-dependent. 2. Menstrual cycle-dependent differences in resting plasma CA disappear with increased training and loss of cycle regularity, while baseline levels of NE significantly increase. 3. Exhaustive training and loss of cycle regularity increase (rather than decrease) plasma NE (and, to some, extent dopamine) at V02max but do not affect EPI responses.Those findings are consistent with the hypothesis that periodic marked elevations in NE levels during maximal exercise may interfere with pulsatile luteinizing hormone release (1) and thus lead to ERMI, although they raise questions about hypoglycemia-associated autonomie failure as a suitable explanation for ERMI. We also note that, in the study by Schaal et al. (8), neither the amenorrheic subjects' HR nor arterial blood pressure at maximal exercise was lower despite their apparent reduced plasma CA responses.In an estrogen-poor environment such as the follicular phase, catechol-0-methyltransferase activity is approximately 20% reduced, whereas it tends to acutely increase with acidosis and in response to chronic exercise (4). ERMI (irrespective of energy balance issues) or loss of fat mass will cause a shift in estrogen metabolism from loa-to C-2 hydroxylase oxidation (3). C-2-substituted estrogens, with their hybrid estrogen/CA structure, exhibit a higher affinity for catechol-0-methyltransferase than CA (3,4) does, the net result potentially being an important decrease in the metabolic clearance rate of CA, which, too, is hard to reconcile with the conclusions by Schaal et al.Brain cortisol may play a role in eating disorders because it interacts with tryptophan and serotonin metabolism. However, the ERMI cortisol data by Schaal et al. show no significant differences. Cortisol levels in ERMI often may represent mere artifacts that would be neutralized by simple correction for caffeine intake or plasma volume (6). Reduced CA responses, hypothetically speaking, could be the result of a simultaneous decrease in CA blood production rate and a much higher increase in metabolic clearance rate. Su...

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Acute effects of exercise on plasma catecholamines in sedentary and athletic women with normal and abnormal menses

Cited by 14 publications

References 14 publications

Physical Activity and Control of the Hypothalamic-Pituitary-Gonadal Axis

Physical Activity and Control of the Hypothalamic-Pituitary-Gonadal Axis

Dysfunctional Uterine Bleeding

Catecholamine Responses to Acute and Chronic Exercise According to Menstrual Status

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