Acute effect of weight loss on levels of total bilirubin in obese, cardiovascular high-risk patients: an analysis from the lead-in period of the Sibutramine Cardiovascular Outcome trial

Andersson, Charlotte; Weeke, Peter; Fosbøl, Emil Loldrup; Brendorp, Bente; Køber, Lars; Coutinho, Walmir; Sharma, Arya M.; Gaal, Luc Van; Finer, Nick; James, W. P. T.; Caterson, Ian D.; Rode, Richard A.; Torp‐Pedersen, Christian

doi:10.1016/j.metabol.2009.04.003

Cited by 74 publications

(59 citation statements)

References 23 publications

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“…The impact of lipid metabolism and a generally lower lipid profile in Gilbert syndrome subjects might also be related to the lower BMI, what was recently shown by our group (16,41). Another observation showed that weight loss was associated with increasing bilirubin levels and was more likely in men (42). Obesity leads to increased oxidative stress (43), as adipose tissue is one major source of elevated plasma oxidants (44) and might also be linked to higher insulin resistance in this group (45).…”

Section: Discussionsupporting

confidence: 56%

Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models

Wallner

Antl

Rittmannsberger

et al. 2013

Cancer Prevention Research

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The bile pigment bilirubin is a known antioxidant and is associated with protection from cancer and cardiovascular disease (CVD) when present in too strong concentrations. Unconjugated bilirubin (UCB) might also possess anti-genotoxic potential by preventing oxidative damage to DNA. Moderately elevated bilirubin levels are found in individuals with Gilbert syndrome and more severe in the hyperbilirubinemic Gunn rat model. This study was therefore aimed to assess the levels of oxidative damage to DNA in Gilbert syndrome subjects and Gunn rats compared to matched controls. Seventy-six individuals (age-and sex-matched) were allocated into Gilbert syndrome (UCB !17.1 mmol/L; n ¼ 38) or control groups (UCB < 17.1 mmol/L; n ¼ 38). In addition, 40 Gunn rats were used to support the results of the human trial. Single-cell gel electrophoresis (SCGE) assay measuring standard conditions (strand breaks, apurinic/apyrimidinic sites) and formamidopyrimidine glycosylase (FPG)-sensitive sites was conducted in human peripheral blood mononuclear cells (PBMC) and rat PBMCs, colon, and hepatocytes. Furthermore, urinary 8-oxo-2 0 -deoxyguanosine (8oxodGuo, DNA oxidation) and 8-oxoguanosine (8oxoGuo, RNA oxidation) were measured in humans. The Gilbert syndrome and Gunn rat groups had significantly higher UCB levels (P < 0.001) than the corresponding controls. No further differences in damage to DNA or RNA were detected between the two groups, except higher strand breaks (PBMCs) in Gunn rats when compared with controls. However, when demographic effects were analyzed, lower 8oxodGuo concentrations were detected in the human group with a BMI !25 kg/m 2 (1.70 AE 0.67 vs. 1.38 AE 0.43 nmol/mmol creatinine, P < 0.05), although this group showed lower UCB levels than normal weight subjects. This study suggests that the disease preventative effect of UCB is unrelated to DNA oxidation/strand breaks in human and animal models of hyperbilirubinaemia. Cancer Prev Res; 6(10); 1056-63. Ó2013 AACR.

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Section: Discussionsupporting

confidence: 56%

Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models

Wallner

Antl

Rittmannsberger

et al. 2013

Cancer Prevention Research

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“…There was also a relationship between occurrence of the metabolic syndrome and a lower concentration of bilirubin [21]. Similar observations were made in obese persons in whom bilirubin concentration was lower than in the group of individuals with normal BMI [22].…”

supporting

confidence: 69%

Parameters of liver function in patients with psoriasis vulgaris

Oszukowska¹,

Kręgiel²,

Kaczmarek³

et al. 2017

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Introduction. Patients with psoriasis develop nonalcoholic fatty liver disease more often than healthy subjects. Objective. To estimate the level of basic parameters of liver function, compare these values between groups of patients with psoriasis and healthy individuals, and refer these values to selected risk factors of developing atherosclerosis. Material and methods. A case-control study in the dermatology department included 66 patients with psoriasis and 30 healthy volunteers. The two groups were comparable as regards age, sex and body mass index as well as abdominal circumference. In all subjects we estimated the parameters of liver function and selected the risk factors of atherosclerosis. Results. γ-Glutamyltransferase activity in patients with psoriasis was significantly higher than in the reference group individuals (p = 0.002) and it applies to men only (p = 0.0003). In women γ-glutamyltransferase activity was higher in patients with positive family history of psoriasis (p = 0.03). γ-Glutamyltransferase activity was also higher in smoking patients (p = 0.02). Activity and concentration of other liver function markers (alanine aminotransferase, aspartate aminotransferase, and bilirubin) did not differ significantly between healthy individuals and patients with psoriasis. There were no differences between patients with severe, moderate and mild psoriasis. A negative correlation between bilirubin concentration and age of patients (p = 0.02) and bilirubin and C-reactive protein concentration (p = 0.03) was observed. Activity of alanine aminotransferase correlated positively with abdominal circumference (p = 0.001), uric acid concentration (p = 0.004) and body mass index (p = 0.001). Activity of aspartate aminotransferase correlated positively with abdominal circumference (p = 0.001), uric acid concentration (p = 0.03) and body mass index (p = 0.001). Additionally, the increase in alanine aminotransferase activity was proportional to the increase in cholesterol (p = 0.01) and apolipoprotein B concentrations (p = 0.03). γ-Glutamyltransferase activity correlated positively with the concentration of uric acid (p = 0.008), cholesterol (p = 0.04), triglycerides (p = 0.04), and apolipoprotein B (p = 0.03). Conclusions. In patients with psoriasis increased activity of alanine aminotransferase and aspartate aminotransferase parameters probably result from liver diseases since they accompany dyslipidemia and obesity whereas the increase of γ-glutamyltransferase activity is probably associated mainly with psoriasis.

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“…As a result, smoking cessation should result in increased serum bilirubin concentrations. As mentioned previously, there is some indication that weight loss is associated with increases in serum bilirubin concentrations (31 ). Likewise, altitude is known to increase serum bilirubin concentrations (79 ).…”

Section: Pharmacologic Nonpharmacologic and Genetic Interventionsmentioning

confidence: 85%

“…Moreover, since weight reduction is known to reduce several cardiovascular risk factors, it is interesting to note that each percent decrease in weight loss was associated with a linear increase in serum bilirubin concentration (31 ).…”

Section: Bilirubin and Body Mass Indexmentioning

confidence: 99%

Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease

2010

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BACKGROUND: Serum bilirubin has been consistently shown to be inversely related to cardiovascular disease (CVD). Recent studies showed serum bilirubin to be associated with CVD-related factors such as diabetes, metabolic syndrome, and body mass index. Although the association of serum bilirubin with CVD has been found in both retrospective and prospective studies, less information is available on the role of genes that control bilirubin concentrations and their association with CVD.CONTENT: In this review, we provide detailed information on the identity of the major genes that control bilirubin concentrations and their association with serum bilirubin concentrations and CVD risk. We also update the results of the major studies that have been performed on the association between serum bilirubin, CVD, and CVD-related diseases such as diabetes or metabolic syndrome. Studies consistently indicate that bilirubin concentrations are inversely associated with different types of CVD and CVD-related diseases. A conditional linkage study indicates that UGT1A1 is the major gene controlling serum bilirubin concentrations, and this finding has been confirmed in recent genomewide association studies. Studies also indicate that individuals homozygous for UGT1A1*28 have a significantly lower risk of developing CVD than carriers of the wildtype alleles.

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Acute effect of weight loss on levels of total bilirubin in obese, cardiovascular high-risk patients: an analysis from the lead-in period of the Sibutramine Cardiovascular Outcome trial

Cited by 74 publications

References 23 publications

Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models

Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models

Parameters of liver function in patients with psoriasis vulgaris

Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease

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