Acute Central Serous Chorioretinopathy and Fundus Autofluorescence

Abstract

In this group of patients, the acute focal RPE leaks seen with FA corresponded precisely to an area of hypo-autofluorescence imaged with FAF. This observation supports the concept that a mechanical defect or absence of the RPE accounts for the leakage from the inner choroid to the sub-neurosensory space in CSC. FAF is also a useful noninvasive diagnostic adjunct to identify the focal RPE leak in patients with acute CSC.

Half-dose vs one-third-dose photodynamic therapy for chronic central serous chorioretinopathy

“…In eyes with CSC, SRF accumulates when the exudation of serous fluid from choroidal vessels exceeds the barrier and the pump functions of RPE. 27 Because retinal atrophy occurs in chronic stage of CSC, 28 the barrier and the pump functions of RPE may be weaker and SRF may accumulate with less exudation in chronic CSC compared with acute CSC. Stronger suppression of the exudation from the choroid may be necessary for the resolution of SRF in chronic CSC than in acute CSC.…”

Photodynamic therapy for central serous chorioretinopathy

“…4,5 These areas are postulated to be caused by choroidal vascular hyperpermeability. 4,[6][7][8] Over the last two decades, numerous treatments for chronic CSCR have been investigated. These have included pharmacologic therapy, laser photocoagulation, photodynamic therapy (PDT) and most recently anti-vascular endothelial growth factor (anti-VEGF).…”

Akut ve Kronik Santral Seröz Koryoretinopatide Fundus Otofloresansı

“…Eandi ve ark. 28 bunun tam tersi olarak 9 akut SSKR'li gözün dokuzunda da sızıntı noktalarının hipootofloresans olduğunu göstermişlerdir. Hipootofloresansın RPE'deki kırılmadan kaynaklandığını öne sürmüşlerdir.…”

“…24 Akut SSKR'li hastalarda seröz retina dekolmanı alanının FOF görüntülemede ödemin otofloresansı bloke etmesi nedeniyle hipootofloresans göründüğü bildirilmiştir. [28][29][30] Framme ve ark. 29 çalışmalarında kronik SSKR'li gözlerdeyse nörosensöryel dekolmanın hiperotofloresans görüldüğünün, bu durumada RPE defektleri ve dekolmana ikincil reaktif RPE değişikliklerinin neden olduğunu bildirmişlerdir.…”