Acute bullous dermatosis and onycholysis due to high-dose methotrexate and leucovorin calcium

Chang, Jae C.

doi:10.1001/archderm.123.8.990b

Cited by 6 publications

(1 citation statement)

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“…Extensive onycholysis was reported following high-dose methotrexate and leucovorin administration. 73 Most of the fingernails and toenails became loose, and some eventually were shed. Low-dose intramuscular injection of methotrexate for psoriasis produced a yellow pigmentation to the fingernails.…”

Section: Ixabepilonementioning

confidence: 99%

Nail Toxicity Induced by Cancer Chemotherapy

Gilbar

Hain

Peereboom

2009

J Oncol Pharm Pract

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Nail toxicity is a relatively uncommon adverse effect linked to a number of chemotherapeutic agents. Clinical presentation varies, depending on which nail structure is affected and the severity of the insult. Nail changes may involve all or some nails. Toxicity may be asymptomatic and limited to cosmetic concerns, however, more severe effects, involving pain and discomfort can occur. Taxanes and anthracyclines are the antineoplastic drug groups most commonly implicated. It is suggested that the administration schedule may influence the incidence of nail abnormalities, for example reported cases linked to the weekly administration of paclitaxel.Before instituting chemotherapy, patients should be educated regarding potential nail toxicities and strategies for prevention implemented. Management includes appropriate nail cutting, avoiding potential irritants, topical, or oral antimicrobials, and possibly cessation or dose reduction of the offending agent. Cryotherapy, through the application of frozen gloves or socks, has been beneficial in reducing docetaxel-induced nail toxicity and may be effective for other drugs.

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Section: Ixabepilonementioning

confidence: 99%