“…Moreover, receptors such as chemokine receptor-5 (CCR5), macrophage inflammatory protein-1α and protein-1β (CCL3 and CCL4, respectively), CCL5, and macrophage chemoattractant protein-2/CCL8 are strongly expressed in affected synovial tissues [ 74 ]. ACL tear-induced changes in synovial cells result in increased enzyme and protein production, affecting synovial fluid composition [ 75 ]. Such changes include imbalances in cell counts, protein content, and levels of inflammatory factors.…”