Acute bacterial meningitis in infants and children

Kim, Kwang Sik

doi:10.1016/s1473-3099(09)70306-8

Cited by 354 publications

(359 citation statements)

References 128 publications

Supporting

Mentioning

338

Contrasting

Unclassified

Order By: Relevance

“…Microbial interactions with the BBB may involve crossing of BMEC in a vacuole (transcytosis), through the intercellular junctional spaces ( paracytosis), or while inside a host cell (e.g., infected phagocyte) using it as a vehicle to cross the barrier (Trojan horse) (Kim 2008(Kim , 2010 (Fig. 2).…”

Section: Pathogen Invasion Of the Bbbmentioning

confidence: 99%

Concepts and Mechanisms: Crossing Host Barriers

Doran

Banerjee

Disson

et al. 2013

Cold Spring Harbor Perspectives in Medicine

111

View full text Add to dashboard Cite

Section: Pathogen Invasion Of the Bbbmentioning

confidence: 99%

Concepts and Mechanisms: Crossing Host Barriers

Doran

Banerjee

Disson

et al. 2013

Cold Spring Harbor Perspectives in Medicine

111

View full text Add to dashboard Cite

“…Despite recent advances in antibiotic therapy and supportive care, bacterial sepsis and meningitis due to E. coli remain a serious disease with unacceptable rates of mortality and morbidity (3). The disease is fatal in 5-40% of infected neonates and causes neurologic sequelae in up to 30% of the survivors (4).…”

Section: B Acterial Meningitis Is the Most Common And Devastating Infmentioning

confidence: 99%

“…A comprehensive understanding of the mechanisms involved at every step of the pathogenesis is vital to develop new methods of treatment and prevention. High degree of bacteremia is a prerequisite for the bacteria to cross the blood-brain barrier, indicating that the bacterium must evade host defense mechanisms and survive in blood or tissues (3). However, precise mechanisms by which E. coli K1 survives in host tissues despite the presence of potent immune cells like dendritic cells (DCs), neutrophils, macrophages, and T cells are still far from clear.…”

Section: B Acterial Meningitis Is the Most Common And Devastating Infmentioning

confidence: 99%

Escherichia coli K1 Promotes the Ligation of CD47 with Thrombospondin-1 To Prevent the Maturation of Dendritic Cells in the Pathogenesis of Neonatal Meningitis

Mittal

González-Gómez

Prasadarao

2010

The Journal of Immunology

View full text Add to dashboard Cite

Dendritic cells (DCs) are professional APCs providing a critical link between adaptive and innate immune responses. Our previous studies have shown that Escherichia coli K1 internalization of myeloid DCs suppressed the maturation of the cells for which outer membrane protein A (OmpA) expression is essential. In this study, we demonstrate that infection of DCs with OmpA+ E. coli significantly upregulates the expression of CD47, an integrin-associated protein, and its natural ligand thrombospondin 1 (TSP-1). Pretreatment of DCs with anti-CD47 blocking Ab or knocking down the expression of CD47 or TSP-1, but not signal regulatory protein α by small interfering RNA, abrogated the suppressive effect of E. coli K1. Ligation of CD47 with a mAb prevented the maturation and cytokine production by DCs upon stimulation with LPS similar to the inhibitory effect induced by OmpA+ E. coli. In agreement with the in vitro studies, suppression of CD47 or TSP-1 expression in newborn mice by a novel in vivo small interfering RNA technique protected the animals against E. coli K1 meningitis. Reconstitution of CD47 knockdown mice with CD47+ DCs renders the animals susceptible to meningitis by E. coli K1, substantiating the role of CD47 expression in DCs for the occurrence of meningitis. Our results demonstrate a role for CD47 for the first time in bacterial pathogenesis and may be a novel target for designing preventive approaches for E. coli K1 meningitis.

show abstract

“…Studies report mortality rates of 26% (Mathew et al 2006). The rapid detection of suspected meningitis is critical for determining an appropriate treatment, but confirming the diagnosis of leptospiral meningitis is often difficult, particularly in developing countries, where there are numerous causes of meningitis (Schlech 1992, Mourvillier & Wolff 2006, Arnoni et al 2007, Lammie et al 2009, Khatami & Pollard 2010, Kim 2010, Lin & Safdieh 2010, Marí et al 2010). An initial presumptive diagnosis is normally made on the basis of clinical observations and then culture of leptospires and MAT are used to confirm the diagnosis (Faine et al 1999).…”

Section: Discussionmentioning

confidence: 99%