Acute arsenic ingestion

Levin-Scherz, Jeffrey; Patrick, John D.; Weber, Frederick; Garabédian, Charles

doi:10.1016/s0196-0644(87)80076-8

Cited by 32 publications

(23 citation statements)

References 7 publications

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“…In our opinion ARDS has rarely been mentioned as the cause of early acute respiratory failure in acute arsenic poisoning because the pulmonary edema responsible for this form of respiratory failure was primarily due to car diac failure [8]. The clinical course ( fig.…”

Section: Discussionmentioning

confidence: 95%

“…The onset of this form of res piratory failure takes some time and usually occurs 4-5 weeks after acute arsenic ingestion as described by Green berg et al [10], Levin-Scherz et al [8] described a fatal case of arsenic poisoning in whom pulmonary edema due to cardiac failure (PAWP 28 mm Hg) developed on the 3rd day after ingestion of 2 g of arsenic trioxide. Death ensued as a result of ventricular fibrillation.…”

Section: Discussionmentioning

confidence: 98%

“…The clin ical features of chronic and acute poisoning have been well described [5][6][7]. Early respiratory failure after acute high-dose ingestion of arsenic is very rare and has seldom been documented [8,9].We report 2 cases of homicidal arsenic poisoning lead ing to early multiple organ failure with adult respiratory distress syndrome (ARDS), intrauterine fetal death and protracted polyneuropathy. The case reports are dis cussed with emphasis on the period of respiratory failure.…”

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confidence: 99%

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Multiple Organ Failure with the Adult Respiratory Distress Syndrome in Homicidal Arsenic Poisoning

Bolliger¹,

Zijl²,

Louw³

1992

Respiration

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A 30-year-old man and a 39-year-old women, who was 28 weeks pregnant, were simultaneously poisoned by eating chocolate containing arsenic trioxide. They developed a picture of multiple organ failure peaking around the 8th to 10th day after ingestion, with the development of life-threatening adult respiratory distress syndrome (ARDS) in both patients. This rarely reported complication of arsenic poisoning was managed successfully by intubation and mechanical ventilation with positive end expiratory pressure in both patients. Hemodynamic and laboratory data are presented supporting the clinical course. Arsenic toxicity further resulted in intrauterine fetal death. The effects of severe arsenic poisoning leading to early multiple organ failure with ARDS as well as to protracted, debilitating polyneuropathy are discussed.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

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Multiple Organ Failure with the Adult Respiratory Distress Syndrome in Homicidal Arsenic Poisoning

Bolliger¹,

Zijl²,

Louw³

1992

Respiration

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“…Severe respiratory effects, including respiratory distress, hemorrhagic bronchitis, and pulmonary edema, were reported in some cases of acute oral As poisoning at doses of 0.08 mg As kg À1 and above (Fincher and Koerker 1987;Levin-Scherz et al 1987;Moore, Ficklin, and Johns 1988;Civantos et al 1995). These effects may be secondary to injury to the pulmonary vasculature.…”

Section: Discussionmentioning

confidence: 99%

Assessing environmental exposure and health impacts of gold mining in Ghana

Armah

Luginaah

Obiri

2012

Toxicological & Environmental Chemistry

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Understanding the extent to which people are being exposed to environmental contaminants helps to identify those populations which may be disproportionately exposed to the contaminants of potential public health concern. This study represents the first report of a comparison of heavy metal arsenic (As), mercury (Hg), cadmium (Cd), cobalt (Co), copper (Cu), lead (Pb), platinum (Pt), zinc (Zn), and manganese (Mn) concentrations in the blood of residents of mining and non-mining communities in Ghana. Blood sampling, health records, and interviews were used in this study to establish the links between the levels of contaminants and health effects in humans within a mining and non-mining community in Ghana. Results of this study show that mean concentration of As in blood in Tarkwa Nsuaem Municipality/Prestea-Huni Valley District (TNMA/PHVD) (mining communities) and Cape Coast Metropolis (CCMA) (non-mining community) was 18-and 2-fold higher, respectively, than the WHO guideline value of 0.002 mg L À1 . The mean concentrations of As, Cd, Pb, Hg, and Mn were elevated up to 20-fold higher in the blood of resident adults and children in TNMA/PHVD than in CCMA. The risk of acute respiratory infections in the exposed populations of TNMA and PHVD were approximately 41-and 12-fold greater than the unexposed group. The risk of diabetes mellitus in the exposed populations of TNMA and PHVD were also approximately 20-and 4-fold higher than the unexposed group. In TNMA and PHVD, 40 blood donors were suffering from hyperkeratosis or pigmentation unlike their CCMA counterparts. Data suggest a potential association between mining activities and the levels of these heavy metals. However, the proportion of anthropogenic contribution to the levels of these metals in the blood remains uncertain. This uncertainty seems to be the umbrella under which both government and mining companies continue to hide, leading to inaction.

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“…Chromium, lead, cadmium and antimony poss serious health hazards (Carpi 1997;Goyer 1993) due to their long half lives and their biochemical effects (Goyer 1996;Hall 2002;Levin-Scherz et al 1987;Rice 1996). The concern about their presence in the environment is increasing day by day.…”

Section: Introductionmentioning

confidence: 99%

Study of heavy metals in some environmental samples

Ahmad

Rashid

Rehman

2008

Environ Monit Assess

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Fuels like coal and rubber are frequently used for brick burning. However, both coal and rubber contain heavy metals. These heavy metals may elutriate in the wake of fly ash or may adsorb or absorb in the product. The present work deals with the analysis of heavy metals in some samples collected from brick burning industries located in the vicinity of a metropolitan city, Peshawar, Pakistan. Samples from raw clay, product, chimney scale and fossil fuel & rubber were collected and leached with acid mixture. The leachates were concentrated and analyzed by atomic absorption spectrophotometer for the determination of chromium (Cr), lead (Pb), cadmium (Cd) and antimony (Sb). It was observed that heavy metals are present in clay, brick and chimney scale. However, significant amount of these metals was observed in chimney scale. It is inferred that such emanations laden with heavy metals are accompanying the stack gases which are being dumped in to the environment. In order to avoid environmental problems, strict environmental regulations shall be enforced and a constant check on these emanations to the environment must be made to ensure clean air act.

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Acute arsenic ingestion

Cited by 32 publications

References 7 publications

Multiple Organ Failure with the Adult Respiratory Distress Syndrome in Homicidal Arsenic Poisoning

Multiple Organ Failure with the Adult Respiratory Distress Syndrome in Homicidal Arsenic Poisoning

Assessing environmental exposure and health impacts of gold mining in Ghana

Study of heavy metals in some environmental samples

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