Acute and subchronic toxicity and genotoxicity of SE5-OH, an equol-rich product produced by Lactococcus garvieae

Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women

“…A description of the product was recently published together with data on its subchronic toxicity and genotoxicity. 23,24 Intervention…”

Mutagenic and antimutagenic effects of the traditional phytoestrogen-rich herbs, Pueraria mirifica and Pueraria lobata

“…Investigation of the mutagenic and/or antimutagenic potentials of herbal plants used in traditional medicine are generating great interest with the growing evidence of their safe consumption and/or low long-term genotoxic effects (17). A few studies using the Ames test and the micronucleus assay have been conducted on phytoestrogen-rich plants or products such as the equol-rich product (18) and genistein (19), showing that the test materials were safe. Therefore, given the increasing exposure to plant phytoestrogens, in the present study we evaluated the P. mirifica and P. lobata extracts in in vitro and in vivo studies using the Ames test for mutagenic and anti-mutagenic assays and the micronucleus test for genotoxicity assays to evaluate the genetic risk or safety of the two plant materials.…”

S-equol and the fermented soy product SE5-OH containing S-equol similarly decrease ovariectomy-induced increase in rat tail skin temperature in an animal model of hot flushes

“…18 To gain insight into the biological effects of S-equol, a fermented soy germ containing S-equol (SE5-OH) has been developed using the equol-producing lactic acid bacterium, Lactococcus 20-92, isolated from the intestinal bacteria of a healthy equol producer. 19 Previous work in nonYequolproducing postmenopausal women has shown that SE5-OH significantly reduces hot flush frequency and severity 20 and improves mood-related symptoms associated with menopause. 21 In addition, bone loss in postmenopausal women was prevented by the ingestion of SE5-OH.…”

“…22 S-equol is believed to be the primary biologically active component of SE5-OH, but it is not clear from studies using this product whether S-equol alone or other bioactive components of SE5-OH such as isoflavones (daidzein, genistein, and glycitein analog) contribute to the observed clinical effects. 19 No studies have directly examined the effect of S-equol on menopausal symptoms.…”