Acute and Subacute Outcome Predictors in Moderate and Severe Traumatic Brain Injury: A Retrospective Monocentric Study

Gritti, Paolo; Zangari, Rosalia; Carobbio, Alessandra; Zucchi, Alberto; Lorini, Ferdinando Luca; Ferri, Francesco; Agostinis, Cristina; Lanterna, Luigi Andrea; Brembilla, Carlo; Foresti, C.; Barbui, Tiziano; Biroli, Francesco

doi:10.1016/j.wneu.2019.04.190

Cited by 15 publications

(17 citation statements)

References 39 publications

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“…Some studies take into consideration the following patients´ characteristics to predict the survival in-hospital: age, gender, trauma mechanism, GCS at admission, pupillary response, cerebral damage, presence of extracranial injury, hypoxia, hypotension, and CT 15,16,19,22,23,30,31 . Therefore prognosis after a TBI is probably multifactorial.…”

Section: Variablesmentioning

confidence: 99%

Predictors of mortality in neurosurgical patients after traumatic brain injury

Godoi¹,

Junior²,

Figueiredo³

et al. 2022

jbnc

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Introduction: Traumatic brain injury (TBI) is considered a relevant worldwide cause of mortality and morbidity. Objective: To evaluate independent factors at hospital admission and during hospitalization that predicts in-hospital mortality in patients with TBI submitted to neurosurgery. Methods: Retrospective cohort analyzed data of patients that underwent neurosurgery due to the TBI. Evaluated predictor factors were age, gender, Glasgow Coma Scale (GCS) at admission, sequels before and after neurosurgery, trauma mechanism, and neurosurgical procedure. The survival analyses were verified. Positive and negative predictive values were calculated. Results: A total of 312 patients were analyzed, majority male (81.4%) with mild TBI (55.8%), and mean age of 49.6 ± 23.5 years. GCS at admission was an independent predictor of mortality (HR = 0.87; 95% CI: 0.81 to 0.93; p < 0.001). The GCS ≤ 13 was the optimal cut-off value to predict survival with a significant difference between GCS groups (≤13 or >13; p<0.001). Patients with GCS ≤ 13 had a six times greater risk of mortality (HR 6.04; 95 CI 2.39 to 15.3; p<0.001). The positive and negative predictive values were 35.8% and 97%, respectively. Conclusions: The GCS in admission is an important predictor of in-hospital mortality in TBI patients that need a neurosurgical procedure.

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Section: Variablesmentioning

confidence: 99%

Predictors of mortality in neurosurgical patients after traumatic brain injury

Godoi¹,

Junior²,

Figueiredo³

et al. 2022

jbnc

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“…Predicting mortality and the GOS has been the primary role of the various outcome-predictor instruments that have been developed over the years, and the major function for which they have been tested ( 5 , 12 , 13 , 17 - 23 ).…”

Section: Baseline Predictors Of Mortality and Glasgow Outcome Scorementioning

confidence: 99%

“…The GCS tends to over-estimate mortality and severe disability, however, as shown in a recently-published study in which, among 189 patients presenting with a GCS of 3, 50.7% survived, and roughly one in seven ultimately achieved a good outcome; this included one patient who presented with a GCS of 3 and bilaterally fixed and dilated pupils( 18 ). The GCS, with or without pupillary reactivity, also fails to take into consideration the significant role that patient age seems to play in determining outcomes post sTBI ( 5 , 25 - 27 ), as well as other factors like the patient’s other injuries, general health status, current consumption of drugs and/or alcohol, and findings on imaging ( 28 ).…”

Section: Baseline Predictors Of Mortality and Glasgow Outcome Scorementioning

confidence: 99%

“…Severe traumatic brain injury (sTBI) is a common cause of death and disability worldwide ( 1 - 4 ), with 14- and 30-day mortality rates frequently in the 15-30% range ( 2 , 5 - 8 ). On the other hand, up to half of patients experience significant recovery, to the point where they become able to take care of themselves, and perhaps even return to work or school ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Baseline Predictors of Survival, Neurological Recovery, Cognitive Function, Neuropsychiatric Outcomes, and Return to Work in Patients after a Severe Traumatic Brain Injury: an Updated Review

Algethamy¹

2020

Mater Sociomed

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Introduction: Severe traumatic brain injury (sTBI) is a common cause of death and disability worldwide, with long-term squeal among survivors that include cognitive deficits, psychosocial and neuropsychiatric dysfunction, failure to return to pre-injury levels of work, school and inter-personal relationships, and overall reduced quality of and satisfaction with life. Aim: The aim of this work is to review the current literature on baseline predictors of outcomes in adults post sTBI. Method: Most of available literature on baseline predictors of outcomes in adults post sTBI were reviewed and summarized in this work. Results: Currently, a sizeable number of composite predictors of mortality and overall function exists; however, these instruments tend to over-estimate poor outcomes and fail to address issues like cognition, psychosocial/ neuropsychiatric dysfunction, and return to work or school. Conclusion: This article reviews currently-identified predictors of all these outcomes.

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“…Several factors have been repeatedly found to be associated with short- and long-term prognoses of these symptoms after TBI. Some of the most important sociodemographic characteristics include age [ 4 , 5 , 9 , 16 , 20 , 24 , 25 , 29 , 44 , 45 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ], gender/sex [ 4 , 5 , 9 , 16 , 17 , 19 , 20 , 24 , 25 , 29 , 37 , 44 , 81 , 82 , 84 , 85 , 86 ], living situation [ 15 , 24 ], employment status [ 5 , 24 , 80 , 82 ], marital status [ 5 , 16 , 19 , 82 , 86 ], education [ 9 , 11 , 20 , 24 , 28 , 70 , 82 , 84 ], ethnicity/race [ 9 , 16 , 19 , 28 , …”

Section: Introductionmentioning

confidence: 99%

Comparability of (Post-Concussion) Symptoms across Time in Individuals after Traumatic Brain Injury: Results from the CENTER-TBI Study

Rivera

Greving

Arango-Lasprilla

et al. 2022

JCM

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Post-concussion symptoms often occur after TBI, persist and cause disabilities. The Rivermead Post-Concussion Symptoms Questionnaire (RPQ) is widely used in this population, but little is known about the comparability of the symptoms over time, i.e., longitudinal measurement invariance (MI). The objectives of this study were to analyze the longitudinal MI of RPQ symptoms from three to twelve months after TBI and to find factors related to RPQ symptoms. The study involved 1023 individuals after TBI who took part in the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study and completed the RPQ at three, six and twelve months post-injury. Longitudinal confirmatory factor analysis showed that the three-factor structure (somatic, emotional and cognitive) remains stable within one year after TBI. Linear mixed models revealed that sex, injury cause and prior psychiatric problems were related to the RPQ three-factor structure as well as to the RPQ total score. The study strengthens evidence for the RPQ’s factorial structure stability within one year after TBI and identifies sex, injury cause and prior psychiatric problems as important factors that may help clinicians to prevent future complications of symptomatology after TBI.

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Acute and Subacute Outcome Predictors in Moderate and Severe Traumatic Brain Injury: A Retrospective Monocentric Study

Cited by 15 publications

References 39 publications

Predictors of mortality in neurosurgical patients after traumatic brain injury

Predictors of mortality in neurosurgical patients after traumatic brain injury

Baseline Predictors of Survival, Neurological Recovery, Cognitive Function, Neuropsychiatric Outcomes, and Return to Work in Patients after a Severe Traumatic Brain Injury: an Updated Review

Comparability of (Post-Concussion) Symptoms across Time in Individuals after Traumatic Brain Injury: Results from the CENTER-TBI Study

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