2016
DOI: 10.5897/ajb2016.15669
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Acute and sub-chronic toxicity study of the extract and powder of Operculina macrocarpa (L.) Urb. in mice

Abstract: The aim of the study was to evaluate the experimental acute and sub-chronic toxicities of Operculina macrocarpa with plant extract and powder, respectively, in male and female mice. Phytochemical prospection was performed with extract and administration in single doses by intraperitoneal route to six groups and control at 1230, 970, 700, 350, 120 and 30 mg/kg doses and distilled water (0.1 ml/10 g), respectively. Sub-chronic doses of 1230, 700, 30 mg/kg/day and satellite (1230 mg/kg/day) were administered oral… Show more

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